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jmd3

Test Results - Help - I Need The Gluten Smartie Police

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My DH had a test several weeks ago, and we were finally called today.

The nurse told me that they don't understand the test and had to call someone to figure out what it meant. And they are still confused.

On the paper with the test results it says :

" Tell patient he has a genes found in people + celiac disease (gluten allergy) However, it can be found in the normal population as well If having diarrhea or joint pain Try gluten - free diet otherwise NTD " I can't believe he called it a gluten allergy - ???? The doc wants me to call the hospital lab for interpretation ( they are closed )

Now we don't eat gluten in our house anymore - because of myself being celiac and my daughter too. So he shouldn't have any antibodies?? Now he does occasionally eat gluten when out, but very, very rarely.

It has the two genes - off to the side Celiac Genetic HLA-DQ2/DQ8

But the other tests they took :

HLA Class II

Donor DNR

DR Locus - 7, 12

DRW Locus 52, 53

DQ Locus 2, 7

Method PCR

Can someone tell me what the test results mean, and what Locus is please? When I had the test results it came back in different form.

thanks in advance!


Feb 9, 07 - Positive gene test D2 -Celiac Disease and Positive D3 for Gluten Sensitivity-Double Whammy!

Positive blood test for antibodies for celiac

SEVERE Gluten Ataxia - trouble speaking - could not even turn my head side to side - almost bedridden

March 07 - 2 different doctors have documented my records as confirmed Celiac

Oct 07 - found a secret to feeling better - no processed foods - The healing comes from eating raw vegetables, and fruits!

Husband - tested = celiac gene+diabetes gene

3 children-

youngest - doc wont test has w/ Hashimoto Disease

middle- tested = celiac gene+lymphoma gene - dx-celiac

oldest - ignores warnings

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HLA Class II =

major HLA antigens are essential elements in immune function:

Different classes have different functions

Class I antigens (A, B & C) - Present peptides from inside the cell (including viral peptides if present)

Class II antigens (DR, DP, & DQ) - Present phagocytosed antigens from outside of the cell to T-lymphocytes

Locus: In biology and evolutionary computation, a locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map. http://en.wikipedia.org/wiki/Locus_%28genetics%29

Looks to me like he is positive for HLA DQ 2.

http://en.wikipedia.org/wiki/HLA_DQ

Which lab did the tests?

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HLA Class II =

major HLA antigens are essential elements in immune function:

Different classes have different functions

Class I antigens (A, B & C) - Present peptides from inside the cell (including viral peptides if present)

Class II antigens (DR, DP, & DQ) - Present phagocytosed antigens from outside of the cell to T-lymphocytes

Locus: In biology and evolutionary computation, a locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map. http://en.wikipedia.org/wiki/Locus_%28genetics%29

Looks to me like he is positive for HLA DQ 2.

http://en.wikipedia.org/wiki/HLA_DQ

Which lab did the tests?

Thank-you, I will check out the urls

The mayo clinic ran the test for our local hospital

Does this mean he does have celiac, or just the gene, we are so confused. He doesn't really have any symptoms, but we were trying to figure out just how bad our kids could be by putting our genes together. He asked the doc for the test, and he said ok, but noone knows what it means....humm

The doctor doesn't know what to say to him or what to do unless he has joint pain or diarrhea. i guess he's done his job. He had the blood work drawn back in Oct, he has had the test results since 11/1 back, we just found out today.

Our hospitial lab doesn't usually give results, the day he took the test, they didn't even know what the test was.


Feb 9, 07 - Positive gene test D2 -Celiac Disease and Positive D3 for Gluten Sensitivity-Double Whammy!

Positive blood test for antibodies for celiac

SEVERE Gluten Ataxia - trouble speaking - could not even turn my head side to side - almost bedridden

March 07 - 2 different doctors have documented my records as confirmed Celiac

Oct 07 - found a secret to feeling better - no processed foods - The healing comes from eating raw vegetables, and fruits!

Husband - tested = celiac gene+diabetes gene

3 children-

youngest - doc wont test has w/ Hashimoto Disease

middle- tested = celiac gene+lymphoma gene - dx-celiac

oldest - ignores warnings

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It just means he has the genes for potentially developing celiac. It doesn't mean he will necessarily ever actually have celiac, just that he has the right genes for it. About 30% (or something close to that number) of the population has these genes, but obviously not all of those people have celiac.

Celiac doesn't get inherited in a straightforward way like blue or brown eyes, so you can't really tell from parents genes how much of a risk your children have of developing it.

They didn't test for antibodies at least from what you posted above, just the genes.

Pauliina

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Sounds like he has DQ2 and 7 and no other tests were done. They do not mean much as 30-40% have these genes.

nora


gluten-free since may 06 after neg. biopsy symptoms went away and DH symptoms which I had since 03 got gradually better.

daughter officially diagnosed celiac and casein intolerant.

non-DQ2 or DQ8. Maybe DQ1? Updated: Yes, double DQ5

Hypothyroid since 2000, thyroxine first started to work well 06 on a low-carb and gluten-free diet

Lost 20 kg after going gluten-free and weighing 53 kg now. neg. biopsy for DH. Found out afterwards from this forum that it should have been taken during an outbreak but it was taken two weeks after. vitaminD was 57 nmol/l in may08)

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" Tell patient he has a genes found in people + celiac disease (gluten allergy) However, it can be found in the normal population as well If having diarrhea or joint pain Try gluten - free diet otherwise NTD " I can't believe he called it a gluten allergy - ???? The doc wants me to call the hospital lab for interpretation ( they are closed )

I would interpret this as saying:

"Tell patient he has a genes found in people + celiac disease (gluten allergy)"

We found the gene and also the antibody reaction.

This:

"However, it can be found in the normal population as well"

Or in forms of illness that we don't yet recognize as gluten induced.

and this:

"If having diarrhea or joint pain Try gluten - free diet otherwise NTD"

If your not having symptoms that we clearly recognize as gluten just eat gluten till you do. Once you do get noticeablly sick then you can do the diet.

Unfortunately the damage done to nervous systems, brain, liver and other body functions can be seriously effected long before GI symptoms get severe or before doctors recognize that the joint pain is more than 'normal' with aging.

You say your DH is gluten light? He may want to try being totally gluten free for a bit. He may end up being amazed how many 'annoying' little things are not there anymore.


Courage does not always roar, sometimes courage is the quiet voice at the end of the day saying

"I will try again tommorrow" (Mary Anne Radmacher)

Diagnosed by Allergist with elimination diet and diagnosis confirmed by GI in 2002

Misdiagnoses for 15 years were IBS-D, ataxia, migraines, anxiety, depression, fibromyalgia, parathesias, arthritis, livedo reticularis, hairloss, premature menopause, osteoporosis, kidney damage, diverticulosis, prediabetes and ulcers, dermatitis herpeformis

All bold resoved or went into remission in time with proper diagnosis of Celiac November 2002

 Gene Test Aug 2007

HLA-DQB1 Molecular analysis, Allele 1 0303

HLA-DQB1 Molecular analysis, Allele 2 0303

Serologic equivalent: HLA-DQ 3,3 (Subtype 9,9)

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If your not having symptoms that we clearly recognize as gluten just eat gluten till you do. Once you do get noticeablly sick then you can do the diet.

Unfortunately the damage done to nervous systems, brain, liver and other body functions can be seriously effected long before GI symptoms get severe or before doctors recognize that the joint pain is more than 'normal' with aging.

HOW TRUE -This is me - AND so many others here on this site! Thanks - you interpreted everything they said just perfect, I understand that! And amazingly how true it was! Thank-you again!

You say your DH is gluten light? He may want to try being totally gluten free for a bit. He may end up being amazed how many 'annoying' little things are not there anymore.

Yes, hubby is gluten light, we have no gluten in the house...but he does eat wheat at work - however - he will be off work for several months - His buddies sent him a care box of gluten goodies with cheeses and meat snacks because I make nothing or have anything with gluten here!! We already removed those goodies to send back to his work to put into the cafeteria for others to snack on.

He will not have gluten for at least 2 full months, we will see what happens


Feb 9, 07 - Positive gene test D2 -Celiac Disease and Positive D3 for Gluten Sensitivity-Double Whammy!

Positive blood test for antibodies for celiac

SEVERE Gluten Ataxia - trouble speaking - could not even turn my head side to side - almost bedridden

March 07 - 2 different doctors have documented my records as confirmed Celiac

Oct 07 - found a secret to feeling better - no processed foods - The healing comes from eating raw vegetables, and fruits!

Husband - tested = celiac gene+diabetes gene

3 children-

youngest - doc wont test has w/ Hashimoto Disease

middle- tested = celiac gene+lymphoma gene - dx-celiac

oldest - ignores warnings

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