I Just Got My Entero Lab Results And I Am Not Surprised But A Bit Confused

[Christi1996]

While it is nice to get confirmation that it is not all in my head, I would like to be normal and not worry about the whole gluten-free and now dairy-free too.

What has me completely confused is the gene testing. It says I have 2 copies of the DQB1-0201 and DBQ1-0302 so it that 4 genes (or maybe chromosomes) or 2 and then what is the HLA-DQ 2,3 (subtype 2,8).

I loved the genetics portion of biology but that was 20 years ago and it didn't go into this depth. Is there an Idiots Guide to Gene Testing?

Oh and what is the Anti-tissue Trasglutaminase?

Anyway, here are the actual results:

Fecal Anti-gliadin IgA 37 Units (Normal Range is less than 10 Units)

Fecal Anti-tissue Transglutaminase IgA 10 Units (Normal Range is less than 10 Units)

Quantitative Microscopic Fecal Fat Score 549 Units (Normal Range is less than 300 Units)

Fecal Anti-casein (cow

[MsCurious]

While it is nice to get confirmation that it is not all in my head, I would like to be normal and not worry about the whole gluten-free and now dairy-free too.

What has me completely confused is the gene testing. It says I have 2 copies of the DQB1-0201 and DBQ1-0302 so it that 4 genes (or maybe chromosomes) or 2 and then what is the HLA-DQ 2,3 (subtype 2,8).

I loved the genetics portion of biology but that was 20 years ago and it didn't go into this depth. Is there an Idiots Guide to Gene Testing?

Anyway, here are the actual results:

HLA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 Molecular analysis, Allele 2 0302

Serologic equivalent: HLA-DQ 2,3 (Subtype 2,8)

Interpretation Of HLA-DQ Testing: HLA-DQB1 gene analysis reveals that you have two copies of the main genes that predispose to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HLA-DQB1*0302. Having two copies of a gluten sensitive or celiac gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe

Your question about your genetic testing is similar to one I just responded to yesterday in the "Celiac Disease - Pre-Diagnosis, Testing & Symptoms" forum ...the thread was "So Confused About Test". Rather than retype inserting your genetic info... take a look at that post. Your situation is a little different, in that you received HLA-DQB markers from both of your parents that are in the gene pool of "Celiac" possibility. You receive one HLA-DQA and one HLA-DQB allele (one pair) from each parent. In your case BOTH of the HLA-DQB alleles are the culprits.

From your results I don't know what your HLA-DQA1 markers are but I'll just put x's in so you can see what your two markers from your parents would look like in their entirety.

HLA-DQA1*XXXX/DQB1*0201

HLA-DQA1*XXXX/DQB1*0302

They didn't list your DQA1 alleles because apparently they were NOT Celiac related genes, but both of your DQB alleles are celiac related. As you can see you received half of a pair from each parent that relate to celiac as opposed to someone like me who received one genetic pair related to celiac disease from just ONE parent (HLA-DQA1*0501/DQB1*0201)

If you have more specific questions, send me a message and I'll try to direct you to more helpful info. good luck to you!

[salexander421]

They didn't list your DQA1 alleles because apparently they were NOT Celiac related genes, but both of your DQB alleles are celiac related.

Enterolab does not test for DQA1 alleles.

[Evangeline]

You should also get the soy and yeast test too before they dispose of your stool sample. I believe I read that 60% of Celiacs are soy intolerant? Every Celiac I know cannot eat soy. So you should include that.