Input on my test results

[Boymama]

Can someone please help me understand my results?  I’ve been trying to get answers for almost ten years and I haven’t heard from my doctor yet.  I’d really like to know if celiac is a possible diagnosis. 
 

TISSUE TRANSGLUTAMINASE
IGA (U/ML)
Your value
<0.5 U/mL
Standard range
<=14.9 U/mL
DEAMIDATED GLIADIN
PEPTIDE IGA, QUALITATIVE,
EIA
Your value
149.3 U/mL
Standard range
<=14.9 U/mL
TISSUE
TRANSGLUTAMINASE+DEAMID.
GLIADIN PEPTIDE AB INTPN

[Russ H]

4 minutes ago, Boymama said:

Can someone please help me understand my results?  I’ve been trying to get answers for almost ten years and I haven’t heard from my doctor yet.  I’d really like to know if celiac is a possible diagnosis. 
 

TISSUE TRANSGLUTAMINASE
IGA (U/ML)
Your value
<0.5 U/mL
Standard range
<=14.9 U/mL
DEAMIDATED GLIADIN
PEPTIDE IGA, QUALITATIVE,
EIA
Your value
149.3 U/mL
Standard range
<=14.9 U/mL
TISSUE
TRANSGLUTAMINASE+DEAMID.
GLIADIN PEPTIDE AB INTPN

Oh yes. Do you have any more information - symptoms, test results (total iGA for example)?

[Boymama]

2 minutes ago, Russ314 said:

Oh yes. Do you have any more information - symptoms, test results (total iGA for example)?

I think this is all my doctor tested for. It’s the first thing to come up abnormal.  I’ve had neurological symptoms with no answers for many years. Doctors have been dismissive.  They just kept checking for ms but all mri scans have been normal. I’ve had chronic constipation and bloating my entire adult life.  I get those itchy blisters on my fingers and bottom of my feet. Also fatigue, loss of balance, numbness and tingling. Lots of strange symptoms over the years. Am I considered iga deficient? 

[trents]

The results you posted did not include a total serum IGA so I assume your doctor did not test you for this, which should have been done. It sounds like you probably know already that low total IGA can result in false negative tTG-IGA scores. The tTG-IGA is considered the best one test to order since it combines good specificity with good sensitivity. Was there any m

On the other hand, your doctor did order a secondary test which can also diagnose celiac disease, the DEAMIDATED GLIADIN PEPTIDE IGA, which was unequivocally positive.  And you have several symptoms which are common to either celiac disease or NCGS (Non Celiac Gluten Sensitivity). And your "itch blisters" sound like they could be dermatitis herpetaformis (DH) which is a lock for celiac disease.

By any chance, were you already trying to eat gluten free when your blood sample was taken? Don't try to go gluten free until all testing is complete. Your doctor may want to arrange for an endoscopy/biopsy.

[Russ H]

Just now, Boymama said:

I think this is all my doctor tested for. It’s the first thing to come up abnormal.  I’ve had neurological symptoms with no answers for many years. Doctors have been dismissive.  They just kept checking for ms but all mri scans have been normal. I’ve had chronic constipation and bloating my entire adult life.  I get those itchy blisters on my fingers and bottom of my feet. Also fatigue, loss of balance, numbness and tingling. Lots of strange symptoms over the years. Am I considered iga deficient? 

You could be IgA deficient, but it needs to be tested for. It is also possible to have coeliac disease and test negative for transglutaminase antibodies without being IgA deficient. It is a complex immunological condition. Certainly, your symptoms could be caused by coeliac disease. I had neurological symptoms and unusual skin complaints prior to diagnosis. All resolved now.

[Boymama]

1 minute ago, trents said:

The results you posted did not include a total serum IGA so I assume your doctor did not test you for this, which should have been done. It sounds like you probably know already that low total IGA can result in false negative tTG-IGA scores. The tTG-IGA is considered the best one test to order since it combines good specificity with good sensitivity. Was there any m

On the other hand, your doctor did order a secondary test which can also diagnose celiac disease, the DEAMIDATED GLIADIN PEPTIDE IGA, which was unequivocally positive.  And you have several symptoms which are common to either celiac disease or NCGS (Non Celiac Gluten Sensitivity). And your "itch blisters" sound like they could be dermatitis herpetaformis (DH) which is a lock for celiac disease.

By any chance, were you already trying to eat gluten free when your blood sample was taken? Don't try to go gluten free until all testing is complete. Your doctor may want to arrange for an endoscopy/biopsy.

Years ago I followed a paleo diet and I definitely felt better but my symptoms didn’t go away completely so I stopped.  But I also wasn’t 100% gluten free.  Lately I have been eating low carb so naturally eating less gluten. I didn’t know he was going to test for celiac.  I started eating gluten these last few days in case a biopsy was the next step.  I definitely don’t feel well, fatigue, brain fog and the itchy rash showed up. 

[Mmkay24]

I could have written this myself! My symptoms are the same and I also tested strong positive for gliadin peptide iga. I haven’t spoken to my doctor yet but I am also curious if this is positive. I also have a strong family history or celiac/auto immune disorders. 

[trents]

Welcome to the forum mMkay24!

You say that your gliadin peptide IGA was strongly positive but then you say, "I am also curious if this is positive." Those two statements seem at odds with one another. What exactly are you asking about as being positive? Can you please post the whole of the test results, along with reference ranges?