Will my blood test for celiac and biopsy (during endoscopy) still be accurate please? I am new to this. Thanks

[Sotorp]

Hello,
This is my story:
https://www.reddit.com/r/Microbiome/comments/kdwm66/have_severe_symptoms_severe/?utm_medium=android_app&utm_source=share

So,it has been 3 weeks since start of the severe symptoms.
They started since 7.12. Till 14.12 I have been eating  normal bad gluten diet. Since 14.12 to maybe 25.12 I have been eating only very light diet, gluten free and have been feeling mostly better.
Since 25.12 I have been adding new foods (but still eating mostly light gluten free diet), little by little, and trying which makes me feel worse and what does not.
I have felt bad/worse after eating normal bread, spelt bread, and homemade bread made from buckwheat and yeast. But also from beef steak where I added soya sauce.
I think it is either SIBO or Celiac disease.

My question is, since I have been MOSTLY Gluten Free for 3 weeks, and for past week have been trying here and there some new foods,which some have had some gluten in it.. question is:
1. If I went for celiac blood test now, would tests still be accurate? Is 3 weeks enough to heal intestinal damage/make antibodies disappear ? Hope the test would still be as accurate as before.
2. If I went to have endoscopy done now, for biopsy, would it too still be accurate? Or endoscopy does not need me to eat gluten before it?

I have endoscopy on 11.1 (planning to start eating 2 slices of gluten bread every day starting from tommorow), and blood test sometime within january, perhaps after 15.1, will I still have accurate tests?
I have been gluten free for a pretty short time.

Thanks

[trents]

It is more likely that the short period of gluten reduction will not have much impact on the endoscopy/biospy than the blood test, IMO. So I'm guessing that if you have celiac disease the blood tests may not give a strong positive but the biopsy will still show damaged villi.

[Sotorp]

32 minutes ago, trents said:

It is more likely that the short period of gluten reduction will not have much impact on the endoscopy/biospy than the blood test, IMO. So I'm guessing that if you have celiac disease the blood tests may not give a strong positive but the biopsy will still show damaged villi.

In your opinion, is it safe in terms of test accuracy to take Pancreolan while eating gluten foods? 

Not sure if you have it in your country, these are basically pancreatic enzymes that help with digestion.

I am afraid of having severe symptoms again, I am hoping that this would help lessen symptoms before I have biopsy and blood test.

[trents]

I think we have similar things in the USA. I would not think the pancreolan would affect the test results. I am not a doctor, however, so this is lay person opinion.

Edited January 2, 2021 by trents

[Scott Adams]

Technically speaking you risk false negative celiac disease results if you’ve been gluten-free in the weeks leading up to the tests. If your results are negative you could not rule out celiac disease, which, I presume, is one reason why you’re getting the tests in the first place.

[DJFL77I]

no.. it will take many months for antibody to go to 0...  unless yours are very low to begin with...    like if they're only 12 at diagnosis......   that might drop to 0 in a month ?

[Scott Adams]

Maybe, but such results might lead to a doctor telling you it’s not celiac disease “because you’re under 20,” which would be a false conclusion.

[DJFL77I]

mine was 13 when i had it tested in Nov after 5 months..   the lab still said its high...  0 - 3 normal

[Scott Adams]

The number I used, 20, was pulled out of thin air, but the idea is that @Sotorp will have a lower reading than if they were eating gluten daily until the testing was concluded. If the cut off for celiac disease was 10 on a test and they score 7, but were gluten-free for a time before the test, what exactly will that tell you? Many doctors would tell them that they don't have celiac disease and can keep eating gluten. I think what I'm trying to say is that it's very important not to go gluten-free before testing, and if this somehow happens then you can't really read too much into the results. 

[docaz]

Since you went gluten-free only a short time ago, it might make sense to go back now on gluten and to discuss with your doctor how soon you can schedule the blood tests and biopsy. If you go completely guten-free and then need to start a gluten-challenge again, that might require you to go through agony for a long time. Pancreolan appear pancreatic enzyme supplements and these do not affect gluten.