DQ6 and Celiac

[AuntieAutoimmune]

Does anyone here have any knowledge of studies that were done in India that showed that HLA DQ6 can be an indicator for a form of Celiac disease? This form appears to attack people neurologically as well as gastrointestinal. I learned about this from a nurse who is very involved in the gluten-free community. I am a double DQ6, and before being diagnosed with NCGS, I could barely walk, and I had all of the gastro issues, too, including mouth sores. To date, I have been diagnosed with Sjogren's, Hashimoto's, and Raynaud's.

I have always said that my form of NCGS would someday be classified as autoimmune, and I am trying to find out more. Any help appreciated. Thank you!  

[trents]

Auntie, I tend to agree with you. My impression is that the more we learn about gluten-related disorders the more we realize they don't very well fit our former neat little categories that reflected the assumption that they were separate and distinct conditions. My observation is that many of our forum participants who have been diagnosed with NCGS have neurological manifestations. And I think it is becoming obvious as more research is done that we have a very incomplete picture of the genetics of gluten-related disorders.

Edited July 12, 2022 by trents

[Wheatwacked]

 It might have been an article here on Celiac.com. I did find one from 2021.

"People with two copies of specific genes, such as HLA-DQ7 (a form of HLA-DQ3 that's similar to HLA-DQ8), risk very strong reactions to gluten, just as people with two copies of HLA-DQ2 can develop very severe celiac disease, [Dr Fine] says."  Do You Need Specific Genes to Have Gluten Sensitivity?

 

[AuntieAutoimmune]

Thank you so much, Wheatwacked! 

[Posterboy]

On 7/12/2022 at 10:30 AM, AuntieAutoimmune said:

Does anyone here have any knowledge of studies that were done in India that showed that HLA DQ6 can be an indicator for a form of Celiac disease? This form appears to attack people neurologically as well as gastrointestinal. I learned about this from a nurse who is very involved in the gluten-free community. I am a double DQ6, and before being diagnosed with NCGS, I could barely walk, and I had all of the gastro issues, too, including mouth sores. To date, I have been diagnosed with Sjogren's, Hashimoto's, and Raynaud's.

I have always said that my form of NCGS would someday be classified as autoimmune, and I am trying to find out more. Any help appreciated. Thank you!  

AuntieAutoimmune,

You asked about India....since you are an Auntie I will assume you are from India as well?

Are you from Northern India by chance.

Some of the symptom's you have mentioned can also be confused for Pellagra or more properly Pellagra Sine Pellagra....

Unless you have per fuse skin issues it is probably only the Psuedo Pellagra form of the disease.

Mouth sores can be a sign of Vitamin B2 deficiency.

Here is an article about it....

https://glutenfreeworks.com/health/tongue-magenta-swollen/

This is more noticeable (and common in Northern India) because they have a high dependence on Jowar aka Sorghum....in their diet.....

Here is research about it.....

https://pubmed.ncbi.nlm.nih.gov/744647/  

You can try a gluten free flour made of Sorghum to see if it helps or makes your symptom's worse then you will have your answer.

Here is a nice thread about it...

Taking Niacin aka Nicotinic acid  in low but frequent doses (like 50mg 3x with meals) might be helpful for your skin issues associated with Sjorgen's diagnosis as well!

I wrote a blog post that might be helpful to you.

Good luck on your continued journey!

I hope this is helpful but it is not medical advice.

Posterboy by the grace of God,