Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Gene Testing?
0

6 posts in this topic

I've suspected my daughter and myself both have celiacs or at least sensitivity to wheat. My GP ordered a gene test for myself and it apparently came back negative.

I'm a little confused if gene testing is the same as antibody testing? Also, is a gene test impacted by being gluten free at the time of testing?

I have many symptoms of celiacs, as does my daughter, and we've found that these symptoms abate with a strict gluten free diet. I'm unsure if we should try to find out if we do indeed have it again or if the gene test is a failsafe method of diagnosis, regardless of gluten in the diet.

Thank you kindly

0

Share this post


Link to post
Share on other sites


Ads by Google:

Welcome!

Genetic testing is not the same as antibody testing.

The gene test looks for markers that are associated with celiac disease. Two are typically checked for--DQ2 and DQ8--although there is growing evidence that others may be associated. Many people carry the genes without ever developing celiac disease. Your genes are your genes and your diet will not affect testing them.

Doctors in Europe are increasingly recognizing that there are cases of celiac disease, confirmed by positive biopsy, in patients who do not have either DQ2 or DQ8.

Regardless, if your symptoms abate on gluten-free diet, you know what you need to do to be well.

0

Share this post


Link to post
Share on other sites

Thank you for your response. I was just reading about the NCGI and if not Celiacs, my daughter and I have that, for sure. I have so many symptoms of celiacs starting from a young child and during a gluten challenge I ended up in hospital with such severe pain, twice.

I am wondering, does celiac do anything to your bowel? I was having horrible symptoms when going to the toilet and the GP ordered an endoscopy (years ago) to find a possible cause. Nothing was found other than a lot fo pain during it - which they blamed Endometriosis on the outside of the bowel.

What is the consensus here about traces of gluten for somebody with NCGI? Can a Celiac consume something containing a wheat derivative that claims to be gluten free?

Thanks again. I might ask the GP what gene he tested for. I'm in Australia so I'd imagine it is a standard test most Aussie Drs do.

0

Share this post


Link to post
Share on other sites

Sorry to hear your genetic test was not definative. It sounds like your diet trial was overwhelmingly positive, though. Antibody tests would false negative, if you are not eating gluten. What do you need to prove to yourself and others that a gluten free diet is right for you?

Well, I wish you well in your discoveries.

Diana

0

Share this post


Link to post
Share on other sites

Thank you for your comments. I don't need to prove anything about this way of eating but I find it difficult to be so demanding about my daughter's diet without being able to say definitively that she is Celiac. I have other children with allergies and it's easier to discuss with the full knowledge there but in this case, I worry that people just perceive me as being over the top given the other child's extreme allergies.

My daughter has been suffering ulcers in her mouth and headaches again so I was starting to question how good we've been with keeping gluten out of her diet versus just assuming it's viral and not related.

Also, my youngest daughter is now 3 and has just started getting dark bags under her eyes and on/off again tummy aches and runs. She's not shown other signs of allergy per se, other than a vague hives reaction to something we can't yet pin-point. She does have mild asthma though so it's likely she has something wrong in that department. I'm just wondering if we should be keeping her gluten free also. She only eats it infrequently, which is why I was wondering if it was the cause of her troubles.

0

Share this post


Link to post
Share on other sites




I just wanted to update and it turns out both our bloods were for antibodies so therefore are virtually useless, given we were gluten free.

The GP offered to do me another test, with a challenge and even the gene testing if I desired.  He explained exactly what you all did, about how that's not really a guarantee either way and that ultimately it could still turn out to be gluten intolerance which requires the same abstinence.  

He's got my history of bowel and autoimmune etc, troubles and he feels that quite strongly I either have Celiac Disease or the Gluten intolerances and that the testing is really not required if I find a gluten free diet helps.  I felt so reassured by his comments that he's quite up to date with a lot in the Celiac world.

I spoke about the other children and he believes we should just maintain our gluten free status.  I think our third might need to be strictly gluten free if she keeps displaying symptoms although it may prove more difficult as she's quite the food monster.  :)  

Thank you again.  I feel quite resolved about things now and I'm just going to explain to people that we are Gluten Intolerant/suspected Celiacs.  I have found it difficult to justify why we make things difficult with our diet without a distinct diagnosis and now I don't, so thank you all for that.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,345
    • Total Posts
      920,489
  • Topics

  • Posts

    • I am sorry that you are sick!   Unfortunately, all celiac testing requires you to be on gluten.  😔.   Testing is usually not over until you get an actual diagnosis, but it appears that you may very well have celiac disease.    Here is more information: http://www.cureceliacdisease.org/screening/ http://theceliacmd.com/2015/06/six-reasons-to-test-for-celiac-disease-before-starting-a-gluten-free-diet-3/ in the meantime, you can eliminate dairy products temporarily.  It may provide some relief.  
    • Karen, the iodine test was a test for DH used in the 'olden' days. Iodine would be swabbed onto a spot and then it would be covered with a bandage. If someone had DH the iodined area would break out in lesions. I don't know how but we do know iodine can activate the antibodies. That is why some of us with DH have to avoid iodine in foods until the antibodies have cleared the dermis. OP, if you haven't been tested for celiac you should be and if you have active lesions a biopsy done next to a lesion by a DH knowledgable dermatologist may help in diagnosis.
    • The gluten-free diet (GFD) is the only validated treatment for celiac disease (celiac disease), but despite strict adherence, complete mucosal recovery is rarely ... View the full article
    • What's an " iodine test"?  Haven't heard doctors doing that to diagnose DH.
    • Hello! I've just been given my blood results and told they are highly suggestive of coeliacs but will have to wait till next month to see the gastroenterologist and who knows how much longer for a biopsy. My igA, igG and tissuetrans igA were all over 250 and tissuetrans igG was the only one that was normal. These results don't mean much to me yet but I'm told they are very high. I'm now quite fearful of how much damage I've gone to myself. I've had stomach problems for 25 years (just turned 40) and have often steered clear of too much bread and pasta for how bloated it made me feel but the symptoms were always vague and inconsistent so I kept eating. I had a couple of boats of gastro in the past few months (thanks kids) which I took a lot longer than normal to recover from which looking back may have been related. Then last Friday I had a blowout with wine, cheese, crackers, pizza and chocolate cake. I'm sure I've probably had blowouts like that before but I have never felt so sick before and am still slowly recovering. This is what finally prompted me to go back to my GP after being fobbed off so many times over the years. So I guess my question and my concern is whether there is still  chance of a false positive with levels like this? I worry what else it might be if not coeliac. I'm also worried that I may have done so much damage to myself that I will have several disorders going on! I'm also still recovering from last Friday and wondering when I'm going to feel better. I've stayed off gluten and dairy since my blood result a couple of days ago but feel like I'm allergic to food in general.  Thankyou!!    
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

    There are no registered users currently online

  • Member Statistics

    • Total Members
      61,415
    • Most Online
      1,763

    Newest Member
    Ails123
    Joined