Anti-tissue transglutaminase antibodies not related to gluten intake but Cows Milk Protein IE Casein Instead

[Posterboy]

To All,

I came across this research recently and I thought it was worth sharing as a separate thread topic and I wondered what other's thought of it?

Entitled "Anti-tissue transglutaminase antibodies not related to gluten intake" (from) IE Cows Milk protein

https://pubmed.ncbi.nlm.nih.gov/29555204/

quoting from their abstract

"Symptoms disappeared, and anti-tTG was normal after (Cows Milk Protein) aka CMP  free diet with gluten intake. All the patients had susceptibility haplotype HLA DQ2/DQ8.

CONCLUSIONS:

CMP (again Cows Milk Protein) ingestion after an exclusion diet can induce an increase in anti-tTG in some coeliac subjects. CMP can produce this immune response (even) if there were no gluten transgressions."

I see alot where people are pushed to consider "hidden gluten" in their diet often......when often times it other "Hidden Proteins" in their diet one does not traditionally think can trigger a "Gluten like" reaction in their bodies that they have not yet removed from their diet and why I share here now.

Maybe it will  help someone else.

When we get low in stomach acid we can no longer process food protiens into harmless peptides and amino acids that pose no threat to our small intestines.....but ALL kinds of proteins especially Casein can also trigger a "Gluten Like" reaction in Celiac's.......and it is not as as low as you might think.....several research article say between 40 percent and up to at least 50 percent of Celiac's also react to Casein (or as summarized in this article as Cows Milk Protein) can ALONE by itself trigger a "Gluten Like" reaction even when one is sure they are gluten free.

This thread entitled "Still having problems" despite beign gluten free for 3 years inspired me to post this research

Maybe it will help someone else.

I hope this is helpful but it is not medical advice.

2 Timothy 2:7 "Consider what I say; and the Lord give thee understanding in all things"  including this.

Posterboy by the Grace of God,

[trents]

43 minutes ago, Posterboy said:

To All,

I came across this research recently and I thought it was worth sharing as a separate thread topic and I wondered what other's thought of it?

Entitled "Anti-tissue transglutaminase antibodies not related to gluten intake" (from) IE Cows Milk protein

https://pubmed.ncbi.nlm.nih.gov/29555204/

quoting from their abstract

"Symptoms disappeared, and anti-tTG was normal after (Cows Milk Protein) aka CMP  free diet with gluten intake. All the patients had susceptibility haplotype HLA DQ2/DQ8.

CONCLUSIONS:

CMP (again Cows Milk Protein) ingestion after an exclusion diet can induce an increase in anti-tTG in some coeliac subjects. CMP can produce this immune response (even) if there were no gluten transgressions."

I see alot where people are pushed to consider "hidden gluten" in their diet often......when often times it other "Hidden Proteins" in their diet one does not traditionally think can trigger a "Gluten like" reaction in their bodies that they have not yet removed from their diet and why I share here now.

Maybe it will  help someone else.

When we get low in stomach acid we can no longer process food protiens into harmless peptides and amino acids that pose no threat to our small intestines.....but ALL kinds of proteins especially Casein can also trigger a "Gluten Like" reaction in Celiac's.......and it is not as as low as you might think.....several research article say between 40 percent and up to at least 50 percent of Celiac's also react to Casein (or as summarized in this article as Cows Milk Protein) can ALONE by itself trigger a "Gluten Like" reaction even when one is sure they are gluten free.

This thread entitled "Still having problems" despite beign gluten free for 3 years inspired me to post this research

Maybe it will help someone else.

I hope this is helpful but it is not medical advice.

2 Timothy 2:7 "Consider what I say; and the Lord give thee understanding in all things"  including this.

Posterboy by the Grace of God,

Thanks for the info, Posterboy. We have known for awhile that CMP can blunt villi but this demonstrates what many of us assumed that it also produced some of the same antibodies that gluten does.

[Scott Adams]

This is definitely interesting, and we did a summary on this a while back (below). It probably makes sense for anyone with celiac disease and ongoing symptoms to go dairy-free for a while to see if it helps.

 

[Posterboy]

Trents and Scott,

I just wanted to post this nice feature article about Cows Milk Protien in a Child Celiac's recovery story.

It shows, at least in some Celiac, that Casein's are definitely a trigger for on going issues in Celiac's.

It is well worth the read for any one (child or adult) who is still struggling to recovery from Celiac thinking only gluten is causing their problems.

I was this child (when I was younger) so I know how they felt....

As always, I hope this is helpful but it is not medical advice.

Posterboy by the grace of God,

[trents]

Yes, there has been other recent research cited on the forum lately pointing to the high percentage of celiacs who experience villi inflammation from CMP. One study cited claimed as high as 50% of celiacs experience the same antibodies from casein as they do from gluten. This is something that needs more attention, both from the celiac community and the medical science community. Certainly, it could account for a high percentage of refractory celiac disease.

[Blue-Sky]

On 8/29/2022 at 4:56 PM, Posterboy said:

Entitled "Anti-tissue transglutaminase antibodies not related to gluten intake" (from) IE Cows Milk protein

https://pubmed.ncbi.nlm.nih.gov/29555204/

Here is a link to the full study.

https://www.sciencedirect.com/science/article/pii/S2341287918301601

"We conducted a retrospective observational study by reviewing the cases of all patients managed in the outpatient clinics of our hospital between 2002 and 2010 in whom celiac disease was initially suspected but whose serological patterns were atypical during the followup, that is, in whom changes in the levels of anti-tTG antibodies were not associated with gluten intake."

And further down:

"Of the 629 patients assessed for suspected celiac disease in the 2002–2010 period, 11 (1.7%) exhibited an atypical serologic pattern. We excluded 2 of these patients due to confirmation of an infectious aetiology (Giardia lamblia and Campylobacter jejuni). Intestinal infection was ruled out in the 9 remaining patients (1.4%). The median duration of followup was 10 years (IQR, 8–12.5)."

For the group mentioned above it sounds like this might be a rare thing.

This paper has some information about the recovery rate for Celiac disease and a tolerable upper limit of gluten uptake. If cows milk protein commonly caused the same damage as gluten I think recovery rates would not generally match at all with the amount of trace gluten consumption.  Or it could be wheat cross contamination is common in some foods made with dairy.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2036.2008.03669.x

The conclusion is that:

"Conclusions The amount of tolerable gluten varies among people with coeliac disease. Although there is no evidence to suggest a single definitive threshold, a daily gluten intake of <10 mg is unlikely to cause significant histological abnormalities."