spore based probiotics for leaky gut

[Salinas22]

Hi all. New to the celiac forum and newly diagnosed. Working with a functional medical doctor and he’s recommending a spore-soil based probiotic called Megaspore Biotics.  Has anyone ever used this for leaky gut relief/cure? I’m underweight by about 15lbs, I’m a 48M 5’6”.  I can provide much more detail if wanted or needed. 
 

[trents]

Not familiar with it at all.

[RMJ]

I’d be cautious.  The bacillus species are normally a small portion of the intestinal flora.  The company that makes the product published a paper in 2021 studying the product in a model of the human GI system and saying more research was needed in vitro and in vivo. I’d want to see some research studying the product in vivo in humans.

Treatment with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME® model of the human gastrointestinal system

[Salinas22]

  On 8/26/2022 at 12:01 AM, trents said:

Not familiar with it at all.

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Thanks for replying. I may have it a little backwards/wrong. It’s a probiotic that colonizes the small intestine since I’m low on several individual good bacteria strains and low on 2 kingdoms of good strains. This is supposed to produce a healthy strain of bacteria and fight off bad baby which I have a lot of. It’s also supposed to help heal the intestinal vilii therefore helping leaky gut.  

[Salinas22]

  On 8/26/2022 at 12:27 AM, RMJ said:

I’d be cautious.  The bacillus species are normally a small portion of the intestinal flora.  The company that makes the product published a paper in 2021 studying the product in a model of the human GI system and saying more research was needed in vitro and in vivo. I’d want to see some research studying the product in vivo in humans.

Treatment with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME® model of the human gastrointestinal system

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RMJ, thank you so much. I read/skimmed through it and you’re absolutely correct. Testing was done in a SHIME replicated human GI model. They did test on a human but it was a healthy human. Even they say more studies need to be done in vivo. I’m so glad I didn’t take it yet. I read a scary report from someone else who in 2015 took another brand soil/spore based probiotic and it colonized  in his intestines in a very bad way. I’ll pass.