Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Sky High Tissue Transglutaminaise Igg ?

BeautifulSkunk

Recommended Posts

BeautifulSkunk Newbie
BeautifulSkunk
Posted

My ten year old daughter has been struggling with GI issues since 2011. For the first two years, we were told that she had ulcerative colitis. We had a change of doctors within the same clinic and the new one advised us that she had Crohn's (according to her medical file). Ugh!

We've recently moved to a new clinic, citing incompetence at the old one, and I requested all lab results sent to me.

The lab work seems to be indicative of Celiac but I'm so confused at this point... Take a look.

Tissue Transglutaminaise antibodies

tTG IgA 3 (0-15)

tTG IgG 122 (0-15)

ESR Westegren Sedimentation Rate

ESR 26 (0-16)

IgA (Immunoglobulin A)

IgA 223 (25-200)

Can anyone help me interpret this?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


LauraTX Rising Star
LauraTX
Posted

You are correct that her IgG ttg is hugely high.  I think it is a good idea to push for further investigation of that, definitely an endoscopy if she is currently consuming gluten.

nvsmom Community Regular
nvsmom
Posted

According to the following site, the specificity of the tTG IgG is 95% so a positive that high is most likely due to celiac disease.Open Original Shared Link[tt_news]=172034  I would assume celiac disease at this point.

 

I agree that you might want more blood tests and/or and endoscopic biopsy.  The rest of the celiac tests are

tTG IgA and tTG IgG (repeat testing can be helpful)

DGP IgA and DGP IgG - very good tests for early celiac disease

EMA IgA

AGA IgA and AGA IgG - older and less reliable tests

(total serum IgA - run to make sure there is enough IgA for accurate testing - hers is more than fine)

 

For accurate tests one must be eating 1-2 slices of bread per day (or equivalent) in the 8-12 weeks prior to testing. The biopsy only requires a 2-4 week gluten challenge.

 

A high sed rate can mean inflammation due to autoimmune disease (like celiac disease), infection or a few other things. A high sed rate is not uncommon in untreated celiacs.

 

More information on testing and pediatric celiac disease below:

Open Original Shared Link

Open Original Shared Link
 
Best wishes. I hope you find answers.
BeautifulSkunk Newbie
BeautifulSkunk
Posted
  • Author

She had a biopsy done at this same time and it seemed to contain high markers for celiac as well. For instance, the biopsy of the duodenum was positive for villous atrophy and increased epithelial lymphocytes. 

 

Since requesting copies of this lab work...(Did I mention that this lab and histopathology was from 2011?) I have taken her off of gluten. She was getting really sick (lots of diarrhea and anemia). If gluten was the villain here, I didn't feel like she could wait.

To be honest, I'm probably leaning on the hope that this has been the answer that someone missed along the way. A lifetime of dealing with a gluten intolerance seems a little less scary than the unknowns of Crohn's. 

 

And please, I don't mean to offend or make light of Coeliac. 

kareng Grand Master
kareng
Posted

These tests are from 2011? The doctor never said a thing to you? Wow!

We completely understand that Celiac is better than some other diseases. So don't worry about that.

LauraTX Rising Star
LauraTX
Posted

Wow, looks like they completely missed the diagnosis.  What a shame.

BeautifulSkunk Newbie
BeautifulSkunk
Posted
  • Author

Wow, looks like they completely missed the diagnosis.  What a shame.

Yes! I can hardly wait to talk to her present gastroenterologist tomorrow. I've been pretty consumed with these lab papers this weekend. I feel like I've learned a ton. I can only hope that I'm not overlooking something. 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


nvsmom Community Regular
nvsmom
Posted

:( Oh geez. Her doctors really blew it, didn't they?

 

Good luck with going gluten-free. I hope she has a speedy recovery.

 

Oh, and you should get the rest of the family checked every 2 years as celiac disease has a genetic component to it.

BeautifulSkunk Newbie
BeautifulSkunk
Posted
  • Author

Thank you for the advice/encouragement. I'll update after I've talked with her doctor.

BeautifulSkunk Newbie
BeautifulSkunk
Posted
  • Author

Well...the doctor didn't call me today like he said he would but I know that they can get busy.

 

In the mean time, I have another question.

 

One of the appalling things we found out when things first came to a head in 2011 was that my daughter, who was seven at the time, thought that a "normal" stool was diarrhea. I never paid much attention to her stools much past the point that I quit wiping her bottom for her and that was several years before when she was potty trained as a toddler. So...she had been sick for some time before diagnosis. 

Back to my question.

She started having bloody stools and from what I've read, that's not characteristic of celiac. However, do you suppose that the years of irritation/allergy could have taken it's toll on her gut? Has anyone else had blood in the stool as a symptom? 

 

I've already noted what the biopsy said about the duodenal area. The gastric biopsy indicated mild chronic gastritis and the various colon biopsies indicated chronic active colitis with cryptitis, crypt distortion, and focal mucosal erosion. Every part was negative for dysplasia and granuloma. 

 

It's all so curious. I still can't find Crohn's in any of that.

kareng Grand Master
kareng
Posted

Well...the doctor didn't call me today like he said he would but I know that they can get busy.

 

In the mean time, I have another question.

 

One of the appalling things we found out when things first came to a head in 2011 was that my daughter, who was seven at the time, thought that a "normal" stool was diarrhea. I never paid much attention to her stools much past the point that I quit wiping her bottom for her and that was several years before when she was potty trained as a toddler. So...she had been sick for some time before diagnosis. 

Back to my question.

She started having bloody stools and from what I've read, that's not characteristic of celiac. However, do you suppose that the years of irritation/allergy could have taken it's toll on her gut? Has anyone else had blood in the stool as a symptom? 

 

I've already noted what the biopsy said about the duodenal area. The gastric biopsy indicated mild chronic gastritis and the various colon biopsies indicated chronic active colitis with cryptitis, crypt distortion, and focal mucosal erosion. Every part was negative for dysplasia and granuloma. 

 

It's all so curious. I still can't find Crohn's in any of that.

Well...the doctor didn't call me today like he said he would but I know that they can get busy.

 

In the mean time, I have another question.

 

One of the appalling things we found out when things first came to a head in 2011 was that my daughter, who was seven at the time, thought that a "normal" stool was diarrhea. I never paid much attention to her stools much past the point that I quit wiping her bottom for her and that was several years before when she was potty trained as a toddler. So...she had been sick for some time before diagnosis. 

Back to my question.

She started having bloody stools and from what I've read, that's not characteristic of celiac. However, do you suppose that the years of irritation/allergy could have taken it's toll on her gut? Has anyone else had blood in the stool as a symptom? 

 

I've already noted what the biopsy said about the duodenal area. The gastric biopsy indicated mild chronic gastritis and the various colon biopsies indicated chronic active colitis with cryptitis, crypt distortion, and focal mucosal erosion. Every part was negative for dysplasia and granuloma. 

 

It's all so curious. I still can't find Crohn's in any of that.

Were they treating the colitis?

BeautifulSkunk Newbie
BeautifulSkunk
Posted
  • Author

At the time of the biopsies they had not been treating the colitis.

BeautifulSkunk Newbie
BeautifulSkunk
Posted
  • Author

They've treated her repeatedly with prednisone. Additionally, she has taken, first, Pentasa and, currently, Imuran. Neither the Pentasa nor the Imuran has worked. Only the prednisone. But she can't stay on that continually.

BeautifulSkunk Newbie
BeautifulSkunk
Posted
  • Author

Still no response from the doctor. I'm trying to give the benefit of the doubt here and am believing that he is just taking his time reviewing all of her chart information.  :unsure:

nvsmom Community Regular
nvsmom
Posted

:( I hope you hear soon - waiting is hard!

 

Bloody stools can be caused by irritation and hemorrhoids.  I know she seems young for that but that D irritation could cause it.  I had C problems in my past, but I had visible hemorrhoids by around age 20 and bloody stools are not uncommon.... Something to ask the doctors about - they know more than me.  :)

 

Good luck.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. Scott Adams
      0

      How Thyroid and Celiac Disease Raise the Risk of Future Type 1 Diabetes (+Video)

    2. knitty kitty
      - knitty kitty replied to xxnonamexx's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      23

      My journey is it gluten or fiber?

      No, Life Extension contains Benfotiamine and Thiamine Hydrochloride. Objective Nutrients Thiamax contains TTFD. I take both of these and a B Complex.
    3. xxnonamexx
      - xxnonamexx replied to xxnonamexx's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      23

      My journey is it gluten or fiber?

      what Benfotiamine should I take as Life Extension contains both Ben and TTFD.
    4. knitty kitty
      - knitty kitty replied to xxnonamexx's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      23

      My journey is it gluten or fiber?

      I take both Benfotiamine and TTFD. You might want to start with the Benfotiamine for a few days and then add in the TTFD. You can look for NeuroMag (Magnesium Threonate). A magnesium glycinate is fine, too. Doctor's Best is a good brand. Don't take more than 300mg total per day of magnesium or it may have a laxative effect. Be sure...
    5. xxnonamexx
      - xxnonamexx replied to xxnonamexx's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      23

      My journey is it gluten or fiber?

      Life Extension Benfotiamine with Thiamine has 100MG of Ben and 25 of Thia..... Do you think this is the one I should take or Objective Nutrients Thiamax (TTFD) which has 100MG Thiamine. How much magnesium should I look for? I take the womens 50+ multivitamin since consumerlabs stated and tested that it has the right amount of vitamins and not too much for...
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      132,771
    • Most Online (within 30 mins)
      7,748
    Tennis Tony
    Newest Member
    Tennis Tony
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • knitty kitty
      My journey is it gluten or fiber?

      By knitty kitty · Posted

      No, Life Extension contains Benfotiamine and Thiamine Hydrochloride. Objective Nutrients Thiamax contains TTFD.     I take both of these and a B Complex.  
    • xxnonamexx
      My journey is it gluten or fiber?

      By xxnonamexx · Posted

      what Benfotiamine should I take as Life Extension contains both Ben and TTFD.
    • knitty kitty
      My journey is it gluten or fiber?

      By knitty kitty · Posted

      I take both Benfotiamine and TTFD.   You might want to start with the Benfotiamine for a few days and then add in the TTFD.   You can look for NeuroMag (Magnesium Threonate).  A magnesium glycinate is fine, too.  Doctor's Best is a good brand.  Don't take more than 300mg total per day of magnesium or it may have a laxative effect.   Be sure to take the B Complex.  The Benfotiamine and TTFD will need the other B vitamins.  
    • xxnonamexx
      My journey is it gluten or fiber?

      By xxnonamexx · Posted

      Life Extension Benfotiamine with Thiamine has 100MG of Ben and 25 of Thia..... Do you think this is the one I should take or Objective Nutrients Thiamax (TTFD) which has 100MG Thiamine. How much magnesium should I look for? I take the womens 50+ multivitamin since consumerlabs stated and tested that it has the right amount of vitamins and not too much for men and doesn't have BHT which has shown to cause liver cancer in animals. I was never big with multivitamins as well as doctors I just read when I was first going gluten free to take a multi but I think I will stop them and work on trying the super B Thia and Ben, Mag.  
    • Oliverg
      Glutened

      By Oliverg · Posted

      Hi all I’ve been celiac for 4 years now, I’ve done pretty well to avoid it thus far. Last night I took the wrong pizza out of the freezer and ate the whole lot!! The non gluten and gluten pizza boxes are both very similar.   2 hours later I was throwing up violently on my hands and knees over the loo.  .horrendous stomach pains,  My hair was wet from sweat every part of my body was wet. What an awful experience, just had a bad headache today  fortunately.    Is their any products/pills anyone takes if they have realised they have just been glutened to make the symptoms a little less worse.  thanks  
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.