Anhidrosis (inability or slow to sweat)

[Dtoc]

just checking if anyone has a difficult time sweating and/or if this is related somehow to either celiac/gluten sensitivity or possibly adrenal fatigue?

I thought that my being cold 24/7 was due to thyroid, but that was not the case. And then I recently read that feeling cold was a symptom of low adrenal function.

I've never been much of a 'sweater', even 20 minutes in a sauna does not produce much. Is there anything that fixes this issue? TY!!

[trents]

Welcome to the forum, Dtoc!

I have not heard of anhidrosis being related to gluten-related diseases. Have you experienced this for many years or is this a recent problem? How long have you known you have a gluten-related disorder?

[Dtoc]

26 minutes ago, trents said:

Welcome to the forum, Dtoc!

I have not heard of anhidrosis being related to gluten-related diseases. Have you experienced this for many years or is this a recent problem? How long have you known you have a gluten-related disorder?

quite recently actually, I'm only 7 weeks gluten-free, genetic testing revealed HLA DQ 2, 1, 3, and I've always had difficulty sweating so I wasn't sure if it was related. I'm curious to see that as time goes on gluten-free, things will change. 

It's annoying, I call it 'sweat constipation'

 

[trents]

Have you researched anhidrosis and what can cause it?

[Dtoc]

21 minutes ago, trents said:

Have you researched anhidrosis and what can cause it?

yes, interestingly, it can be related to autoimmune, Sjogrens and Scleroderma

https://www.medicalnewstoday.com/articles/266427#causes

weird, my mom had celiac but my younger brother had severe scleroderma, maybe there's a link.

[knitty kitty]

B12 deficiency can cause anhidrosis (not sweating) and hypohidrosis (very little sweating). 

B12 deficiency is common in both Celiac Disease and scleroderma as well as Sjogren's syndrome.

Celiac Disease can cause problems with absorption of Vitamin B12 Cobalamine.  B12 needs to bind with an intrinsic factor produced in the stomach in order to be absorbed.  The production of the intrinsic factor can be affected by low stomach acid, or use of PPI's and other pharmaceuticals.  Absorption of B12 with the intrinsic factor can be affected by the extent of damage done to the small intestine by the Celiac Disease autoimmune response.  

One can have deficiency symptoms in B12 before blood tests register a deficiency.  

Deficiencies in vitamins that work with B12, like folate, pyridoxine and thiamine, can also reduce B12 functioning.  

Hope this helps!

[ravenwoodglass]

8 hours ago, knitty kitty said:

B12 deficiency can cause anhidrosis (not sweating) and hypohidrosis (very little sweating). 

B12 deficiency is common in both Celiac Disease and scleroderma as well as Sjogren's syndrome.

Celiac Disease can cause problems with absorption of Vitamin B12 Cobalamine.  B12 needs to bind with an intrinsic factor produced in the stomach in order to be absorbed.  The production of the intrinsic factor can be affected by low stomach acid, or use of PPI's and other pharmaceuticals.  Absorption of B12 with the intrinsic factor can be affected by the extent of damage done to the small intestine by the Celiac Disease autoimmune response.  

One can have deficiency symptoms in B12 before blood tests register a deficiency.  

Deficiencies in vitamins that work with B12, like folate, pyridoxine and thiamine, can also reduce B12 functioning.  

Hope this helps!

Sublingual B12 is helpful until we have healed as it is absorbed by the mucous membranes and can enter the system that way.

[Dtoc]

11 hours ago, knitty kitty said:

B12 deficiency can cause anhidrosis (not sweating) and hypohidrosis (very little sweating). 

B12 deficiency is common in both Celiac Disease and scleroderma as well as Sjogren's syndrome.

Celiac Disease can cause problems with absorption of Vitamin B12 Cobalamine.  B12 needs to bind with an intrinsic factor produced in the stomach in order to be absorbed.  The production of the intrinsic factor can be affected by low stomach acid, or use of PPI's and other pharmaceuticals.  Absorption of B12 with the intrinsic factor can be affected by the extent of damage done to the small intestine by the Celiac Disease autoimmune response.  

One can have deficiency symptoms in B12 before blood tests register a deficiency.  

Deficiencies in vitamins that work with B12, like folate, pyridoxine and thiamine, can also reduce B12 functioning.  

Hope this helps!

Thank you both!! B12 is in my B complex so I only added the sublingual at most, once a day. I will try increasing the dosage moving forward. The sjogrens connection is interesting as when I finally 'crashed' (so to speak) over the past year my mouth was incredibly dry/burning, strange, even my teeth were dry if that makes any sense. And I remembered when I was a teenager, I had a stone blocking my salivary gland. It would swell up bigger than a golf ball and I had to have it removed. UGH I wish they had investigated the cause further. Better late than never I guess!! Thanks again, much appreciated!!!

[Kathryn W]

Your initial question is if others with Celiac have difficulty sweating. I do. I don’t sweat until I’m beat red. When exercising, others become concerned because rather than sweat, I turn red all over. It takes a long time before I’ll sweat. I have celiac and have never really sweated, even in my growing up years. 

This is fascinating… I wish more would share their experiences. 

[Kathryn W]

17 hours ago, knitty kitty said:

B12 deficiency can cause anhidrosis (not sweating) and hypohidrosis (very little sweating). 

B12 deficiency is common in both Celiac Disease and scleroderma as well as Sjogren's syndrome.

Celiac Disease can cause problems with absorption of Vitamin B12 Cobalamine.  B12 needs to bind with an intrinsic factor produced in the stomach in order to be absorbed.  The production of the intrinsic factor can be affected by low stomach acid, or use of PPI's and other pharmaceuticals.  Absorption of B12 with the intrinsic factor can be affected by the extent of damage done to the small intestine by the Celiac Disease autoimmune response.  

One can have deficiency symptoms in B12 before blood tests register a deficiency.  

Deficiencies in vitamins that work with B12, like folate, pyridoxine and thiamine, can also reduce B12 functioning.  

Hope this helps!

Fascinating. My doc continues to be concerned with my Vitamin B levels. She is always reminding me to take Vitamin B and I even went through 3 phases of Vitamin B prescriptions. My levels are always low.  I will share this information with her the next time I see her. I did not get diagnosed with Celiac until I was in my 50’s.n Maybe there is just on much damage there. 

[Dtoc]

49 minutes ago, Kathryn W said:

Your initial question is if others with Celiac have difficulty sweating. I do. I don’t sweat until I’m beat red. When exercising, others become concerned because rather than sweat, I turn red all over. It takes a long time before I’ll sweat. I have celiac and have never really sweated, even in my growing up years. 

This is fascinating… I wish more would share their experiences. 

The redness, absolutely!! Tennis, running, saunas, steam rooms, to no avail. And it's always been that way, even deodorant was never a necessity of sorts either.

My very unscientific theory to this is, could the 'consistency' of all that gluten, throughout a lifetime, basically gum up the sweat glands? And does the lymphatic system take the brunt of the damage instead? So many questions!!!

[GlutenMorgen]

I got anhidrosis and temperature dysregulation as well!

Most ppl with Celiac are also deficient in thiamin (B1), since gluten-free options are frequently devoid of this vitamin or its natural form. I suspect I have thiamin deficiency, long term, I don't tolerate it well at all, unless I titrate it up slowly... It's majorly involved in energy metabolism, nervous system and acetylcholine production, which, along with B3, B4, B5, and iodine activate those sweat glands!

The right way to test B1 deficiency is to test transketolase. Technically, if there's been a long term insufficiency, the enzymes are going to be downregulated, but blood may show sufficient thiamin.

Unfortunately, here in my country they don't test for that, but I believe in the U.S. they do.

 

[Following this topic. Me here, with severe gluten sensitivity (bleeding, connective tissue damage, histamine and adrenaline attacks).]

[Wheatwacked]

Welcome to the forum GlutenMorgan.

 

3 hours ago, GlutenMorgen said:

acetylcholine production

If you are following a "healthy" diet using the guidelines developed over the past 50 years that liver, red meat and eggs are bad you will most likely, along with 90% of the people following that advice, are not getting enough choline in your diet.  It takes 10 cups daily of cooked brocolli or similar vegetable to get the US RDA, compared to 4 eggs a day.   In the second stage, the acetyl CoA reacts with choline to form acetylcholine. The enzyme choline acetyltransferase catalyzes this stage.  PhosphatidylCholine forms about 80% of the mitochondrial membrane.

 

High B12 indicates thiamine deficiency  Thiamine Deficiency Testing: Understanding the Labs

Benfotiamine was originally discovered over 50 years ago in roasted crushed garlic and onions. It is a precursor to thiamine (vitamin B1), in which the ring substructure remains open. This means that it is fat soluble and can cross cellular membranes more freely than thiamine's closed-ring structure. Once inside the cell, benfotiamine is quickly converted to thiamine pyrophoshate (TPP), the water-soluble, active coenzyme form of vitamin B1.  Benfotiamine - Uses, Side Effects, and More

 

[Wheatwacked]

On 4/14/2023 at 2:29 PM, Dtoc said:

My very unscientific theory to this is, could the 'consistency' of all that gluten, throughout a lifetime, basically gum up the sweat glands?

I wear contact lenses (extended wear, bifocal) and tolerate them well since 1973 (daily wear hard lenses back then.  I would have to take them out to clean the protein buildup at least every two weeks and replace them every two months.  I found that taking them out caused me more irritation than leaving them in.  Since starting gluten free in 2014 I no longer get protein buildup at all and usually get about 6 months 24/7 without removing them.

I suspect that much of what is diagnosed as arthritis is a result of gluten by-products in the synovial fluid.  Same with muscular aches and pains.

I for one buy into your "very unscientific theory"

     "Dry, flaky skin may occur with an iodine deficiency, as the mineral helps your skin cells regenerate. It also helps your body sweat and hydrates your skin cells, so an iodine deficiency can cause you to sweat less.  ...Feeling cold is a common symptom of an iodine deficiency.In fact, some studies have found that over 80% of people with low thyroid hormone levels may feel more sensitive to cold temperatures than usual 10 Signs and Symptoms of Iodine Deficiency"