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Celiac Cure.... A Possible Pill To Cure Celiac

PizzaGuy

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new to LI Newbie
new to LI
Posted

just GI symptoms, and i have never tried after glutened. i always take before eating out. i get very minor queasiness and i know of CC and feel thankful for the pill.

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Nantzie Collaborator
Nantzie
Posted

I might have to give it a shot the next time we go to on one of those trips. What name do your's go by. I've heard of Glutenease and Glutenzyme.

Nancy

new to LI Newbie
new to LI
Posted

hi nancy

i use kirkman labs DPP-IV Forte. it says the activity is 60,000 HUT.

i saw glutenease at the store the other day, when i run out of what i have i was going to try it.

gfp Enthusiast
gfp
Posted
Then there's also the case of the British drug company who did phase 1 trials of a drug designed to block the immune system (to help deal with autoimmune diseases and cancers) which showed no negative side-effects in apes, but nearly killed six of the seven healthy volunteers (elephantosis, kidney, liver, heart, lung and pancreatic damage, and ended up in comas!!) - three of whom now (six months later) have late-stage cancer as a direct side-effect of the trial. We know much less about the human body, immune system and genetic code than we like to think we do.

Yes, I posted this a long time ago...

2kids4me Contributor
2kids4me
Posted

I guess I don't get real excited when a "cure" or pill is in the near future... I was diagnosed with Type 1 diabetes in 1986 and at that time they figured a"cure" was imminent...well here we are 21 years later.......the only cure involves islet cell transplants and you need immune suppressents for that "cure". Diabetes has been researched for years and they still dont know how to stop the immune process from destroying islet cells.

I agree with posters being concerned about side effects from pills...the body is an fine tuned machine. We all know that a food intolerance can wreak havoc ...more so celiac where the immune system goes into high gear against it's host. What will this pill do?

So they found Zonulin affects the intestinal barrier - do they know what else it does?

Autoimmune diseases are tricky bunch - it involves T cells, thymus glands, genetic markers, and the elusive trigger to get it all going.

The proven treatment is to avoid gluten - yes it's a pain and it can be expensive.

The proven treatment for diabetes is insulin (Type 1) ...a bigger pain and expensive.

Systemic Lupus - treat symtoms - no pill or diet can treat it completely because it affects so many organs (including the skin)

MS - ongoing mystery - affects some more than others progresses rapidly or slowly..

Autoimmune hepatitis - treatment is steroids/immune suppressents... whack of side effects there.

and on and on for the long list of autoimmune disorders...

Maybe I am "defeatest"..oh well... I am not going to get all excited about some miracle cure. I will keep truckin along with what I've got and be glad for the good days and hope one day they figure out how to stop the immune system from "attacking self".

Maybe I think differently because I am not going to get my kids all wound up - "they may have a pill soon!" Only to end up 21 years later taking the same "treatment"..... perhaps I do resent being given false hope years ago and then when my son was diagnosed -we were told (again)...a cure is around the corner...so my son comes home thinking by the time he's 16, he wont need insulin. Um, dont think so.........

Sandy

Cam's Mom Contributor
Cam's Mom
Posted

Hi!

Sorry this is kind of a long post but I am includng information sent to me by my brother who is a Pharmacologist, Ph.D. who owns a consulting company in the NY area that helps pharmaceutical companies bring new products to market (amongst other things). He looked into the issue of celiac and diabetes since my daughter (his neice) was recently diagnosed and he is a totally stand up guy. He has mentioned to me that the drugs being developed by Alba are in phase 2 clinical trials. The information put together by his employees includes the following:

"...The rationale is that ingesting an enzyme oral therapy before consuming gluten would break up the gluten into non-toxic food to prevent the triggered immune response and the resulting inflammatory damage.

Although there are no products currently on the market, there are a few that remain in developmental stages. Alvine Pharmaceuticals is researching ALV001 and ALV002 which are oral therapies comprised of enzymes. ALV002 contains both a recombinant cysteine endoprotease found in barley seeds, EP-B2 (breaks down gluten proteins), and prolyl endoprotease, PEP (detoxifies gluten). ALV001 only includes EP-B2, whereas ALV002 contains both enzymes for greater tolerance of gluten in one

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    • trents
      New (possible) celiac diagnosis

      By trents · Posted

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    • Judy M
      New (possible) celiac diagnosis

      By Judy M · Posted

      My husband has had lactose intolerance for his entire life (he's 68 yo).  So, he's used to gastro issues. But for the past year he's been experiencing bouts of diarrhea that last for hours.  He finally went to his gastroenterologist ... several blood tests ruled out other maladies, but his celiac results are suspect.  He is scheduled for an endoscopy and colonoscopy in 2 weeks.  He was told to eat "gluten free" until the tests!!!  I, and he know nothing about this "diet" much less how to navigate his in daily life!! The more I read, the more my head is spinning.  So I guess I have 2 questions.  First, I read on this website that prior to testing, eat gluten so as not to compromise the testing!  Is that true? His primary care doctor told him to eat gluten free prior to testing!  I'm so confused.  Second, I read that celiac disease is genetic or caused by other ways such as surgery.  No family history but Gall bladder removal 7 years ago, maybe?  But how in God's name does something like this crop up and now is so awful he can't go a day without worrying.  He still works in Manhattan and considers himself lucky if he gets there without incident!  Advice from those who know would be appreciated!!!!!!!!!!!!
    • Scott Adams
      Patiently Waiting to See Results

      By Scott Adams · Posted

      You've done an excellent job of meticulously tracking the rash's unpredictable behavior, from its symmetrical spread and stubborn scabbing to the potential triggers you've identified, like the asthma medication and dietary changes. It's particularly telling that the rash seems to flare with wheat consumption, even though your initial blood test was negative—as you've noted, being off wheat before a test can sometimes lead to a false negative, and your description of the other symptoms—joint pain, brain fog, stomach issues—is very compelling. The symmetry of the rash is a crucial detail that often points toward an internal cause, such as an autoimmune response or a systemic reaction, rather than just an external irritant like a plant or mites. I hope your doctor tomorrow takes the time to listen carefully to all of this evidence you've gathered and works with you to find some real answers and effective relief. Don't be discouraged if the rash fluctuates; your detailed history is the most valuable tool you have for getting an accurate diagnosis.
    • Scott Adams
      Gluten free beer ?

      By Scott Adams · Posted

      In this case the beer is excellent, but for those who are super sensitive it is likely better to go the full gluten-free beer route. Lakefront Brewery (another sponsor!) has good gluten-free beer made without any gluten ingredients.
    • trents
      Patiently Waiting to See Results

      By trents · Posted

      Welcome to the forum, @catsrlife! Celiac disease can be diagnosed without committing to a full-blown "gluten challenge" if you get a skin biopsy done during an active outbreak of dermatitis herpetiformis, assuming that is what is causing the rash. There is no other known cause for dermatitis herpetiformis so it is definitive for celiac disease. You would need to find a dermatologist who is familiar with doing the biopsy correctly, however. The samples need to be taken next to the pustules, not on them . . . a mistake many dermatologists make when biopsying for dermatitis herpetiformis. 
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