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alicewa

Type 1 Diabetes - Triggers From Celiac Or Dairy?

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I'm curious about celiac and it's link to other autoimmune diseases. Would a gluten free diet for life reduce the risk of type 1 diabetes? I've heard of people developing T1 diabetes many years before being diagnosed with celiac but I have yet to hear of a case of someone developing T1 diabetes who's already been following a gluten free diet for many years.

The conditions are related, but I don't know if eliminating one reduces risk of the other. Perhaps I should also remove dairy (most doctors tell me to keep it in my diet as I seem to be ok with it so far) but a number of scientists say that BCM7 in the A1 beta casein (the stuff they injected in mice who then developed T1 diabetes) is definitely a culprit.

I try not to worry too much about it but I try and stay aware that many of my immediate family have this condition and that I seem to possess the genes too.

I am a bit anxious and paranoid, but any ideas or advice on what you would do in this situation would be most appreciated. I've been gluten-free since August.

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I have heard that celiac can cause type 1 diabetes. Which has made me wonder if my daughter was diagnosed with celiac before 3 if she would be diabetic. She had shown signs of celiac since she was one and was not diagnosed till she was 4 1/2 but got diagnosed with diabetes at 3. My baby boy still eats gluten sometimes he just turned one and I plan on getting the celiac panel done on him to see how his results are and decide if I will take him off it after that happens next week because I don't want to cause him other problems. I have celiac for years I never knew till a year ago after having my boy but do not have other autoimmune diseases that I know of. But having 1 can make you more at risk for other ones I think.

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There is a correlation between celiac disease and type 1 diabetes, but it is not well understood. If you already have one, you are more likely than the general population to develop the other.

Diabetes, especially type 1, is easy to diagnose, while celiac disease is frequently overlooked or thought to be something else. I developed late onset type 1 in my early thirties. My celiac disease diagnosis was at 46--but I had serious symptoms for several years, and may have had undiagnosed celiac disease going back to my youth.


Peter

Diagnosis by biopsy of practically non-existent villi; gluten-free since July 2000. I was retested five years later and the biopsy was normal. You can beat this disease!

Type 1 (autoimmune) diabetes diagnosed in March 1986

Markham, Ontario (borders on Toronto)

Celiac.com - Celiac Disease Board Moderator since 2007

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The casein research is pretty interesting, isn't it? I'd stick to A2 milk as much as possible if I had a lot of type 1 diabetes in the family, at least until they learn more about diabetes and milk. Unfortunately the holstein-heavy US dairy industry is trying hard to suppress the research. Goat milk dairy is pretty widely available now.

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T1 D is easy to dx but still easily goes undx or mis dx in adults onset cases. I was thin so all the docs said I couldn't possibly have diabetes. Don't worry! they said. Even when I was dx at 77 lbs they called me a T2 because my numbers weren't what they expected for a classic T1. LADA form of diabetes is slow onset and often goes undx or mis dx. It is not well understood or known by many mainstream docs. We here are more likely to present with LADA.

I have celiac disease. I have a casein allergy and I have adult onset T1. Which came first or how do they interact? Who knows? I had a casein allergy since birth but it was not well understood or properly addressed. My mom just didn't give me milk in a glass. Sad but true. After diabetes dx I found that casein raises my BG significantly. I was re-tested to confirm the casein allergy and plan to avoid it for life now. Both my diabetes and celiac disease went undx at least 10 years. I certainly had both since my pregnancy with my only child. I had symptoms of both a good 5 years or more before that.

I work hard to reduce the strain on my immune system now.


Me: GLUTEN-FREE 7/06, multiple food allergies, T2 DIABETES DX 8/08, LADA-Latent Autoimmune Diabetes in Adults, Who knew food allergies could trigger an autoimmune attack on the pancreas?! 1/11 Re-DX T1 DM, pos. DQ2 Celiac gene test 9/11

Son: ADHD '06,

neg. CELIAC PANEL 5/07

ALLERGY: "positive" blood and skin tests to wheat, which triggers his eczema '08

ENTEROLAB testing: elevated Fecal Anti-tissue Transglutaminase IgA Dec. '08

Gluten-free-Feb. '09

other food allergies

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The casein research is pretty interesting, isn't it? I'd stick to A2 milk as much as possible if I had a lot of type 1 diabetes in the family, at least until they learn more about diabetes and milk. Unfortunately the holstein-heavy US dairy industry is trying hard to suppress the research. Goat milk dairy is pretty widely available now.

Is organic milk safe? What about organic butter. These products can be from holstein cattle too, can't they? I drink jersey milk, it agrees with me better. Can't find any A2/jersey butter at all. :(

Also do all holstein cattle have A1 beta casein in them?

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Butter is easy. Make yourself ghee. It tastes just as good, keeps for months, and all the troublesome casein is gone if you're careful about filtering it.

http://reallivefood.wordpress.com/2010/02/08/how-to-make-ghee/

Organic has nothing to do with A1 vs. A2 casein. Individual cows have to be tested for what kind of beta casein they have, but holsteins are the most likely to have A1. Guernseys are safest, or as I mentioned earlier goats and sheep have only A2. Goats milk and goat or sheep cheeses are always safe. I found this link on breeds for you.

http://www.windsordairy.com/articles/a1-and-a2-milk.html

Remember also that you can help leaky gut issues with probiotics.

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Butter is easy. Make yourself ghee. It tastes just as good, keeps for months, and all the troublesome casein is gone if you're careful about filtering it.

http://reallivefood.wordpress.com/2010/02/08/how-to-make-ghee/

Organic has nothing to do with A1 vs. A2 casein. Individual cows have to be tested for what kind of beta casein they have, but holsteins are the most likely to have A1. Guernseys are safest, or as I mentioned earlier goats and sheep have only A2. Goats milk and goat or sheep cheeses are always safe. I found this link on breeds for you.

http://www.windsordairy.com/articles/a1-and-a2-milk.html

Remember also that you can help leaky gut issues with probiotics.

What sort of probiotic would be best for celiacs? The one I have has two different bacteria.

Wouldn't a prebiotic be fairly important?

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The main celiac gene - HLA DQ2 - is also the type I diabetes gene: This includes DQ2.5 like I have. The combination of DQ2 and DQ8 predisposes the holder to LADA (late oneset Type 1). See article: http://en.wikipedia.org/wiki/HLA-DQ2

So, yes, there is a connection, especially for DQ2 holders.

I have DQ 2 and my maternal grandfather had Type I late onset (he was 40 when diagnosed). He was on insulin and was skinny as a rail - 100 pounds and 5'6" and had stomach problems all his life. (Irish/German ancestry)

Missy's Mom: Have you had your genes tested?


Diagnosed by biopsy 2/12/07. Negative blood tests. Gluten-free (except for accidents) since 2/15/07. DQ2.5 (HLA DQA1*05:DQB1*0201)

Son, age 18, previously delayed growth 3rd percentile weight, 25th percentile height (5'3" at age 15). Negative blood work. Endoscopy declined. Enterolab positive 3/12/08. Gene results: HLA-DQB1 Molecular analysis, Allele 1 0201 HLA-DQB1 Molecular analysis, Allele 2 0503 Serologic equivalent: HLA-DQ 2,1(Subtype 2,5) Went gluten-free, casein-free 3/15/08. Now 6'2" (Over six feet!) and doing great.

"Great difficulties may be surmounted by patience and perseverance." Abigail Adams (1744-1818) 2nd First Lady of the United States

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The main celiac gene - HLA DQ2 - is also the type I diabetes gene: This includes DQ2.5 like I have. The combination of DQ2 and DQ8 predisposes the holder to LADA (late oneset Type 1). See article: http://en.wikipedia.org/wiki/HLA-DQ2

So, yes, there is a connection, especially for DQ2 holders.

I have DQ 2 and my maternal grandfather had Type I late onset (he was 40 when diagnosed). He was on insulin and was skinny as a rail - 100 pounds and 5'6" and had stomach problems all his life. (Irish/German ancestry)

Missy's Mom: Have you had your genes tested?

Oh, I'm the poster child for this ;) Yes, a few months ago I was gene tested and have DQ2. The Labcorp test didn't break down the genes into much detail but theres the DQ2. You and I understand the connections but the docs have no understanding of all this.

My maternal grandmother's family immigrated to the U.S from Ireland for what it's worth. No many generations ago.


Me: GLUTEN-FREE 7/06, multiple food allergies, T2 DIABETES DX 8/08, LADA-Latent Autoimmune Diabetes in Adults, Who knew food allergies could trigger an autoimmune attack on the pancreas?! 1/11 Re-DX T1 DM, pos. DQ2 Celiac gene test 9/11

Son: ADHD '06,

neg. CELIAC PANEL 5/07

ALLERGY: "positive" blood and skin tests to wheat, which triggers his eczema '08

ENTEROLAB testing: elevated Fecal Anti-tissue Transglutaminase IgA Dec. '08

Gluten-free-Feb. '09

other food allergies

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Alicewa, I was tolerating goat casein after avoiding all casein for a year. I introduced goat, tolerated it well, got tested and my skin test for goat was negative and all was good but after a year of moderate consumption of goat, my casein allergy crossed over to goat and I am now allergic. :( I miss it.


Me: GLUTEN-FREE 7/06, multiple food allergies, T2 DIABETES DX 8/08, LADA-Latent Autoimmune Diabetes in Adults, Who knew food allergies could trigger an autoimmune attack on the pancreas?! 1/11 Re-DX T1 DM, pos. DQ2 Celiac gene test 9/11

Son: ADHD '06,

neg. CELIAC PANEL 5/07

ALLERGY: "positive" blood and skin tests to wheat, which triggers his eczema '08

ENTEROLAB testing: elevated Fecal Anti-tissue Transglutaminase IgA Dec. '08

Gluten-free-Feb. '09

other food allergies

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AT-1001, the zonulin inhibitor, is also about stopping the autoimmune attack on the pancreas

http://www.albatherapeutics.com/

you can also google zonulin diabetes


gluten-free since may 06 after neg. biopsy symptoms went away and DH symptoms which I had since 03 got gradually better.

daughter officially diagnosed celiac and casein intolerant.

non-DQ2 or DQ8. Maybe DQ1? Updated: Yes, double DQ5

Hypothyroid since 2000, thyroxine first started to work well 06 on a low-carb and gluten-free diet

Lost 20 kg after going gluten-free and weighing 53 kg now. neg. biopsy for DH. Found out afterwards from this forum that it should have been taken during an outbreak but it was taken two weeks after. vitaminD was 57 nmol/l in may08)

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What sort of probiotic would be best for celiacs? The one I have has two different bacteria.

Wouldn't a prebiotic be fairly important?

Two strains isn't enough. In the GAPS book Campbell-McBride says:

1) As many species as possible.

2) A mixture of strains from different groups. A combination of representatives from the three main groups, Lactobacilli, Bifidobacteria, and soil bacteria (often Bacillus) usually works best.

3) At least 8 billion cells per gram; she considers therapeutic levels for adults to be 15-20 billion cells/day for six months, then a maintenance dose that is often around half the therapeutic dose.

4) Every batch should be tested and the manufacturer should be willing to publish the testing.

Prebiotics is an interesting question. Fructo-oligosaccharides and inulin are not allowed on GAPS/SCD because they cause so many problems for people with stomach trouble. On the flip side, herbs like dandelion and burdock have a long-established role for stomach trouble in traditional medicine. You would have to try the prebiotics and see how you feel. :)

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I've heard about zonulin and the problems it can cause. Would there be any side affects to inhibiting its production though?

Heaven only knows. New drugs have all sorts of unpleasant, unintended side effects they don't figure out until after it's on the market and tens of thousands of people have taken it.

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this is the pill that all the celiac forums have been talking about for several years, Fasano


gluten-free since may 06 after neg. biopsy symptoms went away and DH symptoms which I had since 03 got gradually better.

daughter officially diagnosed celiac and casein intolerant.

non-DQ2 or DQ8. Maybe DQ1? Updated: Yes, double DQ5

Hypothyroid since 2000, thyroxine first started to work well 06 on a low-carb and gluten-free diet

Lost 20 kg after going gluten-free and weighing 53 kg now. neg. biopsy for DH. Found out afterwards from this forum that it should have been taken during an outbreak but it was taken two weeks after. vitaminD was 57 nmol/l in may08)

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