Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Biopsy Results

rebz

Recommended Posts

rebz Rookie
rebz
Posted

Here are my blood results.

total IgA - 4.38 g/L (0.8-2.8 normal range)

Endomysium IgA - negative

IgA gliadin - 35U/mL (15-30U/ml equivocal range)

IgG gliadin - 13 U.mL (15-30U/ml equivocal range)

IgA t-Transglutaminase 22 U/ml (normal range 0-15U/ml)

Biopsy results only showed ' subjective patchy increase in intraepithelial lymphocytes'

I am waiting for an appointment with GI doc to discuss results. Before the biopsy he said he thought it would be negative with these blood results.

I am totally confused - I think he will say that these results don't indicate celiac because there is no villous atrophy etc... I am thinking he will tell me I have IBS. Am I in denial about this do you think or are these results as borderline as I think they are...

Any comments are greatly appreciated

Rebecca

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


2kids4me Contributor
2kids4me
Posted

My daughter had borderline results in bloodwork too, GI said: " Her results are as low as they can get and still be called positive - I am doing the biopsy to rule out celiac as a cause for her intestinal symptoms plus we can get a better idea of what might be going on." [rather than saying - we are doing this to confirm celiac]

Biopsy confirmed celiac - subtotal villous flattening with lymphocytic infiltration.

Lymphocytes are the white blood cell that responds to antigens - be it viral, bacterial or gluten causing an immune response.

I read somewhere that dairy can cause villous blunting as well (if the person is intolerant), but not to the same degree at gluten.

IBS is not a diagnosis - its an adjective to describe inflammed bowel when they dont know the cause /havent found the cause. Many so called "IBS" patients respond very well to gluten free.

We had reduced gluten to one piece of bread or a serving of cereal in the weeks prior to biopsy, Kathryn hated eating that gluten! Even before the results were known, Kathryn decided she never wanted "that evil gluten" again.

Sandy

nikki-uk Enthusiast
nikki-uk
Posted
Here are my blood results.

total IgA - 4.38 g/L (0.8-2.8 normal range)

Endomysium IgA - negative

IgA gliadin - 35U/mL (15-30U/ml equivocal range)

IgG gliadin - 13 U.mL (15-30U/ml equivocal range)

IgA t-Transglutaminase 22 U/ml (normal range 0-15U/ml)

Biopsy results only showed ' subjective patchy increase in intraepithelial lymphocytes'

I am waiting for an appointment with GI doc to discuss results. Before the biopsy he said he thought it would be negative with these blood results.

I am totally confused - I think he will say that these results don't indicate celiac because there is no villous atrophy etc... I am thinking he will tell me I have IBS. Am I in denial about this do you think or are these results as borderline as I think they are...

Any comments are greatly appreciated

Rebecca

It's possible that you've caught it before any real damage occured - or , damage can be patchy and maybe the biopsy sites missed it.

Something must have drove you to the docs in the first place symptom wise - so you've absolutely got nothing to lose by trying the gluten-free diet now you've had the biopsy :)

Nancym Enthusiast
Nancym
Posted
Biopsy results only showed ' subjective patchy increase in intraepithelial lymphocytes'

I believe this is recognized as a pre-celiac changes I think Dr. Lewey, and others, write about this. You might want to google it up.

Here's one: Open Original Shared Link

rebz Rookie
rebz
Posted
  • Author

thank you for your replies.

I shall wait and see what the GI says before making any decision on a gluten-free diet. I am reluctant to start without a definite diagnosis of celiac and these results are not convincing to me, though maybe others would think they are ?

aikiducky Apprentice
aikiducky
Posted

If you decide to not go gluten free at this point, in my opinion you certainly should get another biopsy some time in the future (a year or two). I think it's very likely that you're in the early stages of intestinal damage, and the most sensible thing would be to go gluten free now before any more damage has a chance to happen, but if you don't want to do that, you should have a follow up biopsy later to see if the damage has progressed.

Pauliina

ravenwoodglass Mentor
ravenwoodglass
Posted
Here are my blood results.

IgA t-Transglutaminase 22 U/ml (normal range 0-15U/ml)

Biopsy results only showed ' subjective patchy increase in intraepithelial lymphocytes'

Any comments are greatly appreciated

Rebecca

Those were positive blood tests results. How many biopsies were done? 7 to 9 would be the optimum number but many doctors only take 1 to 3. You have 22 ft of small intestines, early in the disease the damage can be patchy and if the right spot is not biopsied you will not get an accurate result. If you need a good reason to stay gluten-free without a strong positive take a look at my signature. I do not show up in blood work and this delayed my diagnosis by many years. Without a positive blood test they never even thought to do an endo. I will never fully recover my brain function, after 5 years gluten-free what I live with is permanent. And I would not wish it on anyone. We do things backwards so often, doctors wait until damage is severe rather than 'inconvience' someone with a diagnosis that can prevent many other disease from ever showing up.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. knitty kitty
      - knitty kitty replied to lizzie42's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      4

      Son's legs shaking

      Yes, I do think they need a Thiamine supplement at least. Especially since they eat red meat only occasionally. Most fruits and vegetables are not good sources of Thiamine. Legumes (beans) do contain thiamine. Fruits and veggies do have some of the other B vitamins, but thiamine B 1 and Cobalamine B12 are mostly found in meats. Meat, especially organ...
    2. lizzie42
      - lizzie42 replied to lizzie42's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      4

      Son's legs shaking

      Thank you! That's helpful. My kids eat very little processed food. Tons of fruit, vegetables, cheese, eggs and occasional red meat. We do a lot of rice and bean bowls, stir fry, etc. Do you think with all the fruits and vegetables they need a vitamin supplement? I feel like their diet is pretty healthy and balanced with very limited processed food....
    3. Scott Adams
      - Scott Adams replied to Russ H's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      1

      Anti-endomysial Antibody (EMA) Testing

      That is interesting, and it's the first time I heard about the umbilical cord beings used for that test. Thanks for sharing!
    4. knitty kitty
      - knitty kitty replied to lizzie42's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      4

      Son's legs shaking

      @lizzie42, You're being a good mom, seeking answers for your son. Cheers! Subclinical thiamine deficiency commonly occurs with anemia. An outright Thiamine deficiency can be precipitated by the consumption of a high carbohydrate meal. Symptoms of Thiamine deficiency include feeling shakey or wobbly in the legs, muscle weakness or cramps...
    5. Scott Adams
      - Scott Adams replied to Paulaannefthimiou's topic in Gluten-Free Foods, Products, Shopping & Medications
      2

      Bob red mill gluten free oats

      Oats naturally contain a protein called avenin, which is similar to the gluten proteins found in wheat, barley, and rye. While avenin is generally considered safe for most people with celiac disease, some individuals, around 5-10% of celiacs, may also have sensitivity to avenin, leading to symptoms similar to gluten exposure. You may fall into this...
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      132,869
    • Most Online (within 30 mins)
      7,748
    MaryannHall
    Newest Member
    MaryannHall
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • knitty kitty
      Son's legs shaking

      By knitty kitty · Posted

      Yes, I do think they need a Thiamine supplement at least. Especially since they eat red meat only occasionally. Most fruits and vegetables are not good sources of Thiamine.  Legumes (beans) do contain thiamine.  Fruits and veggies do have some of the other B vitamins, but thiamine B 1 and  Cobalamine B12 are mostly found in meats.  Meat, especially organ meats like liver, are the best sources of Thiamine, B12, and the six other B vitamins and important minerals like iron.   Thiamine has antibacterial and antiviral properties.  Thiamine is important to our immune systems.  We need more thiamine when we're physically ill or injured, when we're under stress emotionally, and when we exercise, especially outside in hot weather.  We need thiamine and other B vitamins like Niacin B 3 to keep our gastrointestinal tract healthy.  We can't store thiamine for very long.  We can get low in thiamine within three days.  Symptoms can appear suddenly when a high carbohydrate diet is consumed.  (Rice and beans are high in carbohydrates.)  A twenty percent increase in dietary thiamine causes an eighty percent increase in brain function, so symptoms can wax and wane depending on what one eats.  The earliest symptoms like fatigue and anxiety are easily contributed to other things or life events and dismissed.   Correcting nutritional deficiencies needs to be done quickly, especially in children, so their growth isn't stunted.  Nutritional deficiencies can affect intelligence.  Vitamin D deficiency can cause short stature and poor bone formation.   Is your son taking anything for the anemia?  Is the anemia caused by B12 or iron deficiency?  
    • lizzie42
      Son's legs shaking

      By lizzie42 · Posted

      Thank you! That's helpful. My kids eat very little processed food. Tons of fruit, vegetables, cheese, eggs and occasional red meat. We do a lot of rice and bean bowls, stir fry, etc.  Do you think with all the fruits and vegetables they need a vitamin supplement? I feel like their diet is pretty healthy and balanced with very limited processed food. The only processed food they eat regularly is a bowl of Cheerios here and there.  Could shaking legs be a symptom of just a one-time gluten exposure? I guess there's no way to know for sure if they're getting absolutely zero exposure because they do go to school a couple times a week. We do homeschool but my son does a shared school 2x a week and my daughter does a morning Pre-K 3 x a week.  At home our entire house is strictly gluten free and it is extremely rare for us to eat out. If we eat at someone else's house I usually just bring their food. When we have play dates we bring all the snacks, etc. I try to be really careful since they're still growing. They also, of course, catch kids viruses all the time so I  want to make sure I know whether they're just sick or they've had gluten. It can be pretty confusing when they're pretty young to even be explaining their symptoms! 
    • Scott Adams
      Anti-endomysial Antibody (EMA) Testing

      By Scott Adams · Posted

      That is interesting, and it's the first time I heard about the umbilical cord beings used for that test. Thanks for sharing!
    • knitty kitty
      Son's legs shaking

      By knitty kitty · Posted

      @lizzie42, You're being a good mom, seeking answers for your son.  Cheers! Subclinical thiamine deficiency commonly occurs with anemia.  An outright Thiamine deficiency can be precipitated by the consumption of a high carbohydrate meal.   Symptoms of Thiamine deficiency include feeling shakey or wobbly in the legs, muscle weakness or cramps, as well as aggression and irritability, confusion, mood swings and behavior changes.  Thiamine is essential to the production of neurotransmitters like serotonin and dopamine which keep us calm and rational.   @Jsingh, histamine intolerance is also a symptom of Thiamine deficiency.  Thiamine is needed to prevent mast cells from releasing histamine at the slightest provocation as is seen in histamine intolerance.  Thiamine and the other B vitamins and Vitamin C are needed to clear histamine from the body.  Without sufficient thiamine and other B vitamins to clear it, the histamine builds up.  High histamine levels can change behavior, too.  High histamine levels are found in the brains of patients with schizophrenia.  Thiamine deficiency can also cause extreme hunger or conversely anorexia.   High carbohydrate meals can precipitate thiamine deficiency because additional thiamine is required to process carbohydrates for the body to use as fuel.  The more carbohydrates one eats daily, the more one needs additional thiamine above the RDA.  Thiamine is water soluble, safe and nontoxic even in high doses. Keep in mind that gluten-free processed foods like cookies and such are not required to be fortified and enriched with vitamins and minerals like their gluten containing counterparts are.  Limit processed gluten-free foods.  They are often full of empty calories and unhealthy saturated fats and additives, and are high in histamine or histamine release triggers.  It's time you bought your own vitamins to supplement what is not being absorbed due to malabsorption of Celiac disease.  Benfotiamine is a form of Thiamine that has been shown to improve intestinal health as well as brain function. Do talk to your doctors and dieticians about supplementing with the essential vitamins and minerals while your children are growing up gluten free.  Serve nutritionally dense foods.  Meats and liver are great sources of B vitamins and minerals. Hope this helps!  Keep us posted on your progress!
    • Scott Adams
      Bob red mill gluten free oats

      By Scott Adams · Posted

      Oats naturally contain a protein called avenin, which is similar to the gluten proteins found in wheat, barley, and rye. While avenin is generally considered safe for most people with celiac disease, some individuals, around 5-10% of celiacs, may also have sensitivity to avenin, leading to symptoms similar to gluten exposure. You may fall into this category, and eliminating them is the best way to figure this out. Some people substitute gluten-free quinoa flakes for oats if they want a hot cereal substitute. If you are interested in summaries of scientific publications on the topic of oats and celiac disease, we have an entire category dedicated to it which is here: https://www.celiac.com/celiac-disease/oats-and-celiac-disease-are-they-gluten-free/   
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.