Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Understanding Lab Test Values

GlutenGuy36

Recommended Posts

GlutenGuy36 Contributor
GlutenGuy36
Posted

Hi I was diagnosed with Celiac Disease on July 14th 2008. I never really understood my lab values so maybe some of you out there that understand it better than me can help me out here. My Celiac Disease Panel with Reflex to Titer, Immunoglobulin A, Serum was 577 mg/dl. I know this is high because it is marked as such with the reference range being 68-378.

The one I don't understand is the Tissue Transglutaminase Ab,IgA which was <20. I don't see a reference range for this one just the number value. So if someone knows about this please send me a reply. I appreciate it.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


oceangirl Collaborator
oceangirl
Posted

Hi,

I'm not gifted at this so hopefully others will post, but in the ranges given for my anti-tissue transglutiminase test, 19 and under was in the normal range, 20 and over would be in a the positive range.

lisa

GlutenGuy36 Contributor
GlutenGuy36
Posted
  • Author
Hi,

I'm not gifted at this so hopefully others will post, but in the ranges given for my anti-tissue transglutiminase test, 19 and under was in the normal range, 20 and over would be in a the positive range.

lisa

Ok, I wasn't quite sure what that <20 meant. Thanks for the help.

happygirl Collaborator
happygirl
Posted

Did you have a positive biopsy?

According to what you posted, you were negative on the tTG IgA test, and you had an elevated total IgA count (which is not a Celiac test, but part of the panel to differentiate if you have an IgA deficiency). Was there other bloodwork run?

GlutenGuy36 Contributor
GlutenGuy36
Posted
  • Author
Did you have a positive biopsy?

According to what you posted, you were negative on the tTG IgA test, and you had an elevated total IgA count (which is not a Celiac test, but part of the panel to differentiate if you have an IgA deficiency). Was there other bloodwork run?

No, my bi-opsies were inconclusive. I don't know how other than your small intestine is 25 ft long and maybe the areas he took them from were fine. I was having horrible abdominal pains.

It says right on my lab sheet: presence of IgA antibodies against human tTG suggests the possibility of certain gluten sensitive enteropathies such as Celiac Disease and dermetitis herpetiformis.

happygirl Collaborator
happygirl
Posted

Do you have your pathology report from your biopsy?

It may be helpful to find out the reference range from your lab for the tTG.

GlutenGuy36 Contributor
GlutenGuy36
Posted
  • Author
Do you have your pathology report from your biopsy?

It may be helpful to find out the reference range from your lab for the tTG.

Yes, I will find it and post it on here later. I have to dig through some files.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


GlutenGuy36 Contributor
GlutenGuy36
Posted
  • Author
Do you have your pathology report from your biopsy?

It may be helpful to find out the reference range from your lab for the tTG.

Ok I found my pathology report. They did five bi-opsies. They were of: 1. Termial Ileum (small bowel mucosal with mild specific colonic inflammation), 2. Right Colon ( Colonic mucosa with lymphoid aggregate and mild nonspecific inflammation), 3. Transverse Colon (Colonic mucosa with lymphoid aggregate and mild non specific inflammation), 4. Left Colon ( Colonic mucosa with mild nonspecific inflammation), 5. Rectum ( Colonic mucosa with lymphoid aggregate and mild non specific chronic inflammation.

I also had a Duodenum Giemsa stain which was negative for organisms but the biopsy showed mild nonspecific chronic inflammation. Stomach Biopsy showed mild chronic inflammation, and Giemsa stain was negative for helicobacter organisms.

This is all that is on the two sheets that I have. I don't see a reference range on these to sheets. The other one that I first commented on had a reference IgA range of 68-378 and my value was 577.

It says this: Presence of IgA antibodies against human tTG suggests the possibility of gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis.

Ok now I see here that my Tissue Transglutaminase ab, IgA is 2 units < 20.

Thanks for your help happy girl. I am just wondering why I still don't feel well after a year gluten free.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. knitty kitty
      - knitty kitty replied to pothosqueen's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      16

      Positive biopsy

      In the study linked above, the little girl switched to a gluten free diet and gained enough weight that that fat pad was replenished and surgery was not needed. Here's the full article link... Superior Mesenteric Artery Syndrome in a 6-Year-Old Girl with Final Diagnosis of Celiac Disease https://pmc.ncbi.nlm.nih.gov/articles/PMC6476019/
    2. knitty kitty
      - knitty kitty replied to Jordan Carlson's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      1

      Fruits & Veggies

      Hello, @Jordan Carlson, So glad you're feeling better. Tecta is a proton pump inhibitor. PPI's also interfere with the production of the intrinsic factor needed to absorb Vitamin B12. Increasing the amount of B12 you supplement has helped overcome the lack of intrinsic factor needed to absorb B12. Proton pump inhibitors also reduce the...
    3. knitty kitty
      - knitty kitty replied to pothosqueen's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      16

      Positive biopsy

      @pothosqueen, Welcome to the tribe! You'll want to get checked for nutritional deficiencies and start on supplementation of B vitamins, especially Thiamine Vitamin B 1. There's some scientific evidence that the fat pad that buffers the aorta which disappears in SMA is caused by deficiency in Thiamine. In Thiamine deficiency, the body...
    4. Scott Adams
      0

      Inmate with Celiac Disease Wins $630,000 After Jail Denies Gluten-Free Food

    5. trents
      - trents replied to pothosqueen's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      16

      Positive biopsy

      Wow! You're pretty young to have a diagnosis of SMA syndrome. But youth also has its advantages when it comes to healing, without a doubt. You might be surprised to find out how your health improves and how much better you feel once you eliminate gluten from your diet. Celiac disease is an autoimmune disorder that, when gluten is consumed, triggers an...
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      133,016
    • Most Online (within 30 mins)
      7,748
    HONEYSUCKLE
    Newest Member
    HONEYSUCKLE
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • knitty kitty
      Positive biopsy

      By knitty kitty · Posted

      In the study linked above, the little girl switched to a gluten free diet and gained enough weight that that fat pad was replenished and surgery was not needed.   Here's the full article link... Superior Mesenteric Artery Syndrome in a 6-Year-Old Girl with Final Diagnosis of Celiac Disease https://pmc.ncbi.nlm.nih.gov/articles/PMC6476019/
    • knitty kitty
      Fruits & Veggies

      By knitty kitty · Posted

      Hello, @Jordan Carlson, So glad you're feeling better.   Tecta is a proton pump inhibitor.  PPI's also interfere with the production of the intrinsic factor needed to absorb Vitamin B12.  Increasing the amount of B12 you supplement has helped overcome the lack of intrinsic factor needed to absorb B12. Proton pump inhibitors also reduce the production of digestive juices (stomach acids).  This results in foods not being digested thoroughly.  If foods are not digested sufficiently, the vitamins and other nutrients aren't released from the food, and the body cannot absorb them.  This sets up a vicious cycle. Acid reflux and Gerd are actually symptoms of producing too little stomach acid.  Insufficient stomach acid production is seen with Thiamine and Niacin deficiencies.  PPI's like Tecta also block the transporters that pull Thiamine into cells, preventing absorption of thiamine.  Other symptoms of Thiamine deficiency are difficulty swallowing, gagging, problems with food texture, dysphagia. Other symptoms of Thiamine deficiency are symptoms of ADHD and anxiety.  Vyvanse also blocks thiamine transporters contributing further to Thiamine deficiency.  Pristiq has been shown to work better if thiamine is supplemented at the same time because thiamine is needed to make serotonin.  Doctors don't recognize anxiety and depression and adult onset ADHD as early symptoms of Thiamine deficiency. Stomach acid is needed to digest Vitamin C (ascorbic acid) in fruits and vegetables.  Ascorbic acid left undigested can cause intestinal upsets, anxiety, and heart palpitations.   Yes, a child can be born with nutritional deficiencies if the parents were deficient.  Parents who are thiamine deficient have offspring with fewer thiamine transporters on cell surfaces, making thiamine deficiency easier to develop in the children.  A person can struggle along for years with subclinical vitamin deficiencies.  Been here, done this.  Please consider supplementing with Thiamine in the form TTFD (tetrahydrofurfuryl disulfide) which helps immensely with dysphagia and neurological symptoms like anxiety, depression, and ADHD symptoms.  Benfotiamine helps with improving intestinal health.  A B Complex and NeuroMag (a magnesium supplement), and Vitamin D are needed also.
    • knitty kitty
      Positive biopsy

      By knitty kitty · Posted

      @pothosqueen, Welcome to the tribe! You'll want to get checked for nutritional deficiencies and start on supplementation of B vitamins, especially Thiamine Vitamin B 1.   There's some scientific evidence that the fat pad that buffers the aorta which disappears in SMA is caused by deficiency in Thiamine.   In Thiamine deficiency, the body burns its stored fat as a source of fuel.  That fat pad between the aorta and digestive system gets used as fuel, too. Ask for an Erythrocyte Transketolace Activity test to look for thiamine deficiency.  Correction of thiamine deficiency can help restore that fat pad.   Best wishes for your recovery!   Interesting Reading: Superior Mesenteric Artery Syndrome in a 6-Year-Old Girl with Final Diagnosis of Celiac Disease https://pubmed.ncbi.nlm.nih.gov/31089433/#:~:text=Affiliations,tissue and results in SMAS.  
    • trents
      Positive biopsy

      By trents · Posted

      Wow! You're pretty young to have a diagnosis of SMA syndrome. But youth also has its advantages when it comes to healing, without a doubt. You might be surprised to find out how your health improves and how much better you feel once you eliminate gluten from your diet. Celiac disease is an autoimmune disorder that, when gluten is consumed, triggers an attack on the villous lining of the small bowel. This is the section of the intestines where all our nutrition is absorbed. It is made up of billions of tiny finger-like projections that create a tremendous surface area for absorbing nutrients. For the person with celiac disease, unchecked gluten consumption generates inflammation that wears down these fingers and, over time, greatly reduces the nutrient absorbing efficiency of the small bowel lining. This can generate a whole host of other nutrient deficiency related medical problems. We also now know that the autoimmune reaction to gluten is not necessarily limited to the lining of the small bowel such that celiac disease can damage other body systems and organs such as the liver and the joints and cause neurological problems.  It can take around two years for the villous lining to completely heal but most people start feeling better well before then. It's also important to realize that celiac disease can cause intolerance to some other foods whose protein structures are similar to gluten. Chief among them are dairy and oats but also eggs, corn and soy. Just keep that in mind.
    • pothosqueen
      Positive biopsy

      By pothosqueen · Posted

      26F!
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.