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Blood Results: What Does This All Mean?


Weasel007

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Weasel007 Newbie

Hello everyone.

I just got my results back from the lab. I understand everything but the last part. Can someone tell me if this is a preliminary "negative" result, or does it mean something else? I also have Hashimotos, if that explains anything.

Celiac Disease Comprehensive Result Flag Units Reference

Deamidated Gliadin Abs, IgA 7 units 0-19

Deamidated Gliadin Abs, IgC 2 units 0-19

t-Transblutaminase (tTG) IgA <2 U/mL 0-3

Tissue Transglutaminase (tGG) has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy.

t-Transglutaminase (tTG) IgG <2 U/mL 0-5

Endomysial Antibody IgA Negative Negative

Immunoglobulin A, Qn, Serum 315 mg/dL 70-400

Thanks all!!

Therese


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pain*in*my*gut Apprentice

Hello everyone.

I just got my results back from the lab. I understand everything but the last part. Can someone tell me if this is a preliminary "negative" result, or does it mean something else? I also have Hashimotos, if that explains anything.

Celiac Disease Comprehensive Result Flag Units Reference

Deamidated Gliadin Abs, IgA 7 units 0-19

Deamidated Gliadin Abs, IgC 2 units 0-19

t-Transblutaminase (tTG) IgA <2 U/mL 0-3

Tissue Transglutaminase (tGG) has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy.

t-Transglutaminase (tTG) IgG <2 U/mL 0-5

Endomysial Antibody IgA Negative Negative

Immunoglobulin A, Qn, Serum 315 mg/dL 70-400

Thanks all!!

Therese

The last part is the test for the endomysial antibody (a very Celiac specific marker)...you were negative. The second test was for IgA deficiency (immunoglobulin, A, quant). Yours was in the normal range, which just verifies that the other IgA mediated tests are accurate, and not falsely neg due to IgA deficiency.

Hope this helps!

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      Thanks for the reply. 
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      What you’re describing is actually very common, and unfortunately the timing of the biopsy likely explains the confusion. Yes, it is absolutely possible for the small intestine to heal enough in three months on a strict gluten-free diet to produce a normal or near-normal biopsy, especially when damage was mild to begin with. In contrast, celiac antibodies can stay elevated for many months or even years after gluten removal, so persistently high antibody levels alongside the celiac genes and clear nutrient deficiencies strongly point to celiac disease, even if you don’t feel symptoms. Many people with celiac are asymptomatic but still develop iron and vitamin deficiencies and silent intestinal damage. The lack of immediate symptoms makes it harder emotionally, but it doesn’t mean gluten isn’t harming you. Most specialists would consider this a case of celiac disease with a false-negative biopsy due to early healing rather than “something else,” and staying consistently gluten-free is what protects you long-term—even when your body doesn’t protest right away.
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