Please Interpret My Results For Me...

[rynbeth]

In February - when I knew much less about celiac disease and gluten intolerance than I do now - my doctor ran a celiac blood panel on me. Here are my results (click the link for a scan of them).

When I got home and read about how the blood tests frequently come back negative, I sought out the genetic testing from enterolab. Here are my results:

HLA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic equivalent: HLA-DQ 2,3 (Subtype 2,7)

Interpretation Of HLA-DQ Testing: HLA gene analysis reveals that you have one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQ2 or HLA-DQ8. Each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. You also have a non-celiac gene predisposing to gluten sensitivity (DQ1 or DQ3 not subtype 8). Having one celiac gene and one gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of a gluten sensitive gene. Having two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

Can someone interpret these for me, particularly the blood test results, as the gene test results seem pretty clear.

Thank you!!

[CarlaB]

You carry a celiac gene, like 30% of the population does.

You carry a gluten sensitive gene, like almost all the population does (DQ4 is the ONLY non-gluten sensitive gene).

Your celiac tests show no reaction to gluten.

Some people feel better on a gluten-free diet anyway. I do, and all my tests were negative. So, you can try the diet and see if it makes a difference in how you feel.

[hathor]

As CarlaB noted, the gene tests aren't sufficient to tell if you have a problem with gluten or not. If you want something advertised as more sensitive than blood testing, get the stool testing from Enterolab. Or go gluten free and see how you respond ...

[Ursa Major]

All your blood test results are borderline, and you have the genes for both celiac disease and gluten intolerance. If you combine that with celiac disease symptoms, I'd say it would make sense to try the gluten-free diet. If you respond favourably to it, I'd assume you do have celiac disease.