Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Can You Have Half A Dq8?


val01

Recommended Posts

val01 Newbie

Hi All,

I think that my subject topic covers my question. Can you have a half of a DQ8 (really asking on the alpha side)? Thanks so much!

Valerie


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



nora-n Rookie

The alpha chain is usually 03* but some can have 05* in the alpha chain as far as I can see....was that yhour question? the 05* alpha chain is quite celiac predisposing.

1 % of DQ8 can have this 05* alpha chain.

But your question sounds more like asking if you can still be DQ8 but only have half Dq8, like the 03* alpha chain, and wether the 03* alpha chain matters.

I will keep reading on it, since the half-gene issue has gotten more attention recently, insomuch that many labs now, except enterolab, started testing the alpha chains.

Here is more on DQ8 Open Original Shared Link and here in scandinavia and the german regions it is very frequent.

Which lab did your test?

if it is any lab ogher than enterolab, they might have your alpha chains, but did not tell you.

In teh articlea bout DQ7 and Sicily and celiac, maybe there is some answer to your question, but I will have to go and read it again.

Dq7, 8 and 9 differ just by one base they point out.

val01 Newbie

Hi Nora,

Enterolab did my testing. I was debating whether I wanted to pay to have Promethus to do the DQ2/DQ8 test. I am very confused about my DQ 1,4 result as I am Irish, German, and British. When I asked about the DQ4, I understand that it's not limited to Asians but it's uncommon in Caucasians - and it's uncommon for with my ethnic background not to have at least one DQ2/DQ8 from what I understand. I was thinking perhaps there was an error maybe.

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Anti-gliadin IgA: 17 Units

Fecal Anti-tissue Transglutaminase IgA: 10 Units

Quantitative Microscopic Fecal Fat Score: Less than 300 Units

Fecal Anti-casein (cow's milk) IgA: 8 Units

HLA-DQB1 Molecular analysis, Allele 1: 0502

HLA-DQB1 Molecular analysis, Allele 2: 0402

Serologic equivalent: HLA-DQ 1,4 (Subtype 5,4)

I have never heard of anyone having the DQ8 on the alpha side - just a half of a DQ8, like the DQ2 halves you hear about.

I have read through Wikipedia on DQ4, DQ1. I also found this link - Open Original Shared Link

I know this references diabetes, but I was mainly looking at the allelle patterns on Page 3. For example, you can have DQA1*0301, DQB1*0402 or DQA1 *0401, DQB1*0402 for DQ4, and for DQ1 - DQA1 *0102, DQB1 *0502. So, if you had DQA1*0301, could you have a half of DQ8 on the alpha side?

I hope I am making sense. Thank you for assistance.

Valerie

nora-n Rookie

yes, maybe 03* alpha could be half DQ8, or DQ3 maybe.

There was someone here who had a diagnosis some years back, and then got her genes tested for curiosity, and a child had DQ8, but tested negative.

She then contacted the lab and they re-did the test, I mean sent it on, and they found the DQ8. I guess the DQ8 is harder to find. Wikipedia says so too.

If you read around on DQ2 on wikipedia, there are some really strange DQ2 too. (they are now gone from the wikipedia page I think)

The person with the elusive DQ8 that had to be sent on, she said she also sent to enterolab and they found it no problem.

Yes, you should have some other gene than DQ4 with those acestors, and you should have a high chance of having DQ2 or 8. But some most have those other genes...

Here is the article about DQ7,8 and 9 (they have the 0301 alpha chain)

Archived

This topic is now archived and is closed to further replies.

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Recent Activity

    1. - trents replied to Colleen H's topic in Gluten-Free Foods, Products, Shopping & Medications
      10

      Ibuprofen

    2. - Colleen H replied to Colleen H's topic in Gluten-Free Foods, Products, Shopping & Medications
      10

      Ibuprofen

    3. - Colleen H posted a topic in Coping with Celiac Disease
      0

      Oh my goodness medication causing pain !!!!

    4. - Colleen H replied to Colleen H's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      Stomach burning and neuropathy


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      131,847
    • Most Online (within 30 mins)
      7,748

    rossick11
    Newest Member
    rossick11
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • trents
      Yes, some people do get withdrawal from gluten but gluten withdrawal doesn't usually cause gut pain. Maybe more like general body aches and discomfort. We have articles on gluten withdrawal on this forum. You might do a search for them. Applesauce is very acidic and some brands have added vitamin C (ascorbic acid) which makes them more acidic. This can damage the stomach lining if you eat it too often. Especially if your stomach lining is already compromised. Ibuprofen inhibits the body's ability to rebuild the stomach's protective mucosal lining. That's why it can cause peptic ulcers. As strange as it may sound, low level irritation/inflammation stimulates the body to rebuild the stomach lining. There are two steps in this rebuilding process known as COX 1 and COX 2. Ibuprofen represses both COX 1 and COX 2. Celecoxcib, a prescription anti inflammatory, inhibits only COX 2, making it less likely to cause damage to the gut lining.
    • Colleen H
      Do you or anyone know alot about ibuprofen  I wasn't sure if I was eating too much apple sauce.   Something is making my pain so much worse  I'm referring to the intense pins and needles in my feet and lower legs.  Jaw actually has tardive dystonia and muscle spasms throughout my back Almost like an opposite effect that a pain reliever would do. I'm fairly new to this. Whatever is going on seems to be worsening  Do people get a withdrawal effect from gluten?  It's extremely painful 😖  I'll post that question or research on the site  Thank you everyone for responding 
    • Colleen H
    • Colleen H
      I think I found a huge culprit for severe reactions to create worsening of my c symptoms. Do people with celiac have sensitivity and /or have opposite reaction to certain medications Where can I find a list ?  I'm new here I'm.wondering why I am getting worse when I take certain medicine...the burning feet.  Rebound muscle pain so intense  How many people get opposite effects or have a horrible attack after these meds
    • Colleen H
      Does anyone know if that includes scrambled eggs and healthy smart butter (,gluten free) I add a very tiny amount of margarine less than a teaspoon.  I did no't have any bread    It just seems like no matter what I eat my stomach and nerves over fire and here comes a host of horrible symptoms. My lower abdomen feels horrible, my right leg thigh muscle.. very odd. Jaw pain. Burning feet , joint pain , you name it  The anxiety just creeps up into brain fog. I don't think I could explain this to anyone who is unfamiliar.  Also,  I most likely will not remember posting this until I check it.  This is highly unusual for me because I have an excellent memory.  One weekend before I knew anything about celiac I lost an entire weekend from severe brain fog, confusion, pain, etc.  I honestly thought I was losing my mind. When I think back I recall eating a lot of PBJ sandwiches and turkey sandwiches.  Once again did not know about gluten.  I was just too sick to cook. Do people fast during attacks ?? It seems horrible to keep going through this. I hope I'm not causing my own problems... I wonder if I should fast because I'm not eating gluten .  Chicken ,  scrambled eggs no milk , canned carrots,  gluten free low sugar low fat Greek yogurt which I already posted about 😞 Any suggestions I am open... I am bedridden when this happens to me.  Thank you Celiac community. 🙏🏻❤️      
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.