Anyone Dq2.5/dq2.5 Or De2.5/dq2.2 ?

[PersianCeliac]

Hi everyone,

my mother 48 years old was diagnosed with celiac recently she had biposy which showed marsh 3B and gene test which showed she has DQ2.5 and DQ2.2 which from what i have read means she is at higher risk for refractory celiac Aand lymphoma according to one study !!

She has gone gluten free and i am trying to encourage her as much as i can, does anyone here have double copies of DQ2.5 or DQ2.5 with DQ2.2 ? And if so, then did you respond to GFD and how long did it take you to recover ?

my mother didnt have symptoms prior to diagnosis so it is hard to tell if she is respoing. I am just worried for her.

[cyberprof]

Hi everyone,

my mother 48 years old was diagnosed with celiac recently she had biposy which showed marsh 3B and gene test which showed she has DQ2.5 and DQ2.2 which from what i have read means she is at higher risk for refractory celiac Aand lymphoma according to one study !!

She has gone gluten free and i am trying to encourage her as much as i can, does anyone here have double copies of DQ2.5 or DQ2.5 with DQ2.2 ? And if so, then did you respond to GFD and how long did it take you to recover ?

my mother didnt have symptoms prior to diagnosis so it is hard to tell if she is respoing. I am just worried for her.

Hi PersianCeliac, and welcome.

I hope you (and your mom) can not worry too much. The risk of refractory celiac is low and she's on the right track, so try not to worry. The best thing to do is to eat naturally gluten-free whole foods - meats, veggies, fruits, rice, potatoes - and limit eating out to start with, and then see how she does. Is the doctor going to re-test her blood/biopsy in 6-12 months?

As far as I know, I only have one DQ copy, so I can't help you there.

Do you have a link to the study?

[PersianCeliac]

Hi PersianCeliac, and welcome.

I hope you (and your mom) can not worry too much. The risk of refractory celiac is low and she's on the right track, so try not to worry. The best thing to do is to eat naturally gluten-free whole foods - meats, veggies, fruits, rice, potatoes - and limit eating out to start with, and then see how she does. Is the doctor going to re-test her blood/biopsy in 6-12 months?

As far as I know, I only have one DQ copy, so I can't help you there.

Do you have a link to the study?

Thank you for your response. Well doctor didn't day after how long she should be re-tested, but from what I have read I guess 1 year would be reasonable given the damage that has been caused and her off the charts blood results ttg >800 !

The link to the study is : Open Original Shared Link

[dilettantesteph]

A celiac researcher told me in a private e-mail that double DQ2.5 genes are associated with super sensitivity.