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Help With Understanding Blood Test

heartofgold

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heartofgold Rookie
heartofgold
Posted

I am in ontario canada so i am not sure how to read these tests meaning i have seen some blood tests posted but I could not compare anything cause the labs may post differently here. LIke you said maybe someone can help me on it here .

Gliadin AB IgG 36 H (which is high i am sure ) then it says 20 KEU/L CMH

Gliadin Ab IgA 21 H 20 KEU/L CMH

tTransglut IgA 45 H 20 KEU?L CMH

Interpretation Positive findings of IgA Endomystal antibodies (IgA Transglutaminese) are essentially diagnostic of Celiac Disease or Dermatitis Herpatiformis. The IgA Endomystal antibodies should disappear with a strict adherence to a gluten free diet and can be used to monitor adherence to diet.

*** i know i dont have the D.H. skin disease.

Again i hope someone can interrupt this as it is a canadian hospital that did them.

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ravenwoodglass Mentor
ravenwoodglass
Posted

Those are postive blood tests.

Most likely they are read thus

Tests run- Your result- High or Low - Top of normal range

Gliadin AB IgG -36 -H -20 KEU/L CMH

Gliadin Ab IgA -21 -H - 20 KEU/L CMH

tTransglut IgA -45 -H -20 KEU?L CMH

kaiess Contributor
kaiess
Posted

I'm not one to give advice yet, b/c we're right there with you on this one, but I do remember our gastro telling us that normal TTG is under 20 and my son had a first reading of 95 and a second reading of 145 (6 months after the first). We are in BC so I assume they have the same tests as Ont. My son was scoped after the first reading of 95 and it was negative. Even after the 145 reading they still would not diagnose him with Celiac. Instead we have just done a 3rd reading (12 months after the first) and I am awaiting results. They said if it is over 200 then that is a definite Celiac diagnosis, but again they will want to diagnose with a scope/biopsy.

Not sure if I'm any help as far as your testing.

Kathy

mamaw Community Regular
mamaw
Posted

I agree with Ravenwoodglass... you should be gluten free

heartofgold Rookie
heartofgold
Posted
  • Author

Those are postive blood tests.

Most likely they are read thus

Tests run- Your result- High or Low - Top of normal range

Gliadin AB IgG -36 -H -20 KEU/L CMH

Gliadin Ab IgA -21 -H - 20 KEU/L CMH

tTransglut IgA -45 -H -20 KEU?L CMH

[/quote

hi Raven. do you mean that the highest normal in general is -20 so thus the -35 and -45 are fairly high showing celiac disease in my blood tests . thanks again.

heartofgold Rookie
heartofgold
Posted
  • Author
I'm not one to give advice yet, b/c we're right there with you on this one, but I do remember our gastro telling us that normal TTG is under 20 and my son had a first reading of 95 and a second reading of 145 (6 months after the first). We are in BC so I assume they have the same tests as Ont. My son was scoped after the first reading of 95 and it was negative. Even after the 145 reading they still would not diagnose him with Celiac. Instead we have just done a 3rd reading (12 months after the first) and I am awaiting results. They said if it is over 200 then that is a definite Celiac diagnosis, but again they will want to diagnose with a scope/biopsy.

Not sure if I'm any help as far as your testing.

Kathy

hi kathy.... i read a posting a doctor had online about the fact we have 22 feet of small intestines so when they do biopsy they might not hit right on the gluten effected area. so we could in essence be biopsied over and over . the blood tests are suppose to be 90% right so i think if our numbers are up we do have problems with gluten thus gluten free diet. i did not want to go back for a second biopsy right now so i went gluten free. hope i am doing it as well as i can though as i am so new at it last 3 weeks. thanks for helping me with the blood test results.

ravenwoodglass Mentor
ravenwoodglass
Posted
hi Raven. do you mean that the highest normal in general is -20 so thus the -35 and -45 are fairly high showing celiac disease in my blood tests . thanks again.

Yes, that's correct.

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    • Scott Adams
      Test interpretations

      By Scott Adams · Posted

      Based on those results alone, it’s not possible to say you have celiac disease. The test that is usually most specific for celiac, tTG-IgA, is negative in your results, and the endomysial antibody (EMA) is also negative, which generally argues against active celiac disease. However, your deamidated gliadin IgA is elevated, and your total IgA level is also high, which can sometimes affect how the other antibody tests behave. Another important factor is that you were reducing gluten before the test, which can lower antibody levels and make the results less reliable. Because of that, many doctors recommend a gluten challenge (eating gluten regularly for several weeks) before repeating blood tests or considering an endoscopy if symptoms and labs raise concern. It would be best to review these results with a gastroenterologist, who can interpret them in context and decide whether further testing is needed.
    • trents
      Test interpretations

      By trents · Posted

      Since you compromised the validity of the antibody testing by experimenting with gluten withdrawal ahead of the testing, you are faced with two options: 1. Reintroduce significant amounts of gluten into your diet for a period of weeks, i.e., undertake a "gluten challenge". The most recent guidelines are the daily consumption of at least 10g of gluten (about the amount found in 4-6 slices of wheat-based bread) for at least two weeks leading up to the day of testing. Note: I would certainly give it more than two weeks to be sure. 2. Be willing to live with the ambiguity of not knowing whether gluten causes you problems because you have celiac disease or NCGS (Non Celiac Gluten Sensitivity). There is no test for NCGS. Celiac disease must first be ruled out and we have tests for it. Celiac disease has an autoimmune base. NCGS does not. GI symptoms overlap. In the early stages of celiac disease, other body systems may not be showing stress or damage so, symptomatically, it would be difficult to distinguish between celiac disease and NCGS. Both conditions require elimination of gluten from the diet for symptom relief. Some experts feel that NCGS can be a precursor to celiac disease.
    • suek54
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      Hi Kayla Huge sympathies. I was diagnosed in December, after 8 months of the most awful rash, literally top to toe. Mine is a work in progress. Im on just 50mg dapsone at the moment but probably need an increased dose to properly put the lid on it. As you have been now glutened, I wondered whether it might be worth asking for a skin biopsy to finally get a proper diagnosis? Sue  
    • MicG
      Test interpretations

      By MicG · Posted

      I had been eating reduced gluten until about 3 days before the test. I did realize that wasn’t ideal, but it was experimental to see if gluten was actually bothering me. One slip up with soy sauce and it was quite clear to me that it was, lol. 
    • trents
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