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ActoGeniX Is Progressing Toward Celiac Disease Treatment

Celiac.com 04/20/2008 - ActoGeniX is a recently formed Belgian company specializing in the development and use of genetically altered probiotic Lactococcus lactis bacteria designed to secrete and deliver therapeutic peptides and proteins to treat gastrointestinal disorders. Their product is called ActoBiotics™. Celiac disease is among the disorders ActoGeniX is currently investigating. Research has already shown efficacy in a celiac disease model where ActoBiotics™ continuously secrete small segments of gluten peptides to induce tolerance to gluten. Further research and trials are in the pipeline.

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Shortly after the release of a recent paper by Italian researchers demonstrating that a peptide from durum wheat is able to completely suppress the immune response to gluten in a culture of celiac disease intestinal T cells (see Durum Wheat Peptide Could Lead To Celiac Disease Treatment ), I contacted ActoGeniX to suggest they work with the Italian researchers to create an ActoBiotic™ designed to continuously secrete the durum wheat peptide as a therapy for celiac disease. ActoGeniX replied and was very interested in the durum wheat peptide, indicating it was possible for them to produce an ActoBiotic™ to secrete the durum wheat peptide and they would contact the Italian group. I also attempted to contact the Italian researchers to inform them about ActoGeniX, but they did not reply. I strongly believe that a collaboration between these two groups would result in the speediest and most successful development of a treatment which could effectively "cure" celiac disease through continuous secretion of the durum wheat peptide by genetically modified probiotic bacteria in the gut.

ActoGeniX has recently totally revised their website which is now much more informative and includes short videos discussing ActoBiotics™ as well as a short video presentation of their celiac disease research. More about this article can be found on their website at http://www.actogenix.com/eng/products/celiacdisease.php.

Technical information describing their product and initial research and development in detail is presented in the following patent application:  http://www.freepatentsonline.com/WO2007063075.html.

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2 Responses:

 
Ricardo Ferreira
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
01 May 2008 3:05:50 PM PDT
Let´s hope a treatment is available in a near future. :)

 
L.A. Sal
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
13 May 2008 12:42:26 PM PDT
I sure hope there is a cure in the near future, but there's one thing that doesn't make sense:
I have read before about the benefits of probiotics for those of us with celiac, but the use of durum wheat of all things? That is difficult to get my head around, given that we can't have regular pasta, can't even have regular pasta touch gluten-free pasta.




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Might want to look into a keto diet, I have UC on top of celiacs and keto is working great Yeah I have major nerve and brain issues with gluten, gluten ataxia with nerve issues and brain issues. Seems to cause my body to attack my brain and nerve system. My brain stumbles fogs, and starts looping, the confusion causes me to become really irritable, I call it going Mr Hyde. Like my mind will start looping constantly on thoughts and not move driving me literally mad, or it used to. Now days it is primary the numbness anger but the gut issues and sometimes random motor loss limit me motionless to the floor now days for the duration of the major anger effects. Used to be a lot more mental then painful gut. I did a mental trauma post on it on while back where I came out about all my mental issues with gluten.

^^^^^^ good info, tips and tricks^^^^^^^^^ yes, crumbs will make you sick. also, breathing flour/pancake mix, etc that is in the air because eventually, you're going to swallow some.

Hello I was diagnosed Dec 15 of last year and went totally gluten-free the next day. I actually got worse before I got better - it's a steep learning curve - but now, 4 1/2 months later I'm finally seeing improvement. Hang in there.

Called my GI doctor today to make sure he is going to look at my small intestine and do biopsy for Celiac for my EGD and he is. Thanks for the tip everyone about have to start eating gluten again. The office told me to break my gluten free diet and start eating gluten everyday until my EGD. Here's to being miserable again for a few weeks ???

I can completely relate! The horrible mental effects that I have been living with for years is the absolute worst side effect of eating gluten, HANDS DOWN. Worse than the endless tummy aches, worse than the constant diarrhea, worse than the week long migraines, worse than the daily fatigue and body pain.... I honestly though there was something seriously wrong with me and hated my life because of how I felt mentally. I always felt like I was drowning, not in control of my thoughts, trapped in some unexplained misery. My head was always so cloudy, and I was mad because I always felt so slow and stupid. I would feel so lethargic and sad and empty while at the same time be raging inside, wanting to rip out of my own skin. I was mean, terrible, would snap at the people closest to me for no good reason and just felt like I hated everyone and everything. Think of how crappy you feel when you have a terrible cold and flu - I felt that crappy, but mentally. Some days were really bad, some were mild. I always thought it was because I was getting a migraine, or because I had a migraine, or because I had just overcome a migraine, because I didn't sleep well, because....always a random reason to justify why we have all these weird unrelated symptoms before we get diagnosed. I'm happy to say that I have been gluten-free for about 2 months now and though I am not symptom free, the first thing that improved was my mood. I no longer feel foggy and miserable. For the first time in years, my head is clear, I can actually think, and I feel positive and like I am in control of what's going on in my head. I don't hate the world. I don't spend every day bawled up on the corner of the couch depressed and angry. The release of these horrible symptoms is enough to never make me want to cheat, no matter what I have to miss out on. So insane how a little minuscule amount of a stupid protein can wreck such havoc.