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Can Anyone Understand My Genetic Testing Results?

Beccels

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Beccels Rookie
Beccels
Posted

I was wondering if anyone can make sense of my genetic testings; here it is:

"Heterozygous for the DRB1*07-DQA1*02-DQB1*02 haplotype which is consistent with the DQ2 phenotype"

My blood tests are (although I had already been on the gluten free diet for 1.5 weeks at the time of the test):

Gliadin IgA Abs: 2 (Normal Range 0 - 20)

tTG IgA/IgG: 2 (Normal Range 0 - 20)

I understand that I have?? the DQ2 gene, but does this actually mean anything? The celiac blood test came back negative. Am I gluten sensitive? Is there any way to try?

My possible symptoms are migraine variant (prolonged aura without infraction), super super low magnesium, low iron (although I have never been a big meat eater) and low B12 .. generally vitamins are ok now due to suppliments. Always very sleepy and tired. Although I am over-weight due to abortive migraine medications. And have never noticed 'typical' gastro related problems.

Thanks so much.

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ravenwoodglass Mentor
ravenwoodglass
Posted

You do have one of the main celiac associated genes. As to the negative blood tests there are false negatives. You do sound like you could be one of us. After you are done with all the testing you choose to do then I would give the diet a good strict try.

Beccels Rookie
Beccels
Posted
  • Author

You do have one of the main celiac associated genes. As to the negative blood tests there are false negatives. You do sound like you could be one of us. After you are done with all the testing you choose to do then I would give the diet a good strict try.

Thanks so much for the reply ... I really appricate it.

I have been on a gluten, wheat and dairy free diet for 5 weeks now. I have been in a bad detox for about 3 - 4 weeks, only now just starting to feel semi decent.

What are false negatives?

Where do I go from here??

Sorry. So many questions. We only got these results 1 week ago. It's all totally new to me, but obviously something my Dr considered investigating.

nora-n Rookie
nora-n
Posted

Yes, it does sound like celiac, especially with the vitamin deficiences. Allergies do not cause vitamin deficiences, but villi damage does.

The b-12 supplements might be the thing that caused the negative blood tests, since b-12 is so strong at regenerating tissue that it caused negative blood tests.

The celiac blood tests are only positive when there is extensive tissue damage.

many people then order private tests through Enterolab, and they can pick up ttg and antigliadin antibodies even if you have been gluten free for a while.

DQ2 is the main celiac gene. You do not need any more gene tests, since you are positive. Heterozygous means you have one copy. But enterolab will tell you which other DQ gene there is, because you have two DQ genes.

Beccels Rookie
Beccels
Posted
  • Author

Thanks so much for your reply. Do you think I might be on the right track? If you both tend to think so, I think I might begin to feel a bit positive about the whole thing.

I remembered a full blood count that I had a few years ago.

The total of bloods, that indicate strange counts are as follows:

Magnesium (super super low in urine collection) I take supplements for mag.

Creatinine (pretty low in urine collection)

Calicum - High in blood

Albumin - High in blood

Bicarbonate - Low in blood

My iron has always been low - I take supplements

And B12 has been low - I take supplements.

Sodium and Potassium were each 1 mmol/L within the low range.

Does this tell any story?? Or can most people be like this?

Is there any point in trying to understand the genes I have? Will it give any clearer indication in any way? Or should I just be happy with the limited knowledge I have, yes - there is something there .. and that is that.

I can't find any information that I can actually understand on the internet.

  • 2 weeks later...
Beccels Rookie
Beccels
Posted
  • Author

The b-12 supplements might be the thing that caused the negative blood tests, since b-12 is so strong at regenerating tissue that it caused negative blood tests.

The celiac blood tests are only positive when there is extensive tissue damage.

I was just wondering if there are any articles or study's on the internet about B12 creating a false positive, so I could send it to my Dr?

I can't seem to find anything. I have googled!

nora-n Rookie
nora-n
Posted

These are just speculations I read somewhere, and it does seem logical.....I had negative biopsies and I took B-12 so I wonder too.

Several people have posted that they had negative biopsies from taking steroids, and there are a few articles that corroberate that, but not many.

I doubt there are any references to b-12 and negative biopsies.

maybe Dr. Lewey has some comments, his website is www.thefooddoc.com he seems very open. You can try mailing him.

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Beccels Rookie
Beccels
Posted
  • Author

Hi!

Thanks for that. I tend to agree, it sounds logical in a semi medical non-discript way!

Im going to check out that website now. Thanks!!

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