No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Can a Gluten-free Diet Lower the Risk of Diabetes?

Celiac.com 07/14/2014 - Early life intestinal problems have previously been shown to influence diabetes rates. There is also some evidence that a gluten-free diet can lower rates of diabetes, but just how strong is the influence of gluten-free diet on the development of diabetes?

Image: Wikimedia CommonsA recent study by a group of researchers in Denmark suggests that maternal gluten-free diet greatly reduces inflammation and rates of diabetes in the offspring of certain mice. This study led the team to hypothesize that a gluten-free diet, which is known to decrease type 1 diabetes incidence, may also offer protection against diabetes when followed during the pregnancy and lactation period.

The research team included Camilla H.F. Hansen, Łukasz Krych, Karsten Buschard, Stine B. Metzdorff, Christine Nellemann, Lars H. Hansen, Dennis S. Nielsen, Hanne Frøkiær, Søren Skov and Axel K. Hansen. They are variously affiliated with the Department of Veterinary Disease Biology of the Faculty of Health and Medical Sciences at the University of Copenhagen, the Department of Food Science, Faculty of Science, University of Copenhagen, the Department of Biology, Faculty of Science, University of Copenhagen, the Division of Toxicology and Risk Assessment of the National Food Institute at the Technical University of Denmark in Søborg, Denmark, and the Bartholin Institute in Copenhagen, Denmark.

For their study, the team fed pregnant non-obese diabetic (NOD) mice either a gluten-free diet, or a standard diet, until all pups were weaned to standard diet. Overall, mice which experienced early life gluten-free diets had dramatically lower rates of diabetes and insulitis.

Ads by Google:

An analysis of gut microbiota using 16S rRNA gene sequencing showed a major difference between both mothers and their offspring, marked by higher levels of Akkermansia, Proteobacteria, and TM7 in the gluten-free diet group. Gluten-free fed offspring showed increased M2 macrophage gene markers and tight junction-related genes in the gut, along with higher levels of pancreatic FoxP3 regulatory T cells.

Gluten-free offspring also had reduced intestinal gene expression of proinflammatory cytokines. Finding more T cells in the pancreas expressing the mucosal integrin α4β7 suggests that this is due to an increase in gut-primed immune cells moving to the pancreas.

The study shows clearly that a gluten-free diet during the fetal and early postnatal life lowers rates of diabetes. This may be due to a change in gut microbiota and a reduction in pro-inflammatory conditions in the gut and pancreas.

Clearly, further study is needed to better understand the factors at play, and how they relate to diabetes reduction efforts.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












2 Responses:

 
Mary Thorpe
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
22 Jul 2014 7:32:23 AM PDT
It is not stated which type of diabetes is reduced: 1 or 2. Type 1, I presume?...Just went to the article through the citation given and indeed it's type 1 diabetes that the GF diet protects against.

 
Jefferson
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
04 Aug 2014 12:40:43 PM PDT
Thanks for your comment! Type 1 diabetes is correct. I will adjust the article to make that more clear.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I totally understand. Ive noticed the same thing when I started really ramping up my fitness program. To start, cut out the 30 day challenges. If your serious about fitness, you will incorporate it as a normal entity of life. We already have compromised immune systems so...

Yes^, usually if you tell them about celiac, they know. Almost all nurses know what celiac is. If not, tell them what you can and can't consume. There is no such thing as gluten in IV. They always have fruits and juices at hospitals, you can ask for those. Staff in an ER, will always be very kind...

A ketogenic diet is good if you are trying to lose weight, lower insulin levels, fight diabetes, lower blood sugar, etc. . But I'm 20 years old, 5'9 165lbs, that's not healthy for me. I am extremely active and need carbohydrates. In fact I definitely need more because I am lower than 12% body fat...

I pretty much do all of that with the exception of parchment paper. I tried telling them about the loose flower and they look at me like I'm being some controlling a**hole. I'm too poor to afford extra paper towels and parchment paper. I can't seem to get them to understand how serious it is. I d...

Vitamin deficiencies of vitamins D, C, and B12 and Calcium deficiency can all cause night sweats. (Perhaps the methyl form of B12 is needed for those with that MthFr gene.) Also, consistently high blood sugar levels can cause night sweats. As a type two diabetic, I find if my blood sugar...