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Question about PPV and NPV of TTG and EMA

Alibu

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Alibu Explorer
Alibu
Posted

As I wait (impatiently) for my biopsy results, I've been doing a lot of research about my conflicting test results (positive TTG at 11, where positive is anything over 4, and negative EMA). 

Everything I've been reading has said that  TTG has a positive predictive value of about 90% and that EMA has a negative predictive value of 100%. 

So according to that, I have a 90% chance of a positive biopsy, but also a 100% chance of a negative biopsy.

I also was reading a study where a positive TTG and negative EMA combo resulted in very low positive biopsy results in the study group. 

Thoughts?  Yes, I'm going crazy waiting for my results, LOL. 

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cyclinglady Grand Master
cyclinglady
Posted

I know!  It is SO hard to be patient!  

Again, your results are not really conflicting.  You only needed one positive on the panel.    I have never had a positive TTG or an EMA (just the DGP IgA).   You can go crazy reviewing studies.  Please note that not all of them are good or they can be very small which almost makes them useless.  

Maybe focus on what you do know.  Why did you develop the hernia and what are the treatments?   If you have EOE, how are you going to handle that?   You might be giving up wheat even if you do not have celiac disease, should wheat be a trigger for EOE.  

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To get your mind off your health, go do something fun, even better, do something nice for someone else!  

Alibu Explorer
Alibu
Posted
  • Author
3 hours ago, cyclinglady said:

I know!  It is SO hard to be patient!  

Again, your results are not really conflicting.  You only needed one positive on the panel.    I have never had a positive TTG or an EMA (just the DGP IgA).   You can go crazy reviewing studies.  Please note that not all of them are good or they can be very small which almost makes them useless.  

Maybe focus on what you do know.  Why did you develop the hernia and what are the treatments?   If you have EOE, how are you going to handle that?   You might be giving up wheat even if you do not have celiac disease, should wheat be a trigger for EOE.  

Open Original Shared Link

To get your mind off your health, go do something fun, even better, do something nice for someone else!  

I know, I know!  I'm so impatient, LOL!!  I'm just one of those people who does not do well in limbo.  So I know want to KNOW, which makes me try to seek out answers.  

 

I've had a hiatal hernia for years and years, as I've had reflux since I was like 18 (I'm 41 now).  I guess the other stuff, I just don't know.  I think it depends on what they find and what the doctor thinks is the next best step, which again, puts me in limbo.

But you're right, I need to just keep myself busy and do something else....it's Christmas Eve and I'm about to spend some quality family time, so that helps!!  Thank you for your dose of rationality and reason!!

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      In the study linked above, the little girl switched to a gluten free diet and gained enough weight that that fat pad was replenished and surgery was not needed.   Here's the full article link... Superior Mesenteric Artery Syndrome in a 6-Year-Old Girl with Final Diagnosis of Celiac Disease https://pmc.ncbi.nlm.nih.gov/articles/PMC6476019/
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      Hello, @Jordan Carlson, So glad you're feeling better.   Tecta is a proton pump inhibitor.  PPI's also interfere with the production of the intrinsic factor needed to absorb Vitamin B12.  Increasing the amount of B12 you supplement has helped overcome the lack of intrinsic factor needed to absorb B12. Proton pump inhibitors also reduce the production of digestive juices (stomach acids).  This results in foods not being digested thoroughly.  If foods are not digested sufficiently, the vitamins and other nutrients aren't released from the food, and the body cannot absorb them.  This sets up a vicious cycle. Acid reflux and Gerd are actually symptoms of producing too little stomach acid.  Insufficient stomach acid production is seen with Thiamine and Niacin deficiencies.  PPI's like Tecta also block the transporters that pull Thiamine into cells, preventing absorption of thiamine.  Other symptoms of Thiamine deficiency are difficulty swallowing, gagging, problems with food texture, dysphagia. Other symptoms of Thiamine deficiency are symptoms of ADHD and anxiety.  Vyvanse also blocks thiamine transporters contributing further to Thiamine deficiency.  Pristiq has been shown to work better if thiamine is supplemented at the same time because thiamine is needed to make serotonin.  Doctors don't recognize anxiety and depression and adult onset ADHD as early symptoms of Thiamine deficiency. Stomach acid is needed to digest Vitamin C (ascorbic acid) in fruits and vegetables.  Ascorbic acid left undigested can cause intestinal upsets, anxiety, and heart palpitations.   Yes, a child can be born with nutritional deficiencies if the parents were deficient.  Parents who are thiamine deficient have offspring with fewer thiamine transporters on cell surfaces, making thiamine deficiency easier to develop in the children.  A person can struggle along for years with subclinical vitamin deficiencies.  Been here, done this.  Please consider supplementing with Thiamine in the form TTFD (tetrahydrofurfuryl disulfide) which helps immensely with dysphagia and neurological symptoms like anxiety, depression, and ADHD symptoms.  Benfotiamine helps with improving intestinal health.  A B Complex and NeuroMag (a magnesium supplement), and Vitamin D are needed also.
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      26F!
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