Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Update And More Questions On Testing - Igg Deficient?

beachbirdie

Recommended Posts

beachbirdie Contributor
beachbirdie
Posted

I originally posted a request for help HERE and thought I should start a new topic since so much time has passed.

I finally received a packet with my mom's lab work. At first glance, I would assume mom is NOT celiac as she tested negative for all the celiac antibodies.

However, and this is puzzling, mom had these curious numbers:

Immunoglobulin A, QN, Serum: 54 (range 70-400)

Immunoglobulin G, QN, Serum: 480 (range 700-1600)

Immunoglobulin M, QN, Serum: 116 (range 40-230)

Now that I see mom deficient in both IgA and IgG, my question is whether I can rely on ANY of the celiac tests, since they test only those components.

Does a low IgG create the same accuracy issues as a low IgA does?

I'm a little angry that the doc said he would do the genes, and then didn't. However, I'm guessing it is a rare gift to have found the low IgG, I doubt most docs would have done that test.

Thanks ever so much for any insight you can give me!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Skylark Collaborator
Skylark
Posted

Yes, low IgG would create the same accuracy issues. If you have half the total antibodies, a test will have half the total signal in the ELISA. Cutting the signal in half could make a low positive into a negative pretty easily.

beachbirdie Contributor
beachbirdie
Posted
  • Author

Yes, low IgG would create the same accuracy issues. If you have half the total antibodies, a test will have half the total signal in the ELISA. Cutting the signal in half could make a low positive into a negative pretty easily.

Thank you very much! I have a whole new "rabbit hole" to dive into now. I've discovered the need to differentiate between Common Variable Immunodeficiency versus issues created by what the hematologist calls "smoldering" multiple myeloma; now trying to sort out a whole new world of information.

I was thinking these tests would put everything in a perfect perspective, turns out my mom's body is doing things that happen only to 1/1000 and 1/100,000 and we need to keep researching. I should have her buy me a lottery ticket or two. :ph34r:

Skylark Collaborator
Skylark
Posted

Wow, that's a TON of reading to do. It sometimes seems like we have to turn ourselves into doctors, which is a little frustrating. I hope you make great progress with your mom!

IrishHeart Veteran
IrishHeart
Posted

I see Skylark has answered you :) and... Yes, I did see your original post which refreshed my memory. :)

Your Mom and My Dad and Me--are those people who hear "well, that is unusual, happens about 1-2% of the time or 16% of patients...or my fav "in my 35 years, I have NEVER seen a patient who presents with your"....blah blah ...." (gee thanks, doc that makes me feel encouraged :rolleyes: )

And to echo Sylark, yes, we have to be our own best advocates and sometimes, our parents' advocates. Bless you for being so good to your Mom! :)

Regarding multiple myeloma...where do I start?. A friend of ours was Dxed with this years ago (long before I knew I had celiac) and when I found it could be related to gluten intolerance, I could have cried. If only I knew back then what I know now...

anyway, here are some things I found while researching MM.

https://www.celiac.com/articles/21542/1/Celiac-Disease-and-Paraproteinemia-Serum-Monoclonal-Proteins/Page1.html

https://www.celiac.com/articles/21836/1/Patients-with-Celiac-Disease-Multiple-Myeloma-React-Differently-to-Various-Kinds-of-Gliadin/Page1.html

Open Original Shared Link

Open Original Shared Link

Open Original Shared Link

Open Original Shared Link

I trust she is still on a gluten-free diet??? :)

Takala Enthusiast
Takala
Posted

Yes, low IgG would create the same accuracy issues. If you have half the total antibodies, a test will have half the total signal in the ELISA. Cutting the signal in half could make a low positive into a negative pretty easily.

I nominate this for the best answer to any question this week, succinct, but easy to understand !

beachbirdie Contributor
beachbirdie
Posted
  • Author

I see Skylark has answered you :) and... Yes, I did see your original post which refreshed my memory. :)

Your Mom and My Dad and Me--are those people who hear "well, that is unusual, happens about 1-2% of the time or 16% of patients...or my fav "in my 35 years, I have NEVER seen a patient who presents with your"....blah blah ...." (gee thanks, doc that makes me feel encouraged :rolleyes: )

I trust she is still on a gluten-free diet??? :)

Wow, thanks for all the links, IrishHeart! Got my work cut out for me! :wacko: I was aware that there could be a connection which is why I braved asking the hematologist for more tests...I knew he would not likely balk as badly as the general practitioner, neurologist, chiropractor, and osteopath did. I will get to reading. :ph34r:

Sadly, mom has not yet begun her gluten-free diet. We needed to keep her glutened until we got the bloodwork done satisfactorily. Also, we are 600 miles away and at this point we would not be able to manage the switch. We will be with her in just a few days now and start her on GAPS/SCD if she doesn't balk too hard. We are praying it helps. Thanks again, very much! :)

I nominate this for the best answer to any question this week, succinct, but easy to understand !

LOL, Takala! That's what I thought too! :D

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Skylark Collaborator
Skylark
Posted

LOL, Takala! That's what I thought too! :D

Thanks for the kind words. I must have had a rare non-brain-fogged moment in there. :lol:

beachbirdie Contributor
beachbirdie
Posted
  • Author

Thanks for the kind words. I must have had a rare non-brain-fogged moment in there. :lol:

:lol: It seemed like kind of a dumb question for me to ask, but I thought (in my own foggy brain) I might be missing something!

I appreciate you taking the time for even an obvious question!

Skylark Collaborator
Skylark
Posted

It's not obvious at all. I understand it because I have run ELISA assays, plus I read a paper on how even low-normal IgA can make TTG testing unreliable. I like to help, like everyone around here, and I actually knew the answer to that one. :lol:

IrishHeart Veteran
IrishHeart
Posted

I nominate this for the best answer to any question this week, succinct, but easy to understand !

:)

ditto

yaayy Skylark!

:lol:

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,017
    • Most Online (within 30 mins)
      7,748
    Sjcucinotta
    Newest Member
    Sjcucinotta
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • sleuth
      Nicotine Gum For Gluten Symptoms.. Am I Crazy?

      By sleuth · Posted

      He is not just a psychiatrist.  He is also a neuroscientist.  And yes, I have already read those studies.   I agree with benfotiamine.  This is short term while glutened/inflammation occurs.  As I had already mentioned, these symptoms no longer exist when this phase passes.  And yes, I know that celiac is a disease of malnutrition.  We are working with a naturopath.
    • knitty kitty
      Nicotine Gum For Gluten Symptoms.. Am I Crazy?

      By knitty kitty · Posted

      Please do more research before you settle on nicotine. Dr. Paul New house is a psychiatrist.  His latest study involves the effect of nicotine patches on Late Life Depression which has reached no long term conclusions about the benefits.   Effects of open-label transdermal nicotine antidepressant augmentation on affective symptoms and executive function in late-life depression https://pubmed.ncbi.nlm.nih.gov/39009312/   I'm approaching the subject from the Microbiologist's point of view which shows nicotine blocks Thiamine B1 uptake and usage:   Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells https://pubmed.ncbi.nlm.nih.gov/26633299/   While supplementation with thiamine in the form Benfotiamine can protect from damage done by  nicotine: Benfotiamine attenuates nicotine and uric acid-induced vascular endothelial dysfunction in the rat https://pubmed.ncbi.nlm.nih.gov/18951979/   I suggest you study the beneficial effects of Thiamine (Benfotiamine and TTFD) on the body and mental health done by Dr. Derrick Lonsdale and Dr. Chandler Marrs.  Dr. Lonsdale had studied thiamine over fifty years.   Hiding in Plain Sight: Modern Thiamine Deficiency https://pmc.ncbi.nlm.nih.gov/articles/PMC8533683/ I suggest you read their book Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition.     Celiac Disease is a disease of malabsorption causing malnutrition.  Thiamine and benfotiamine: Focus on their therapeutic potential https://pmc.ncbi.nlm.nih.gov/articles/PMC10682628/
    • sleuth
      Nicotine Gum For Gluten Symptoms.. Am I Crazy?

      By sleuth · Posted

      Thanks for your response.  Everything you mentioned he is and has been doing.  Tobacco is not the same as nicotine.  Nicotine, in the form of a patch, does not cause gastrointestinal irritation.  Smoking does. He is not smoking.  Please do your research before stating false information. Dr. Paul Newhouse has been doing research on nicotine the last 40 years at Vanderbilt University Medical Center.  
    • Jmartes71
      Fighting for a name

      By Jmartes71 · Posted

      Im so frustrated and still getting the run around trying to reprove my celiac disease which my past primary ignored for 25 years.I understand that theres a ray of medical that doctors are limited too but not listening and telling the patient ( me) that im not as sensitive as I think and NOT celiac!Correction Mr white coat its not what I think but for cause and affect and past test that are not sticking in my medical records.I get sick violently with foods consumed, not eating the foods will show Im fabulous. After many blood draws and going through doctors I have the HLA- DQ2 positive which I read in a study that Iran conducted that the severity in celiac is in that gene.Im glutenfree and dealing with related issues which core issue of celiac isn't addressed. My skin, right eye, left leg diagestive issues affected. I have high blood pressure because im in pain.Im waisting my time on trying to reprove that Im celiac which is not a disease I want, but unfortunately have.It  has taken over my life personally and professionally. How do I stop getting medically gaslight and get the help needed to bounce back if I ever do bounce back to normal? I thought I was in good care with " celiac specialist " but in her eyes Im good.Im NOT.Sibo positive, IBS, Chronic Fatigue just to name a few and its all related to what I like to call a ghost disease ( celiac) since doctors don't seem to take it seriously. 
    • trents
      Celiac getting dentures

      By trents · Posted

      @Martha Mitchell, your reaction to the lens implant with gluten sounds like it could be an allergic reaction rather than a celiac reaction. It is possible for a celiac to be also allergic to gluten as it is a protein component in wheat, barley and rye.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.