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Celiac VS NCGS


Johariellis

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Johariellis Rookie

Hi guys! What would you say is the MAIN difference between Celiac and non celiac gluten sensitivity symptom wise? Is it the yellow and stinky poos after eating gluten? I’m getting tested on Monday and I don’t know why it makes me so nervous/anxious 🤣 I guess I just don’t wanna feel stupid. 


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trents Grand Master

Welcome to the forum, Johariellis!

Unfortunately, it's not possible to distinguish the two based on symptoms since celiac disease and NCGS share many of the same symptoms. That is a big part of why we encourage the testing for celiac disease. In view of the fact that you will be tested in a few days I trust you did not make the mistake of already starting a gluten free diet.

Johariellis Rookie

Nope! Still on the gluten for now :( Definitely not enjoying it 🤣

Scott Adams Grand Master

These articles are older, but still may be helpful. NCGS is still being mapped out in studies:

 

 

 

 

 

Wheatwacked Veteran

Choline is the most abundant salt in BILE and helps keep bile healthy. This powerful nutrient has been shown to improve many health conditions, including, ALL neuro-degenerative conditions, liver conditions, cognitive performance, fetal development, even glaucoma.  https://www.panaceanutritionals.com/blog/2018/10/27/choline-the-most-important-nutrient-of-the-body#:~:text=Choline is a fat emulsifier,critical processes of the body.

Choline is a fat emulsifier and reduces the surface tension in fat and bile. Choline is one of the salts you will see in healthy bile which allows the body to breakdown fat into fatty acids for the building of the brain, supplying cell membranes, and dozens of critical processes of the body. 

 limit bile reaching your intestines, which can turn your stool yellow. https://www.healthline.com/health/yellow-stool-ibs#yellow-stool

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    • trents
      NCGS does not cause damage to the small bowel villi so, if indeed you were not skimping on gluten when you had the antibody blood testing done, it is likely you have celiac disease.
    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
    • Xravith
      I'm very confused... My blood test came out negative, I checked all antibodies. I suppose my Total IgA levels are normal (132 mg/dl), so the test should be reliable. Still, I'm not relieved as I can't tolerate even a single biscuit. I need to talk to my doctor about whether a duodenal biopsy is necessary. But it is really possible to have intestinal damage despite having a seronegative results? I have really strong symptoms, and I don't want to keep skipping university lectures or being bedridden at home.
    • Scott Adams
      They may want to also eliminate other possible causes for your symptoms/issues and are doing additional tests.  Here is info about blood tests for celiac disease--if positive an endoscopy where biopsies of your intestinal villi are taken to confirm is the typical follow up.    
    • Scott Adams
      In the Europe the new protocol for making a celiac disease diagnosis in children is if their tTg-IgA (tissue transglutaminase IgA) levels are 10 times or above the positive level for celiac disease--and you are above that level. According to the latest research, if the blood test results are at certain high levels that range between 5-10 times the reference range for a positive celiac disease diagnosis, it may not be necessary to confirm the results using an endoscopy/biopsy: Blood Test Alone Can Diagnose Celiac Disease in Most Children and Adults TGA-IgA at or Above Five Times Normal Limit in Kids Indicates Celiac Disease in Nearly All Cases No More Biopsies to Diagnose Celiac Disease in Children! May I ask why you've had so many past tTg-IgA tests done, and many of them seem to have been done 3 times during short time intervals?    
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