Interpreting results.

[np1209]

Hello! I’m in the process of testing and wanted to see if anyone could help me interpret my results or recommend further testing. It appears my genetic test was positive for DQ2 and DQ7. All other testing was negative and I have been consuming gluten in decent amounts.  I’m interpreting this as being at risk, but likely not positive for a celiac diagnosis? Would love to hear anyone’s insight. Thanks!

GLIADIN AB, DEAMID. IgG: 7

TTG IgA: <1

TTG IgG: <1

GLIADIN AB, DEAMID. IgA: 1

 

hla-dqa1: 05, 05

hla-dqb1: 02:01, 03:01

serologic equivalent: DQ2, DQ7

interpretation: Out of Range

Moderate Risk: Genotype present: HLA-DQ2 (DQA1*05+, DQB1*02+). HLA-DQ2 is associated with genetic susceptibility for celiac disease.

[trents]

Welcome to the forum, @np1209!

Your understanding of the gene testing results is correct. DQ2 and DQ8 are the primary genes associated with the potential to develop celiac disease. My understanding is also that DQ2 alone represents stronger potential than DQ8 alone.

But we need more information with regard to your antibody test results. You need to include not only the raw test scores but the reference ranges. There are no industry standards for reference ranges yet as each lab develops the tests a little differently. Another question I have is are the results you posted above reflective of all antibody tests that were ordered? I don't see a listing for "total IGA" which should always be included so as to check for IGA deficiency. IGA deficiency can result in false negatives on individual IGA antibody tests.

You won't be able to edit your first post so please repost the info with additions.

Edited January 10, 2025 by trents

[np1209]

Hi!

thanks for the quick feedback! I tested negative for DQ8, but did test positive for DQ2 and DQ7. I’m not sure if there’s any information regarding DQ7 and the risk for celiac. I have included the reference ranges for the other labs below. It does not appear that my total IGA was tested. Thanks again. 
 

CELIAC DISEASE PANEL

GLIADIN AB, DEAMID. IgG: 7

INTERPRETIVE INFORMATION:

<15 U/ML NEGATIVE

>=15 U/ML POSITIVE 

TTG IgA: <1

INTERPRETIVE INFORMATION

<15 U/ML: NEGATIVE

>=15 U/ML: POSITIVE 

TTG IgG: <1

INTERPRETIVE INFORMATION

<15 U/ML: NEGATIVE

>=15 U/ML: POSITIVE 

GLIADIN AB, DEAMID. IgA: 1

INTERPRETIVE INFORMATION

<15 U/ML: NEGATIVE

>=15 U/ML: POSITIVE 

[Scott Adams]

Were you eating lots of gluten daily for 6-8 weeks leading up to your blood test? If not, this can cause lower antibody levels, and possibly false negative results.

It's unfortunate that they didn't do a Total IgA count, because if you have naturally low IgA it could lead to false negative test results. The good news is that you could get that test done later and not have to be on a gluten challenge to get those results. 

Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.

 

[trents]

Based on the available test information, it does not appear you have celiac disease. This is a assuming you are not IGA deficient and also assuming your gluten consumption was adequate both in amount and duration in order to ensure valid antibody testing. Guidelines for the "gluten challenge" have recently been revised. It is now recommended that those seeking testing should consume at least 10g of gluten daily for at least two weeks leading up to the day of the blood draw. 10g of gluten is about the amount in 4-6 slices of wheat bread.

Based on the information you have supplied, if you are convinced that gluten is causing symptoms, it would seem you likely have NCGS (Non Celiac Gluten Sensitivity) as opposed to celiac disease. NCGS shares many of the same symptoms of celiac disease but does not damage the lining of the small bowel as does celiac disease. There is no test for it. A diagnosis for NCGS depends on first ruling out celiac disease. It is 10x more common than celiac disease. Some experts feel it can be a precursor to the development of celiac disease. Eliminating gluten from your life is the antidote for NCGS just as it is for celiac disease.