Positive Deamidated Gliadin IgA

[LiyaK]

Hey all! Just wondering if anyone can shed some light (or if you had similar results). 
 

After eating gluten-free for 3 months, I ate gluten heavily for almost 2 weeks for this blood test (I know it should have ideally been longer) but I’m curious if anyone has had similar results:

Deamidated Gliadin IgA: 29 (weak positive 20-30, strong positive >30)

All other tests came back normal but my total IgA was 335 (range 87-352). 
 

Did any of you have similar numbers and test positive on your biopsy? I haven’t done one yet but I’m just curious if this Deamidated result means anything. 
Thanks!

[Russ H]

Hi Liyak, and welcome to the forum.

The results you have posted indicate isolated raised IgA DGP. This is not in itself very predictive of coeliac disease in adults because your other results (assuming you had IgA tTG measured) were within the standard range. The total IgA result means that you are not IgA deficient, and therefore the standard tests are applicable.

However, 2 weeks is perhaps too short a period to get an accurate result. 4 weeks is typically the shortest period recommended and ideally longer.

 

Edited July 28, 2023 by Russ H

[trents]

It could mean you have celiac disease but it is a less specific test than some others for celiac disease.

[Scott Adams]

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. 

Regarding Deamidated Gliadin IgA:

Quote

The DGP-IgA test is considered to have high sensitivity and specificity. In general, the DGP-IgA test has been reported to have a sensitivity ranging from 75% to 95% and a specificity ranging from 90% to 100%. The DGP tests have been found to have a sensitivity of around 85-95% and a specificity of around 95-98%.