Kan-101

[Fabrizio]

Good day , 

I'd like to know if the trial of Anokion for KAN-101 is terminated because it is not working or because they have enough information and data to pass to Phase 3.

Is someone in the trial?

Thanks

[Scott Adams]

KAN‑101 is still very much in development and being actively studied. It has not been dropped—rather, it is advancing through Phases 1 and 2, moving toward what could become the first disease‑modifying treatment for celiac disease.

https://anokion.com/press_releases/anokion-announces-positive-symptom-data-from-its-phase-2-trial-evaluating-kan-101-for-the-treatment-of-celiac-disease/ 

[Fabrizio]

Dear Scott, 

please check the link https://clinicaltrials.gov/study/NCT05574010?intr=KAN-101&rank=1

What do you think about it?

[Scott Adams]

It looks like their most recent clinical trial just finished up on 5-22-2025.

[Fabrizio]

So? What do you think it will go ahead? Did you partecipate to this trial? what's the result for yuo? Thanks a lot for your answers!

[Scott Adams]

I'm not in any clinical trials, can I ask why you are so focused on this particular one? There are now several celiac disease potential treatment drugs undergoing clinical trials.

[Fabrizio]

Hi Scott, i m focused on this because Kan-101 it s very good . Who tested it told me about the special results . Also Tak-101 can be the same . Do you know it?

[Scott Adams]

Yes, we've been tracking possible treatments for many years, and here is one of our more recent articles:

 

[Fabrizio]

Thanks for your article. 

[Shelley22]

On 7/25/2025 at 9:56 AM, Scott Adams said:

KAN‑101 is still very much in development and being actively studied. It has not been dropped—rather, it is advancing through Phases 1 and 2, moving toward what could become the first disease‑modifying treatment for celiac disease.

https://anokion.com/press_releases/anokion-announces-positive-symptom-data-from-its-phase-2-trial-evaluating-kan-101-for-the-treatment-of-celiac-disease/ 

KAN-101 may be dead: https://www.reddit.com/r/Celiac/comments/1mnd628/kan101_is_dead_in_the_water_i_believe/

[Scott Adams]

Another one bites the dust! Oh well...

[Fabrizio]

What do you mean?

[Scott Adams]

This isn't the first potential celiac disease treatment in the pipeline that failed. There have been others...

[chad6]

My Daughter participated in the trial and was cured for her celiac. I was looking forward to some day having the same experience but now the Trial has been terminated. I am trying to figure out if it is because of funding . 

 

It said"The current study required to large a treatment group to provide statistically significant results" 

Trying to figure out if that's code for "we lost our funding" 

[trents]

Here is another one that is currently active. I know someone who has recently signed up to participate in it: https://celiac.org/aspirion-us/

[Scott Adams]

7 hours ago, chad6 said:

My Daughter participated in the trial and was cured for her celiac.

So just to be cautious, there is a big difference between cured, and responding to their medication. I assume you mean that your daughter responded well while taking KAN-101 during the trial, but the drug would not cure celiac disease, but may manage it while you are taking it. Let me know if I got this right.

[RMJ]

16 hours ago, chad6 said:

It said"The current study required to large a treatment group to provide statistically significant results" 

Trying to figure out if that's code for "we lost our funding" 

It is more likely code for “we think there really was a good response to the treatment, but it was small or in a small percent of subjects so it would take a large clinical trial to try to prove it.”

[Scott Adams]

I agree, and generally it means that it isn't working in a high enough percentage of participants to continue pursuing it.