Help please!

[Shem]

Thanks for this! Yeah the only deficiency was the vit d and I had quite  thorough blood tests done. 👍

[knitty kitty]

6 hours ago, Shem said:

Thanks for this! Yeah the only deficiency was the vit d and I had quite  thorough blood tests done. 👍

Was your thiamine level tested?  Which test was used to measure it? 

Thiamine deficiency can still occur although blood levels are within "normal" levels because blood tests don't accurately measure the amount of thiamine in the tissues.  The body will starve the tissues in order to maintain thiamine level in the blood so thiamine will get into the brain.  Blood thiamine level will reflect how much Thiamine was consumed in the diet during the previous twenty-four to forty eight hours.  If you were taking a multivitamin at the time of testing, that would skew the results as well.

[Russ H]

5 hours ago, knitty kitty said:

Please provide a source or reference for this statement.

Sources give varying figures. In young children, the half-life is a little less than 2 months:

https://www.tandfonline.com/doi/abs/10.3109/00365513.2015.1124449

 

This study on older children in India indicated a fall of about 50% in IgA anti-tTG2 after about 6 months:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482799/

 

In this study, "by 4 months, 44% of patients had a ≥ 50% reduction in anti-tTG antibodies"

https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2009.04039.x

 

In this medical guidance from Israel "One of the tests used most often, tissue transglutaminase (tTG), has a half-life of
six months."

https://www.bidmc.org/-/media/files/beth-israel-org/centers-and-departments/digestive-disease-center/celiac-center/2faq-diagnosing-celiac-disease-feb-2016.ashx?la=en&hash=14EEDD7CF8431C4B098941F697DCD8F6E97901B2.

 

This small study shows antibodies roughly halving by 6 months (combined IgA and IgG):

https://www.researchgate.net/publication/332361081_Higher_serum_IL-17A_along_with_anti-tTG_antibodies_for_prediction_of_refractory_celiac_disease

 

University of Chicago Celiac Disease Center says 3-4 months:

https://www.cureceliacdisease.org/faq/what-is-the-half-life-of-antibodies-in-the-blood-serum/

 

This review paper suggests IgA-tTG has a half life of 4 weeks:

https://journals.sagepub.com/doi/pdf/10.1258/000456306776021599

 

This study of IgA deficient people showed an IgG anti-tTG half life of a year or more:

https://gut.bmj.com/content/52/11/1567

 

This training handbook suggests an antibody half-life of 3-6 months:

http://www.gastroenterologybook.com/Small-Bowel/Coeliac-Disease/Coeliac-Management

 

 

[knitty kitty]

Thank you.

It's interesting to note levels at diagnosis, severity of intestinal damage, and degree of adherence to gluten-free diet also affect autoantibody production and half life.