Help understanding results

[Joshua98]

Hello, 

I am 23M. I have been suffering all my life of stomach pain, diarrhea, constant headache, migraines, hair loss, and more. I recently got some testing done because I was getting really sick. I recently found this forum while doing some research on my tests results since my gastroenterologist is taking forever to give me news.

Here are some testing I have done: 

• TTG IgA 84.2 U/ml Positive
• HLA DQ2     Positive
• HLA DQ8     Negative
• HLA DQA3   Negative
• HLA DQA5   Positive

Duodenum biopsy: 

Microscopic examination of several biopsy fragments spread over two slides stained with HPS and PAS. On histological examination. these are several fragments of mucous membrane of small intestine, some of which have a well-preserved villous profile and others show partial flattening. We also have some villi which are completely flattened. In areas where there is partial to complete flattening. there is an increase in the chronic inflammatory contingent. There are also a small significant lymphoepithelial infiltrate. but not diffuse. on the fragments studied. It is rather associated with the villi which are partial. There is no associated active inflammation. There is no microorganism with HPS and PAS stains.

- Fragments of small intestine mucosa with villous profile in places partially or completely flattened accompanied by an inflammatory infiltrate chronic (See microscopic description).

- Absence of micro-organism in HPS and PAS stains.

- Absence of neoplasia.

 

Thank you for your time. 

 

 

[trents]

17 minutes ago, Joshua98 said:

Hello, 

I am 23M. I have been suffering all my life of stomach pain, diarrhea, constant headache, migraines, hair loss, and more. I recently got some testing done because I was getting really sick. I recently found this forum while doing some research on my tests results since my gastroenterologist is taking forever to give me news.

Here are some testing I have done: 

• TTG IgA 84.2 U/ml Positive
• HLA DQ2     Positive
• HLA DQ8     Negative
• HLA DQA3   Negative
• HLA DQA5   Positive

Duodenum biopsy: 

Microscopic examination of several biopsy fragments spread over two slides stained with HPS and PAS. On histological examination. these are several fragments of mucous membrane of small intestine, some of which have a well-preserved villous profile and others show partial flattening. We also have some villi which are completely flattened. In areas where there is partial to complete flattening. there is an increase in the chronic inflammatory contingent. There are also a small significant lymphoepithelial infiltrate. but not diffuse. on the fragments studied. It is rather associated with the villi which are partial. There is no associated active inflammation. There is no microorganism with HPS and PAS stains.

- Fragments of small intestine mucosa with villous profile in places partially or completely flattened accompanied by an inflammatory infiltrate chronic (See microscopic description).

- Absence of micro-organism in HPS and PAS stains.

- Absence of neoplasia.

 

Thank you for your time. 

 

 

Welcome to the forum, Joshua98!

What is your question for us?

All three dimensions of celiac diagnosis (genetics, serum antibody tests and biopsy) point to celiac disease. What are you uncertain about?

[Joshua98]

I was wondering if it was for sure celiac. I don't know, I'm just lost and confused. This is big news and I'm stressing about it.

[trents]

There really is no question that you have celiac disease. Everything points to it. Believe me, all of us in the celiac community understand the shock of getting this diagnosis because of the lifestyle changes it demands. It will have a major impact, not only on your eating habits but on your social life. Lots of adjustments are ahead and a significant learning curve as well with regard to truly eliminating gluten from your diet, as opposed to just practicing lower gluten eating. But of course, you could choose, as some do, to just live in denial and continue to trash your body by continuing to consume gluten. That wouldn't be too bad for a while at your young age but with time it could result in osteoporosis, anemia, neurological problems, and many more health issues. 

You are blessed in that you have discovered this at such a young age and caught it before much damage has been done to your body.

[Scott Adams]

Hopefully your doctors have told you to begin a gluten-free diet now, and here is some helpful info for you: