Histamine intolerance and supplements

[Jsingh]

Hi, 

After months of suspecting everything being gluten contaminated, I think it’s histamine intolerance mimicking some glutening symptoms. The biggest thing that settled it was my daughter’s neurological reaction fermented foods and probiotics general. I’ve tried this twice within a gap of six months.

I do recognize now in addition to that avocado, spinach, oranges, and tomatoes absolutely make things worse. 

I see a lot of ppl here having tested their DAO levels via blood test, but I can’t seem to get an allergist to even recognize the condition, let alone to test for it.

Additionally, I was wondering if there was any correlation between nutritional deficiency and histamine intolerance, and if any of you have seen reduction in histamine issues post supplementing. 

Thank you. 
 

[Scott Adams]

Your observations about fermented foods, high-histamine foods (like avocado and tomatoes), and neurological reactions strongly suggest histamine intolerance (HIT), even if it's challenging to get medical confirmation. Since many allergists don't yet recognize HIT as a standard diagnosis, you might have better luck with a functional medicine doctor or naturopath familiar with mast cell disorders—they often order DAO enzyme blood tests or genetic testing for HNMT/DAO mutations. Regarding nutritional connections, several deficiencies can worsen HIT: Low vitamin B6 (needed for DAO production), copper (a DAO cofactor), vitamin C (helps break down histamine), and magnesium (stabilizes mast cells) are common culprits. Many people report improvement after supplementing with these, along with DAO enzyme supplements (like Umbrellux DAO) taken before meals. Quercetin, luteolin, and omega-3s may also help stabilize mast cells over time. Since your daughter reacts to probiotics, avoid histamine-producing strains (e.g., Lactobacillus casei) and opt for low-histamine options (like Bifidobacterium infantis). A low-histamine diet for 4-6 weeks, paired with targeted supplements, often reveals if this is the root issue—just keep a symptom journal to track progress!