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Let's Talk About Depression And Celiac...


JerryK

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JerryK Community Regular

So the way I understand it, from what little research there is to be found, it works like this:

Undigested gluten peptides can "leak" thru the gut. These peptides attach to the opiate receptors of your brain which can lead to the drugged/depressed feelings.

In addition, it's likely your opiate receptors are now blocked by these undigested proteins attached and

your natural endorphins are unable to reach receptors....


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Ursa Major Collaborator

Jerry, have you read the excellent article in Scott's blog? Here is the link Open Original Shared Link

Scroll down to the entry titled "Gluten causes brain disease!" It answers a lot of questions.

JerryK Community Regular

It's likely safe to assume this study was not sponsored by the Wheat Farmers of America.

OMG. j

tarnalberry Community Regular

I think that there's something to the fact that simply feeling like crap for lengthy periods of time will make you feel depressed - in the case of getting 'reglutened', I would think it would be much like a trigger - reminding you of feeling crappy for a long time, which can be *very* depressing.

Nancym Enthusiast

Well, yeah there is that whole peptide thing but then there's also direct damage to the brain. Who knows what else is going on! I think medical science is really in its infancy about this issue.

Corkdarrr Enthusiast

Logically speaking, I'm depressed because I've been in poor health for 10+ years, still don't feel THAT much better after being gluten-free for six months and CF for 1+ months....and I CAN'T EAT ANYTHING. My thyroid is out of whack. My adrenals are out of whack. My neurotransmitters are severely deficient. It's very frustrating. Add to that the majority of the general public thinks you're absolutely insane....seems to me that if you're NOT depressed, something might be wrong! :P

Courtney

plantime Contributor

I know that chronic physical pain causes depression, so it would not surprise me at all if constantly feeling crappy causes depression. I think it is a vicious cycle: first you are always sick, then you get depressed about it, the depression makes the sickness worse, which makes the depression worse....

Breaking the cycle is hard to do. That is where a couple of good doctors would come in.


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    • Scott Adams
      This is a very common question, and the most important thing to know is that no, Guinness is not considered safe for individuals with coeliac disease. While it's fascinating to hear anecdotes from other coeliacs who can drink it without immediate issues, this is a risky exception rather than the rule. The core issue is that Guinness is brewed from barley, which contains gluten, and the standard brewing process does not remove the gluten protein to a level safe for coeliacs (below 20ppm). For someone like you who experiences dermatitis herpetiformis, the reaction is particularly significant. DH is triggered by gluten ingestion, even without immediate gastrointestinal symptoms. So, while you may not feel an instant stomach upset, drinking a gluten-containing beer like Guinness could very well provoke a flare-up of your skin condition days later. It would be a gamble with a potentially uncomfortable and long-lasting consequence. Fortunately, there are excellent, certified gluten-free stouts available now that can provide a safe and satisfying alternative without the risk.
    • MogwaiStripe
      Interestingly, this thought occurred to me last night. I did find that there are studies investigating whether vitamin D deficiency can actually trigger celiac disease.  Source: National Institutes of Health https://pmc.ncbi.nlm.nih.gov/articles/PMC7231074/ 
    • Butch68
      Before being diagnosed coeliac I used to love Guinness. Being made from barley it should be something a coeliac shouldn’t drink. But taking to another coeliac and they can drink it with no ill effects and have heard of others who can drink it too.  is this everyone’s experience?  Can I drink it?  I get dermatitis herpetiformis and don’t get instant reactions to gluten so can’t try it to see for myself. 
    • trents
      NCGS does not cause damage to the small bowel villi so, if indeed you were not skimping on gluten when you had the antibody blood testing done, it is likely you have celiac disease.
    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
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