Anyone Else A Subtype (5,8)?

[johanna]

I have the DQ8 gene which isn't as common as DQ2. I'm curious about others with similar genes and what their health conditions are b/c I wonder if there are any trends associated with this gene combination. My test results showed problems with gluten and casein. I also have seasonal allergies and a number of mild food allergies. And probably totally unrelated, but b/c there is believed to be a genetic component will mention it--have severe adverse reaction to fluoroquinolones that affect my tendons.

[Nancym]

I have the DQ8 gene which isn't as common as DQ2. I'm curious about others with similar genes and what their health conditions are b/c I wonder if there are any trends associated with this gene combination. My test results showed problems with gluten and casein. I also have seasonal allergies and a number of mild food allergies. And probably totally unrelated, but b/c there is believed to be a genetic component will mention it--have severe adverse reaction to fluoroquinolones that affect my tendons.

I have DQ8 (that's 0302 isn't it?) and also 0501.

I'm also casein intolerant. My symptoms were IBS, autoimmune thryoid disease, lots of joint/muscle aches. I don't have allergies. I think I also get brain fog from gluten. I've heard the 0501 gene is tied to neurological effects of gluten intolerance.

What are fluoroquinolones found in?

[johanna]

It's a class of antibiotics. I took cipro with no problem, but then with avelox I was disabled for a couple of months. Still have mild lasting effects 5 months later. This reaction seems to run in families, but they're not exactly sure what causes it.

[dlp252]

I have the DQ8 gene which isn't as common as DQ2. I'm curious about others with similar genes and what their health conditions are b/c I wonder if there are any trends associated with this gene combination. My test results showed problems with gluten and casein. I also have seasonal allergies and a number of mild food allergies. And probably totally unrelated, but b/c there is believed to be a genetic component will mention it--have severe adverse reaction to fluoroquinolones that affect my tendons.

I have DQ8. Also have seasonal and year round allergies. I have lots of intestinal symptoms and a lot of lightheadedness and brain fog, joint pain, acid reflux, and many more, lol. I am also casein intolerant and have other sensitivities which I haven't nailed down yet. I only showed 4 slight reactions when I had my food allergy test about 3 years ago...there may be more now though.

[Hallie Davis]

I, too have the DQ8 gene. I also have lupus/CREST overlap syndrome (lots of aches and pains), IgG kappa monoclonal gammopathy, some sort of neuropathy (aching, burning hands and feet), with skin nerve biopsies showing progressive loss of nerve fibers), Hashimoto's (autoimmune) thyroiditis with slight goiter and hypothyroidism, mild liver inflammation showing up on PET scan. I was negative for viral hepatitis, and have never drunk more than a couple beers a week, so I suspect this is autoimmune liver inflammation. There are periods of time when my arms go numb every night no matter what pillow (or none) that I use. My 5 herniated discs were definitely NOT present when the arm numbness began. I suspect the CREST is affecting my peripheral circulation, and that may be contributing to the neuropathy. I have mild occasional reflux which can go along with CREST also. I also have osteopenia, and a history of "frozen shoulder". I do not have the celiac antibodies, and a duodenal biopsy was negative for villous atrophy. I do have many allergies, however, including nickel, thimerosal (also mercurachrome, merthiolate and anything else with mercury in the compound), Macrodantin (nitrofurantoin), benzoil peroxide, monocryl and vicryl suture materials, PABA, Monistat, nonoxynol-9. I do not seem to metabolize Ultram or Rozerem properly, possibly because the liver inflammation. The first pill of each of these is okay, but the second dose hours or even a day later, causes an ensuing 18 hours of vomiting. Because treatment for hypothyroidism was delayed for about 4 years, moderate-to-severe obstructive sleep apnea occurred, and I must now sleep with a CPAP machine to keep my airway open.

Because I have so much of the autoimmune stuff that can go with DQ8 and/or celiac disease, even though I don't have celiac disease, I have opted to go gluten free in the hopes that this will lessen my autoimmune problems, and prevent the creation of new ones, such as diabetes and MS.

[RollingAlong]

DH has the DQ8 and DQ5. He is intolerant of gluten and casein and has given them up. The tests show he is allergic to soy and eggs also but they are not totally out of his diet yet.

He had no GI symptoms before accidentally going gluten-free. Instead he seemed to be developing pre-diabetes, despite being slender and exercising. He also had problems with mood, a mild depression or lack of motivation. He needed a great deal of sleep. He was starting to get headaches. Heartburn. And ED, not explosive diarrhea, the viagra kind of ED. On the gluten challenge, he developed new symptoms - a never ending burp, one week long bout of symetrical hives (didn't look like DH, not intensely itchy), fevers/chills and once his fingers and knees got very swollen. (His challenge ended with a negative biopsy. )

He felt the brain fog was related to the casein, or at least, he got a lot of improvement once he went CF.

He has tinnitus, but I am not certain if that's related. Oh, and I forgot about the canker sores - those are gone now!

His sister has ulcerative colitis, which is arguably autoimmune. I think DH was very lucky and caught his gluten problem early, because he's doing a lot better gluten-free/CF. Blood sugar, ED, much improved.

He does not seem to react to gluten now, which makes me nervous. It seems very unlikely he hasn't made any mistakes....

[Mother of Jibril]

I have DQ8 and DQ7 (which are both subtypes of DQ3). I'm intolerant to gluten and corn. Aside from the digestive symptoms, I also have autoimmune hypothyroidism and lots of weird problems with my skin... rosacea, flaky scalp (which seems to be either psoriasis or sebhorreic dermatitis), halo nevi (depigmented areas where my skin is reabsorbing a mole), dermatofibromas (little hard lumps of tissue that I recently found out are benign tumors), acne, autoeczema (an itchy rash in reaction to gluten), and a mysterious rash on my butt that I've had forever and has never been diagnosed as anything in particular. I also have joint pain in my knees, shoulders, and hips that comes and goes... but has mostly been a lot better since I changed my diet. Oh... and chronic dry eyes with inflammation, which requires prescription eye drops and periodic checks for glaucoma.

In addition to celiac disease, DQ8 has been associated with type I diabetes, rheumatoid arthritis, lupus, Sjogren's syndrome, and antiphospholipid syndrome. But... keep in mind that lots of people have these genes without ever getting these disorders (it requires some kind of trigger like severe stress or a virus). Also, a lot of these disorders are based on more than one gene.

[ellie-lynn]

This thread is kind of old, but I'm fascinated by the idea that similar constellations of symptoms might be connected to these different types of genes. For those who know your gene type, I'm wondering how you found out -- did a particular doctor or specialist order the tests? Did you ask for them yourself? I don't know what gene type I have, but my celiac symptoms were more neurological and autoimmune (I had only very subtle GI symptoms). My bloodwork for celiac was off the charts, so they didn't make me do a gluten challenge and biopsy to diagnose.

I'm seeing an allergist for the first time next week, and am wondering if I should ask about the gene testing. I went gluten-free 5 months ago (in December) and had been getting steadily better. I developed joint pain, but that went away with elimination of nightshades. Then in early April my face broke out all over and I started to have mild OAS reactions to foods that had been ok before. I'm thinking maybe it's the pollen, but I'm afraid that this is going to be the start of more new permanent allergies. Anyway, I'd be curious to hear more about if and how celiac patients and docs are using this gene info to troubleshoot symptoms and additional diseases (I developed Hashimoto's autoantibodies, but it hasn't messed up my TSH yet -- am hoping the gluten-free diet will keep this subclinical ...)

[Luvbeingamommy]

This is interesting. To pp, my GI doctor did the Celiac gene test and then I also did with Enterolab which tests for gluten sensitivity also.

I am not familiar with the subtypes, I know I have the one related to neurological problems. I had a stroke in Nov. at 25 years old, nothing was found but celiac, that I pushed for testing. After the gene tests and a TON of other tests, my neurologist believes it's related to the gluten. Kind of still baffles my mind, luckily I recovered well, but it was still scary.

Can anyone tell me what genes I have again??

This is what I have- HLA-DQB1*0201 or HLA-DQB1*0302 and any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302. Not sure exactly what that means, but I did find it was related to neurological issues.