Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

What do you make of my results?

Rocky73

Recommended Posts

Rocky73 Newbie
Rocky73
Posted

Hi All,

Was wondering whether you can help me interpret my results please. 

I do generally feel very good but have been plagued by some gastro issues on and off since beginning of July which I put down to stress but currently feeling great. Have also in parallel found out I was iron, vitamin d, magnesium and zinc deficient and currently taking supplements for all. 

My gastro did some blood tests and results came back as follows and I was wondering what you would make of it. Have an appointment scheduled for discussion and biopsy on Nov 4.

Deamidated Gliadin IgA <2 RU/ml  (Ref. <25 Negative)

Anti Tissue Transglutaminase  IGA 38.41 RU/ml (Ref. more than 20 RU/ml: Positive)

Immunoglobulin A 2.23 g/l (Ref. 0.7 to 4 g/l)

My question is if positive TTG is indicative of celiac shouldn't gliadin have been positive too??

Thanks for your answers!

Rocky 73

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


nvsmom Community Regular
nvsmom
Posted

Hi All,

Was wondering whether you can help me interpret my results please. 

I do generally feel very good but have been plagued by some gastro issues on and off since beginning of July which I put down to stress but currently feeling great. Have also in parallel found out I was iron, vitamin d, magnesium and zinc deficient and currently taking supplements for all. 

My gastro did some blood tests and results came back as follows and I was wondering what you would make of it. Have an appointment scheduled for discussion and biopsy on Nov 4.

Deamidated Gliadin IgA <2 RU/ml  (Ref. <25 Negative)

 

Anti Tissue Transglutaminase  IGA 38.41 RU/ml (Ref. more than 20 RU/ml: Positive)

 

Immunoglobulin A 2.23 g/l (Ref. 0.7 to 4 g/l)

 

 

My question is if positive TTG is indicative of celiac shouldn't gliadin have been positive too??

Thanks for your answers!

Rocky 73

No, I'm afraid not.  Celiacs who are positive in all tests appear to be a (large) minority. It is very common to be positive in one test, negative in a nother test, or even have a negative biopsy with positive tests (or vice versa).  That's part of the reason this pre-testing forum is so well used.  ;)

It is suggested that people get as many tests run as possible for that very reason.  Celiac tests are not perfect.  They miss up to a quarter (or more in the old AGA tests) of all celiacs.

The ttG IgA misses up to 25% of all celiacs but it's specificity (% of positives caused by celiac) is at about 95%. This means if you had a negative ttG IgA you still have a 25% chance of being a celiac.  A positive tTG IgA means you have a 5% chance of that (weak) positive being caused by another autoimmune issue or a sickness (it is almost always a weak positive though - a 21 for your labs).

The DGP IgA is a good test, but it can miss 4-18% of celiacs.  You could be one of those.

My guess is that you have celiac disease.  A positive is generally a positive. 

If you want to be sure then request more testing get the DGP IgG, tTG IgG, EMA IgA, and the endoscopic biopsy (6+ samples taken). You could also get genetic testing done for the DQ2 and DQ8 genes, but that will just tell you if you are in the higher risk group of developing celiac disease. About 97% of all celiacs have at least one of those genes.

How is your doctor handling it?

Rocky73 Newbie
Rocky73
Posted
  • Author

Thank you - makes a lot of sense when you put it like this. Will be really gutted if this is going to be final diagnosis though. I am quite shocked about it actually. It doesn't run in the  family and like I said I don't really have any symptoms at all at the moment so did not see this coming at all :mellow:

I am seeing the doctor on November 4 for the biopsy.. Have not spoken to her since lab test; only the nurse who called to schedule biopsy as soon as blood work came back.  Not sure whether she plans on running more blood tests when I go in but will definitely  mention it. 

Thanks again for answering - it's great to have forums like these!

 

cyclinglady Grand Master
cyclinglady
Posted

Thank you - makes a lot of sense when you put it like this. Will be really gutted if this is going to be final diagnosis though. I am quite shocked about it actually. It doesn't run in the  family and like I said I don't really have any symptoms at all at the moment so did not see this coming at all :mellow:

I am seeing the doctor on November 4 for the biopsy.. Have not spoken to her since lab test; only the nurse who called to schedule biopsy as soon as blood work came back.  Not sure whether she plans on running more blood tests when I go in but will definitely  mention it. 

Thanks again for answering - it's great to have forums like these!

 

Keep eating gluten until all testing is complete!  

squirmingitch Veteran
squirmingitch
Posted

I'm going to repeat what cyclinglady said because it bears repeating. CONTINUE EATING GLUTEN UNTIL YOU ARE SURE ALL TESTING IS COMPLETED. Otherwise you can get a false negative & you don't want that. 

BTW, you DO have symptoms.....

"iron, vitamin d, magnesium and zinc deficient"

Do you know what prolonged deficiency in these will do to you over time? We do. We've been there and further. You don't want to go there. It's like slowly dying. Also, you may think you don't have any symptoms but once you go gluten free you might just be surprised by the things you thought were normal but have disappeared.

nvsmom Community Regular
nvsmom
Posted

.... Also, you may think you don't have any symptoms but once you go gluten free you might just be surprised by the things you thought were normal but have disappeared.

That is so true! It's astonishing the wide variety of damage an innocent PB&J sandwich can cause.

Rocky73 Newbie
Rocky73
Posted
  • Author

yeah no worries about me not eating any gluten :rolleyes: I am eating loads at the moment. Making the most of it until I know for sure that I am one of you. Should I continue with the supplements too?

Will keep you posted on my biopsy results and final diagnosis and thanks again for all your replies. Really appreciate it! 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


squirmingitch Veteran
squirmingitch
Posted

The supplements certainly won't hurt you at this point so go ahed & keep taking them. Down the line you'll want to make sure they're gluten free though.

Yes, please update us when you get results. 

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,912
    • Most Online (within 30 mins)
      7,748
    westman3d
    Newest Member
    westman3d
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Rogol72
      Help I’m cross contaminating myself,

      By Rogol72 · Posted

      @klmgarland, My dermatitis herpetiformis didn't clear up until I became meticulous about cross contamination. I cut out gluten-free oats and all gluten-free foods, dairy and gluten-free rice. Additionally, getting the right amount of protein for my body weight helped significantly in my body's healing process ... along with supplementing with enough of all the vitamins and minerals ... especially Zinc and Magnesium. I went from 70kg to 82kg in a year. Protein with each meal 3 times daily, especially eggs at breakfast made the difference. I'm not sure whether iodine was a problem for me, but I can tolerate iodine no problem now. I'm off Dapsone and feel great. Not a sign of an itch. So there is hope. I'm not advocating for the use of Dapsone, but it can bring a huge amount of relief despite it's effect on red blood cells. The itch is so distracting and debilitating. I tried many times to get off it, it wasn't until I implemented the changes above and was consistent that I got off it. Dermatitis Herpetiformis is horrible, I wouldn't wish it on anyone.  
    • klmgarland
      Help I’m cross contaminating myself,

      By klmgarland · Posted

      Thank you so very much Scott.  Just having someone understand my situation is so very helpful.  If I have one more family member ask me how my little itchy skin thing is going and can't you just take a pill and it will go away and just a little bit of gluten can't hurt you!!!! I think I will scream!!
    • Scott Adams
      Help I’m cross contaminating myself,

      By Scott Adams · Posted

      It is difficult to do the detective work of tracking down hidden sources of cross-contamination. The scenarios you described—the kiss, the dish towel, the toaster, the grandbaby's fingers—are all classic ways those with dermatitis herpetiformis might get glutened, and it's a brutal learning curve that the medical world rarely prepares you for. It is difficult to have to deal with such hyper-vigilance. The fact that you have made your entire home environment, from makeup to cleaners, gluten-free is a big achievement, but it's clear the external world and shared spaces remain a minefield. Considering Dapsone is a logical and often necessary step for many with DH to break the cycle of itching and allow the skin to heal while you continue your detective work; it is a powerful tool to give you back your quality of life and sleep. You are not failing; you are fighting an incredibly steep battle. For a more specific direction, connecting with a dedicated celiac support group (online or locally) can be invaluable, as members exchange the most current, real-world tips for avoiding cross-contamination that you simply won't find in a pamphlet. You have already done the hardest part by getting a correct diagnosis. Now, the community can help you navigate the rest. If you have DH you will likely also want to avoid iodine, which is common in seafoods and dairy products, as it can exacerbate symptoms in some people. This article may also be helpful as it offers various ways to relieve the itch:  
    • Scott Adams
      My only proof

      By Scott Adams · Posted

      It's very frustrating to be dismissed by medical professionals, especially when you are the one living with the reality of your condition every day. Having to be your own advocate and "fight" for a doctor who will listen is an exhausting burden that no one should have to carry. While that 1998 brochure is a crucial piece of your personal history, it's infuriating that the medical system often requires more contemporary, formal documentation to take a condition seriously. It's a common and deeply unfair situation for those who were diagnosed decades ago, before current record-keeping and testing were standard. You are not alone in this struggle.
    • Scott Adams
      Methylprednisone treatment for inflammation?

      By Scott Adams · Posted

      Methylprednisolone is sometimes prescribed for significant inflammation of the stomach and intestines, particularly for conditions like Crohn's disease, certain types of severe colitis, or autoimmune-related gastrointestinal inflammation. As a corticosteroid, it works by powerfully and quickly suppressing the immune system's inflammatory response. For many people, it can be very effective at reducing inflammation and providing rapid relief from symptoms like pain, diarrhea, and bleeding, often serving as a short-term "rescue" treatment to bring a severe flare under control. However, experiences can vary, and its effectiveness depends heavily on the specific cause of the inflammation. It's also important to be aware that while it can work well, it comes with potential side effects, especially with longer-term use, so it's typically used for the shortest duration possible under close medical supervision. It's always best to discuss the potential benefits and risks specific to your situation with your gastroenterologist.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.