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B Vitamins Beneficial for Celiacs on Gluten-Free Diet

Celiac.com 04/15/2009 - A recent clinical study has shown B vitamins to be beneficial for celiac sufferers following gluten-free diets. Vitamin deficiency and less than optimal health are common problems for people with celiac disease, even those who faithfully follow a gluten-free diet. Common problems associated with long-term celiac disease include general malaise, and less than optimal well-being.

To better understand the benefits of supplemental doses of B vitamins for patients with celia disease, a team of researchers recently set out to evaluate the biochemical and clinical effects of B vitamin supplements in adults with long-term celiac disease. The research was made up of doctors C. Hallert, M. Svensson, J. Tholstrup, and B. Hultberg.

The team assembled a group of 65 adults with celiac disease for a double-blind placebo-controlled clinical trial. 61% of the group was female, and each had followed a gluten-free diet for several years.

For 6 months, patients received daily doses of either a placebo, or of B vitamins in the amount of 0.8 mg folic acid, 0.5 mg cyanocobalamin and 3 mg pyridoxine. At the end of the trial period, doctors gauged vitamin effectiveness by measuring psychological general well-being (PGWB), together with total levels of plasma total homocysteine (tHcy), a reliable indicator of B vitamin status.

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In all, 57 of the 61 enrolled patients completed the trial (88%). Baseline tHcy levels for these patients averaged 11.7 micromoles/L (range = 7.4 to 23.0), which was markedly higher than the 10.2 micromoles/L for the control group (range = 6.7 to 22.6) (P < 0.01).

After the B vitamin treatment, patient tHcy levels dropped an average of 34% (P < 0.001). Patients experienced substantial improvement in well-being (P < 0.01). Even patients who initially reported poor well-being showed notable improvements in Anxiety (P < 0.05) and Depressed Mood (P < 0.05) .

These improvements, the normalization of tHcy levels, together with the substantial increase in well-being, led the research team to conclude that people living gluten-free with long-term celiac disease do indeed benefit from daily supplemental doses of vitamin B, and that doctors should consider advising the use of B vitamins supplements for these patients.


Aliment Pharmacol Ther. 2009 Apr 15;29(8):811-6.

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4 Responses:

 
Janice Duncan
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said this on
03 May 2009 5:48:20 AM PDT
Hair loss. That sure got my attention, not my less than optimum health issues. When you start getting handfuls of hair a bell goes off. I have tripled my B complex and really watch my diet.

 
Laura
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said this on
03 May 2009 8:43:09 PM PDT
Thank you so much for your article.

 
Stephanie
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said this on
30 Sep 2009 6:32:01 AM PDT
Great info. I will purchase vitamin B.

 
John
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said this on
24 Oct 2011 5:16:43 AM PDT
It is clear just going gluten free is only part of the road to better health. Magnesium and B vitamins supplements are essential.




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http://www.cghjournal.org/article/S1542-3565(16)30547-X/pdf

This is all so interesting. Thank you all for responding, you've helped me.

You could try removing all grain and dairy and see if that helps. Processed foods can have cross contamination. Lactose intolerance is common with celiac disease. Fruits are high in fructose and it can be difficult for some people to digest fructose if they have digestive problems. Vegetables a...

Yeah with the chocolate, I can attest that it really helps with ones mood, problem is most cocoa is processed and defatted, your best best are RAW cocoa from BigTree, Cocoa Nibs, or my personal favorite Crio Bru which is ground cocoa nibs that are meant as a coffee replacement >.> I eat them by t...

I don't know for sure but if you have a emotional roller coaster it may be do to food sensitivities. The pattern however may be difficult to figure out. I also removed all grains and milk from my diet. I limit my fruit and fructose consumption (fructose binds with tryptophan in the gut) and don...