Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Low IgA, dr won’t test IgG


Runningyogi

Recommended Posts

Runningyogi Rookie

Just wondering how common this is. I had tTg-IgA and gliandin IgA tested and they both came back at 2, which is without a doubt a “negative result.” However my IgA was 48, the lab cited 79-335 as “normal” and flagged me as low. My PCP said the test shows no celiac, I had already googled and discovered the low IgA situation so I asked her about testing IgG and she said it wasn’t necessary. 

 

Is my IgA just not low enough? I obviously make the antibody just not at a normal level. 

Has anyone else been told this, if so did you push for further testing or get a second opinion? I’m mostly trying to just rule some things out, my son has EoE so it’s not totally unlikely im suffering from something more than IBS. Thanks!


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



kareng Grand Master
(edited)
5 minutes ago, Runningyogi said:

Just wondering how common this is. I had tTg-IgA and gliandin IgA tested and they both came back at 2, which is without a doubt a “negative result.” However my IgA was 48, the lab cited 79-335 as “normal” and flagged me as low. My PCP said the test shows no celiac, I had already googled and discovered the low IgA situation so I asked her about testing IgG and she said it wasn’t necessary. 

 

Is my IgA just not low enough? I obviously make the antibody just not at a normal level. 

Has anyone else been told this, if so did you push for further testing or get a second opinion? I’m mostly trying to just rule some things out, my son has EoE so it’s not totally unlikely im suffering from something more than IBS. Thanks!

Your total IGA is not too low for Celiac testing.  The test range isn't specific to Celiac.

"Any level of IgA above 20 mg/dl should make the tTG-IgA test valid, regardless of age."

Open Original Shared Link

 

Edited by kareng
cyclinglady Grand Master
(edited)

Your Immunoglobulin A (IgA) is low or below range, but it is enough to determine if the celiac tests work.  It would have to be close to zero.    So, two negatives is probably correct.  However, some celiacs are seronegative.  Some, like me, do not test positive to all the celiac tests (DGP, TTG and EMA).  (I test positive to only the DGP).  Some people at the time of testing might gluten free or gluten light.  In those cases, an endoscopy may be ordered.  

Do you have any deficiencies like low iron or B-12?  That can also help determine a celiac diagnosis.  Or do you already have another autoimmune disorder, like Hashimoto’s Thyroiditis or autoimmune diabetes?  

I am sorry to hear about your son suffering;g from EOE.  

Edited by cyclinglady
Runningyogi Rookie
41 minutes ago, cyclinglady said:

Your Immunoglobulin A (IgA) is low or below range, but it is enough to determine if the celiac tests work.  It would have to be close to zero.    So, two negatives is probably correct.  However, some celiacs are seronegative.  Some, like me, do not test positive to all the celiac tests (DGP, TTG and EMA).  (I test positive to only the DGP).  Some people at the time of testing might gluten free or gluten light.  In those cases, an endoscopy may be ordered.  

Do you have any deficiencies like low iron or B-12?  That can also help determine a celiac diagnosis.  Or do you already have another autoimmune disorder, like Hashimoto’s Thyroiditis or autoimmune diabetes?  

I am sorry to hear about your son suffering;g from EOE.  

I suffered from low iron for a few years but then had an IUD placed and my iron levels have been normal since.  No other autoimmune that I know of. Just a long history of IBS. 

Thanks for your help! 

GFinDC Veteran

I think they say that around 5% of people with celiac disease also have low IgA production.  I'd try another doctor for the complete celiac panel.  There are other antibodies they can test and you might show up positive on one of them.  Maybe search for local celiac support group and ask them for a doctor recommendation.

Runningyogi Rookie
12 hours ago, GFinDC said:

I think they say that around 5% of people with celiac disease also have low IgA production.  I'd try another doctor for the complete celiac panel.  There are other antibodies they can test and you might show up positive on one of them.  Maybe search for local celiac support group and ask them for a doctor recommendation.

 

Thank you! I am seeing lots of conflicting info on low IgA and how it affects the testing. It’s also difficult because when I search most results are for IgA deficiency and not low IgA (deficiency is the close to zero result from what I understand)

i did find a couple of sites that mentioned low IgA specifically and did say to check the IgG, but at this point I feel like a hypochondriac chasing a diagnosis. 

Anyway, thanks for your help everyone. I have a GI appointment next month so I just need to decide if I should trial myself off gluten before hand or wait on the off chance he wants to run another test. I’m just kind of sick of being sick and I’ve felt better off gluten in the past. (I was off gluten due to nursing my wheat, barley and rye allergic son for almost two years)

ravenwoodglass Mentor
1 hour ago, Runningyogi said:

 

Anyway, thanks for your help everyone. I have a GI appointment next month so I just need to decide if I should trial myself off gluten before hand or wait on the off chance he wants to run another test. I’m just kind of sick of being sick and I’ve felt better off gluten in the past. (I was off gluten due to nursing my wheat, barley and rye allergic son for almost two years)

Please wait to go gluten free as if you go gluten free now the doctor won't be able to test you for celiac.  If your son is 'allergic' to wheat, rye and barley it sounds like he may be celiac. Your being diagnosed could help him as well as yourself.


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



Runningyogi Rookie
55 minutes ago, ravenwoodglass said:

Please wait to go gluten free as if you go gluten free now the doctor won't be able to test you for celiac.  If your son is 'allergic' to wheat, rye and barley it sounds like he may be celiac. Your being diagnosed could help him as well as yourself.

He actually outgrew the wheat allergy! Hooray!  He has traditional, IgE mediated, food allergies. He's still allergic to barley and rye.

I think it's probably best to leave the gluten in just in case, even though it really looks like celiac is not what I have. 

erika1petrus Newbie

Hello ? I have low IgA. My doctor said that IgA is the immune protein that keeps one from getting sinus infections & breaks down gluten & dairy in the gut. With low IgA, a celiac test will come back with a “false positive”. I was told to treat myself as if I have celiac disease & that the consequences of eating gluten are the same. I am never supposed to eat gluten or dairy. Hope this helps!

tessa25 Rising Star
21 minutes ago, erika1petrus said:

With low IgA, a celiac test will come back with a “false positive”

Low IGA can cause TTG IGA and DGP IGA celiac tests to show a false negative.

Welcome to the forum!

Runningyogi Rookie
4 hours ago, tessa25 said:

Low IGA can cause TTG IGA and DGP IGA celiac tests to show a false negative.

Welcome to the forum!

Thanks! It’s interesting because the link someone shared above says as long as the IgA is over 20 the test is accurate but I’ve read annecdotal stuff suggesting otherwise. 

cyclinglady Grand Master
39 minutes ago, Runningyogi said:

Thanks! It’s interesting because the link someone shared above says as long as the IgA is over 20 the test is accurate but I’ve read annecdotal stuff suggesting otherwise. 

That link is pretty spot on.  The University of Chicago is a leading celiac research center.  We are discussing testing for celiac disease (used as a control test) and not issues with a low Immunoglobulin A and the health issues that arise from that. 

Some celiacs are seronegative period (rare).   If you think your IgA results are incorrect, then ask for the IgG test versions.   If you  and your GI strongly suspect celiac disease, your GI should order an endoscopy.  

You should remain on gluten until all testing for celiac disease is complete.  Since your GI appointment is just a month away, I would advise sticking to a full gluten diet.  Some research centers advise 2 to 4 weeks prior to an endoscopy.  We have seen too many members who just did 2 weeks and then received a negative biopsy result.  Was it because their bodies were slow to generate antibodies and two weeks was just not long enough?  Who knows?  Now they are in diagnostic limboland.  Use the more conservative number, would be my non-medical advice.  

Keep in mind, that sometimes we jump to conclusions with out all the facts.  I could have sworn my niece had celiac disease.  Turns out it was Crohn’s.  I could have sworn I had active celiac disease with my symptoms and an elevated celiac antibodies.  My recent repeat endoscopy revealed healthy villi.    My  current issues were with a new diagnosis — Chronic Autoimmune Gastritis. 

Runningyogi Rookie

Yeah sorry wasn’t trying to insinuate that the link was wrong. Also, i don’t have any strong feelings that I have celiac. I don’t know WHAT I have unfortunately! I was just trying to rule it out and then I had the low IgA which led to me to researching that and I was curious if that was indicative of something yadda yadda...I fell down an Internet rabbit hole. Lol

  • 3 months later...
pupppy Apprentice

You have iga deficiency... it's called partial iga deficiency. Anything under the range is iga deficient and can invalidate the iga test. According to mayoclinic's algorithm they are supposed to run the igg tests so you are right. I don't know what that other link is saying, but I think you are right

Open Original Shared Link

Open Original Shared Link

pupppy Apprentice

 

On 4/12/2018 at 3:45 PM, cyclinglady said:

Your Immunoglobulin A (IgA) is low or below range, but it is enough to determine if the celiac tests work.  It would have to be close to zero.    So, two negatives is probably correct.  However, some celiacs are seronegative.  Some, like me, do not test positive to all the celiac tests (DGP, TTG and EMA).  (I test positive to only the DGP).  Some people at the time of testing might gluten free or gluten light.  In those cases, an endoscopy may be ordered.  

Do you have any deficiencies like low iron or B-12?  That can also help determine a celiac diagnosis.  Or do you already have another autoimmune disorder, like Hashimoto’s Thyroiditis or autoimmune diabetes?  

I am sorry to hear about your son suffering;g from EOE.  

You're wrong. Partial iga deficiency is still iga deficiency and the doctor is supposed to run igg tests. 

pupppy Apprentice
On 4/12/2018 at 3:42 PM, kareng said:

Your total IGA is not too low for Celiac testing.  The test range isn't specific to Celiac.

"Any level of IgA above 20 mg/dl should make the tTG-IgA test valid, regardless of age."

Open Original Shared Link

 

You and your link are wrong. Algorithms for testing state that if iga is out of range they should test for igg.

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      131,165
    • Most Online (within 30 mins)
      7,748

    melindakathleen
    Newest Member
    melindakathleen
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • DAR girl
      Looking for help sourcing gluten-free products that do not contain potato or corn derived ingredients. I have other autoimmune conditions (Psoriatic Arthritis and Sjogrens) so I’m looking for prepared foods as I have fatigue and cannot devote a lot of time to baking my own treats. 
    • Scott Adams
      I am so sorry you're going through this. It's completely understandable to feel frustrated, stressed, and disregarded after such a long and difficult health journey. It's exhausting to constantly advocate for yourself, especially when you're dealing with so many symptoms and positive diagnoses like SIBO, while still feeling unwell. The fact that you have been diligently following the diet without relief is a clear sign that something else is going on, and your doctors should be investigating other causes or complications, not dismissing your very real suffering. 
    • Oldturdle
      It is just so sad that health care in the United States has come to this.  Health insurance should be available to everyone, not just the healthy or the rich.  My heart goes out to you.  I would not hesitate to have the test and pay for it myself.  My big concern would be how you could keep the results truly private.  I am sure that ultimately, you could not.  A.I. is getting more and more pervasive, and all data is available somewhere.  I don't know if you could give a fake name, or pay for your test with cash.  I certainly would not disclose any positive results on a private insurance application.  As I understand it, for an official diagnosis, an MD needs to review your labs and make the call.  If you end up in the ER, or some other situation, just request a gluten free diet, and say it is because you feel better when you don't eat gluten.      Hang in there, though.  Medicare is not that far away for you, and it will remove a lot of stress from your health care concerns.  You will even be able to "come out of the closet" about being Celiac!
    • plumbago
      Yes, I've posted a few times about two companies: Request a Test and Ulta Labs. Also, pretty much we can all request any test we want (with the possible exception of the N protein Covid test and I'm sure a couple of others) with Lab Corp (or Pixel by Lab Corp) and Quest. I much prefer Lab Corp for their professionalism, ease of service and having it together administratively, at least in DC. And just so you know, Request a Test uses Lab Corp and Quest anyway, while Ulta Labs uses only Quest. Ulta Labs is cheaper than Request a Test, but I am tired of dealing with Quest, so I don't use them so much.
    • Scott Adams
      PS - I think you meant this site, but I don't believe it has been updated in years: http://glutenfreedrugs.com/ so it is best to use: You can search this site for prescriptions medications, but will need to know the manufacturer/maker if there is more than one, especially if you use a generic version of the medication: To see the ingredients you will need to click on the correct version of the medication and maker in the results, then scroll down to "Ingredients and Appearance" and click it, and then look at "Inactive Ingredients," as any gluten ingredients would likely appear there, rather than in the Active Ingredients area. https://dailymed.nlm.nih.gov/dailymed/   
×
×
  • Create New...