Diabetes Insipidus

[skipper30]

I am looking for anyone out there that might have Diabetes Insipidus.

Is there a "connection" to Celiac??

Thanks in advance!!

[ravenwoodglass]

Check out this page, it is from this site under the heading related disorders

https://www.celiac.com/st_main.html?p_catid...-38106500222.2d

Sorry I just took a closer look and it seems to be mostly info on the corelationship with Type 1.

[2kids4me]

I dont know about a link to celiac but a small percentage of case are autoimmune.

I found this artcle, was interesting:

from: Open Original Shared Link

Recent literature indicates 30% of cases to be idiopathic, 25% related to malignant or benign tumors of the brain or pituitary, 16% secondary to head trauma, and 20% following cranial surgery.

Idiopathic DI is associated with destruction of cells in the hypothalamus, often as part of an autoimmune process. This is characterized by lymphocytic infiltration of the stalk and posterior pituitary. An MRI may show abnormalities of these structures. The presence of antibodies directed against vasopressin cells may help predict the development of central diabetes insipidus.

Familial DI is rare. It is inherited as an autosomal dominant disorder, and mutations involving AVP-neurophysin gene have been identified. Mutations reported to date involve signal peptide region or, more commonly, neurophysin II. The mechanism by which the mutations impair AVP release is not understood but may involve the accumulation of the ADH precursor leading to the death of the ADH-producing cells.

DI after neurosurgery or trauma varies with the extent of damage. Approximately 10-20% of patients will experience DI following transsphenoidal removal of an adenoma. This percentage increases to 60-80% with large tumors. Not all cases of DI are permanent. The most common causes of postoperative polyuria are excretion of excess fluid given during surgery and an osmotic diuresis as a result of treatment for cerebral edema.

Primary intracranial tumors causing DI include craniopharyngioma, or pineal tumors. Appearance of other hypothalamic manifestations may be delayed for as long as 10 years. Thus, periodic follow-up of patients diagnosed with idiopathic DI is necessary to detect slowly growing intracranial lesions.

Other causes include cancer (eg, lung cancer, lymphoma, leukemia), hypoxic encephalopathy, infiltrative disorders (histiocytosis X, sarcoidosis), anorexia nervosa, and vascular lesions such as arteriovenous malformations or aneurysms