Could someone please give me their input on my blood test results?

[MissMollyMarie]

Hello!  I am so happy that I found this forum! I am beyond confused by my blood test results. 

Could someone please give me their thoughts on my blood test results?  

IgA 299
Gliadin IgA 182.6
Gliadin IgG 3.2
Tissue Transglut IGA Less than 1.9
Endomysial IgA Screen NEGATIVE
Celiac Panel 

I was given these blood tests for diarrhea (yellow) for five months.  I also have nausea and fatigue.  

Thank you for your help/input.  🙂

Miss Molly 

[plumbago]

Happy to help, but we need to see the reference ranges which should be in your report.

[MissMollyMarie]

5 minutes ago, plumbago said:

Happy to help, but we need to see the reference ranges which should be in your report.

I am so sorry!  Of course!

IgA 299 (standard range 68-359 mg/dL)
Gliadin IgA 182.6 (standard range less than 19.9 CU)
Gliadin IgG 3.2 (standard range less than 19.9 CU)
Tissue Transglut IGA Less than 1.9 (standard range less than 19.9 CU)
Endomysial IgA Screen NEGATIVE

[trents]

As Elvis used to croon, "Good golly miss molly!" Welcome to the forum!

Yep, need reference ranges for negative vs. positive since each lab uses different standards for these tests. Oh, I see you have now posted these?

The significantly elevated Gliadin IGA could indicate celiac disease. Now, this is assuming that by Gliadin IGA they intend it to be understood as "Anti-gliadin IGA". If so, it means your are producing inflammatory cells in your gut in reaction to gluten.

Have you had your iron (hemoglobin and ferritin) levels checked?

Has your doctor mentioned scheduling an endoscopy with biopsy to check the condition of your small bowel villous lining? That would be the next step in checking for or confirming celiac disease.

Edited January 27, 2023 by trents

[MissMollyMarie]

1 minute ago, trents said:

As Elvis used to croon, "Good golly miss molly!" Welcome to the forum!

Yep, need reference ranges for negative vs. positive since each lab uses different standards for these tests.

Have you had your iron (hemoglobin and ferritin) levels checked?

He did.  😄

I posted the ranges above.  Hopefully that will help.  I looked through old blood tests and couldn't find those.  Do you mean HEMOGLOBIN A1C? 
 

[trents]

6 minutes ago, MissMollyMarie said:

He did.  😄

I posted the ranges above.  Hopefully that will help.  I looked through old blood tests and couldn't find those.  Do you mean HEMOGLOBIN A1C? 
 

No. Hemoglobiin A1C is a test for elevated blood sugar history (diabetes). Please go back and reread my previous post as I edited it and added some things. I was asking about iron in relation to anemia which could explain your fatigue. A very common phenomenon connected with celiac disease. How about Hematocrit?

Edited January 27, 2023 by trents

[MissMollyMarie]

16 minutes ago, trents said:

As Elvis used to croon, "Good golly miss molly!" Welcome to the forum!

Yep, need reference ranges for negative vs. positive since each lab uses different standards for these tests. Oh, I see you have now posted these?

The significantly elevated Gliadin IGA could indicate celiac disease. Now, this is assuming that by Gliadin IGA they intend it to be understood as "Anti-gliadin IGA". If so, it means your are producing inflammatory cells in your gut in reaction to gluten.

Have you had your iron (hemoglobin and ferritin) levels checked?

Has your doctor mentioned scheduling an endoscopy with biopsy to check the condition of your small bowel villous lining? That would be the next step in checking for or confirming celiac disease.

Found it! 

Homoglobin 14.3 (standard range 11.5-15.4) in March of 2022
I don't believe I've had a ferritin blood test.

Do you feel like this could be a blood cancer of some sort?

18 minutes ago, trents said:

As Elvis used to croon, "Good golly miss molly!" Welcome to the forum!

Yep, need reference ranges for negative vs. positive since each lab uses different standards for these tests. Oh, I see you have now posted these?

The significantly elevated Gliadin IGA could indicate celiac disease. Now, this is assuming that by Gliadin IGA they intend it to be understood as "Anti-gliadin IGA". If so, it means your are producing inflammatory cells in your gut in reaction to gluten.

Have you had your iron (hemoglobin and ferritin) levels checked?

Has your doctor mentioned scheduling an endoscopy with biopsy to check the condition of your small bowel villous lining? That would be the next step in checking for or confirming celiac disease.

IgA 299 (standard range 68-359 mg/dL)
Gliadin IgA 182.6 (standard range less than 19.9 CU)
Gliadin IgG 3.2 (standard range less than 19.9 CU)
Tissue Transglut IGA Less than 1.9 (standard range less than 19.9 CU)
Endomysial IgA Screen NEGATIVE

[trents]

No. I'm not thinking any kind of cancer at all.

My first guess would be celiac disease.

My second guess would be NCGS (Non Celiac Gluten Sensitivity).

My third guess would be IBS.

Do you have any pain or cramping? Can we ask your age?

[plumbago]

4 minutes ago, MissMollyMarie said:

Do you feel like this could be a blood cancer of some sort?

If you mean your very normal hemoglobin level - absolutely not. There's no way to tell, just looking at that, the first thing about cancer.

The only abnormal reading is the IgA gliadin. Everything else is normal. I would keep eating gluten and then retest. They say only one negative test result indicates Celiac. But me in your shoes, I'd repeat the panel. If it comes back more or less the same, talk to your gastroenterologist about getting in for an upper endoscopy (EGD) in order to biopsy parts of the small intestine to confirm and to see how much damage (if any) there is.

[MissMollyMarie]

14 minutes ago, trents said:

No. Hemoglobiin A1C is a test for elevated blood sugar history (diabetes). Please go back and reread my previous post as I edited it and added some things. I was asking about iron in relation to anemia which could explain your fatigue. A very common phenomenon connected with celiac disease. How about Hematocrit?

I reread.  Thank you.  This was in July of 2022.
Homoglobin 14.3 (standard range 11.5-15.4)
Hematocrit 42.7 % (standard range 36.0 - 46.0 %)

 

[MissMollyMarie]

8 minutes ago, trents said:

No. I'm not thinking any kind of cancer at all.

My first guess would be celiac disease.

My second guess would be NCGS (Non Celiac Gluten Sensitivity).

My third guess would be IBS.

Do you have any pain or cramping? Can we ask your age?

I'm sorry if I am slow in responding.  I am trying to figure out how this form works.  I'm not very tech savvy. 😄

Oh, good. I've read a lot about blood cancers and liver disease with a high number like that.  Would you consider my Gliadin IgA (182.6) to be abnormally high?  More than most people?  

I have abdominal pain and cramping.  I have had that for years. The yellow stools and constant diarrhea have only been for the past five months.  I will turn 59 next month. 

[trents]

If I were you, I'd push for an upper GI with biopsies taken of the duodenum and duodenum bulb (the two areas of the small bowel where celiac disease damages the villi that line the area). This would be to check for celiac disease but in the process he would also look at your esophagus and your stomach for ulcers and a biopsy should be done to check for H. Pylori, a gastric infection that causes most peptic ulcers.

Liver disease could cause light colored stools. You would need a CMP (Complete metabolic panel) to check for elevated liver enzymes. By the way, elevated liver enzymes are common with celiac disease and in fact, it was what led to my diagnosis of celiac disease.

[MissMollyMarie]

35 minutes ago, plumbago said:

If you mean your very normal hemoglobin level - absolutely not. There's no way to tell, just looking at that, the first thing about cancer.

The only abnormal reading is the IgA gliadin. Everything else is normal. I would keep eating gluten and then retest. They say only one negative test result indicates Celiac. But me in your shoes, I'd repeat the panel. If it comes back more or less the same, talk to your gastroenterologist about getting in for an upper endoscopy (EGD) in order to biopsy parts of the small intestine to confirm and to see how much damage (if any) there is.

I truly appreciate your input and help.  I feel better.  I will definitely talk to my doctor about an upper endoscopy.  Thank you again. ☺️

[trents]

Keep us posted.

A word of caution, though. Don't attempt to reduce your gluten consumption until all testing is complete for celaic disease. If you do decide to trial  the gluten free diet, you would need to go off it at least two weeks ahead of time and go back to consuming the amount of gluten equivalent to two slices of wheat bread daily. If you would be repeating celiac antibody tests then that time period of returning to gluten consumption extends out to 6-8 weeks prior to the blood draw. These are the guidelines given by the Mayo Clinic to prevent invalidating the tests.

[Wheatwacked]

While waiting to complete testing for your diagnosis, you can start to replenish the vitamins and minerals deficiencies caused by malabsorbtion due to autoimmune villi damage caused by Celiac Disease and the SAD standard American diet. My personal feeling is that if any test is positive it is just a matter of time until it gets worse. The official diagnosis is more so the insurance and physicians will take your complaints seriously. Loosely it takes around 10 years from symptoms to diagnosis. Wheat is sacrosanct in our culture. There are over 200 symptoms and syndromes that Celiac Disease and associated vitamin and mineral deficiencies can mimic and cause misdiagnoses. https://www.celiac.com/articles.html/what-are-the-symptoms-of-celiac-disease-r1090/page/12/#comment-22626

1 hour ago, MissMollyMarie said:

liver disease with a high number like that... diarrhea (yellow) for five months.  I also have nausea and fatigue.  

Are you getting enough Choline in your diet? Keeping in mind that we have been misinformed about eggs and meat and milk and fat and that today's food production methods have increased the omega 6 (inflammation) to omega 3 (healing) ratio from an ideal of less than 4:1 up to 20:1. Physicians have little education on nutrition. There are no accurate tests generally done for choline although a high homocysteine test results might indicate deficiency in choline, B6, folate and/or B12.  Eat more, or take supplements and you will in short order see the improvement. The FDA set the adequite daily intake at 450 mg/day. That means that 50% of the population will not get sick at this level. In food equivelance that is 4 large eggs or 10 cups of cooked brocolli a day. Or a 15 ounce lean steak.  Eat all three for 1500 mg. The safe upper limit is 3500 mg.

Gall Bladder, A Vital Organ That is Being Removed At Alarming Rates "Gall Bladder Syndrome is one of the most expensive, easily preventable conditions affecting Americans, causing a reported 3,000 deaths and over 800,000 hospitalizations annually. "

 Need More Choline?  "And while earlier research indicated that most Americans get plenty of this nutrient [chholine], a recent study from Iowa State found that only 10 percent or less of older children, men, women and pregnant women actually get enough."

Quote

Liver / Gallbladder   Symptoms include: intolerance to greasy foods; headaches after eating; light colored stool; foul smelling stool.

  Nutrients Involved: Choline, inositol, vitamin B6, folic acid, vitamin B12, magnesium, taurine, vitamin C

 

 

[MissMollyMarie]

4 hours ago, trents said:

If I were you, I'd push for an upper GI with biopsies taken of the duodenum and duodenum bulb (the two areas of the small bowel where celiac disease damages the villi that line the area). This would be to check for celiac disease but in the process he would also look at your esophagus and your stomach for ulcers and a biopsy should be done to check for H. Pylori, a gastric infection that causes most peptic ulcers.

Liver disease could cause light colored stools. You would need a CMP (Complete metabolic panel) to check for elevated liver enzymes. By the way, elevated liver enzymes are common with celiac disease and in fact, it was what led to my diagnosis of celiac disease.

Interesting...  I will definitely write these notes down for my doctor's appointment on Monday.  Than you again for taking the time to help me.  I truly appreciate it. 

[MissMollyMarie]

1 hour ago, Wheatwacked said:

While waiting to complete testing for your diagnosis, you can start to replenish the vitamins and minerals deficiencies caused by malabsorbtion due to autoimmune villi damage caused by Celiac Disease and the SAD standard American diet. My personal feeling is that if any test is positive it is just a matter of time until it gets worse. The official diagnosis is more so the insurance and physicians will take your complaints seriously. Loosely it takes around 10 years from symptoms to diagnosis. Wheat is sacrosanct in our culture. There are over 200 symptoms and syndromes that Celiac Disease and associated vitamin and mineral deficiencies can mimic and cause misdiagnoses. https://www.celiac.com/articles.html/what-are-the-symptoms-of-celiac-disease-r1090/page/12/#comment-22626

Are you getting enough Choline in your diet? Keeping in mind that we have been misinformed about eggs and meat and milk and fat and that today's food production methods have increased the omega 6 (inflammation) to omega 3 (healing) ratio from an ideal of less than 4:1 up to 20:1. Physicians have little education on nutrition. There are no accurate tests generally done for choline although a high homocysteine test results might indicate deficiency in choline, B6, folate and/or B12.  Eat more, or take supplements and you will in short order see the improvement. The FDA set the adequite daily intake at 450 mg/day. That means that 50% of the population will not get sick at this level. In food equivelance that is 4 large eggs or 10 cups of cooked brocolli a day. Or a 15 ounce lean steak.  Eat all three for 1500 mg. The safe upper limit is 3500 mg.

Gall Bladder, A Vital Organ That is Being Removed At Alarming Rates "Gall Bladder Syndrome is one of the most expensive, easily preventable conditions affecting Americans, causing a reported 3,000 deaths and over 800,000 hospitalizations annually. "

 Need More Choline?  "And while earlier research indicated that most Americans get plenty of this nutrient [chholine], a recent study from Iowa State found that only 10 percent or less of older children, men, women and pregnant women actually get enough."

 

Wow! Wow! Wow!  I am not sure if you didn't share this with me, that I would have ever learned about vitamins and nutrients that I need.  Thank you so very much for taking the time to write me!  I will do some research and get started!

[trents]

Molly, to answer an earlier question that I missed, your Gliadin IgA at 182.6 is quite high. No, that is not normal. Anything above 19.8 is not normal. You really do need to have an endoscopy with biopsy of the small bowel lining to check for celiac disease. It is the most likely culprit given the data you have supplied. There is the high Gliadin IGA and there are classic symptoms.

Also, unless you would have liver disease that is fairly advanced, I do not think it would cause the light colored stools. And if you had advanced liver disease you would be jaundiced. I didn't want you to fret unnecessarily over that.

[MissMollyMarie]

12 hours ago, trents said:

Molly, to answer an earlier question that I missed, your Gliadin IgA at 182.6 is quite high. No, that is not normal. Anything above 19.8 is not normal. You really do need to have an endoscopy with biopsy of the small bowel lining to check for celiac disease. It is the most likely culprit given the data you have supplied. There is the high Gliadin IGA and there are classic symptoms.

Also, unless you would have liver disease that is fairly advanced, I do not think it would cause the light colored stools. And if you had advanced liver disease you would be jaundiced. I didn't want you to fret unnecessarily over that.

I will absolutely ask for an endoscopy.  I am hoping they can do that at the same time as my colonoscopy.  Good times!  Lol!  Thank you again for your help. 🥰