Understanding labs

[TYH]

My daughter got an endoscopy and these were the results. I got them from the portal. The doctor said he wont be able to get back to me for over a week due to vacation. Can anyone help me interpret this? 

Esophagus Intraepithelial Eosinophils
Peak eosinophil count per hpf: 45
Eosinophil microabscess formation: negative
Superficial layering of eosinophils: positive
Extracellular eosinophilic : positive
Subepithelial fibrosis of lamina propria: positive
Basal  zone hyperplasia: positive
Surface epithelial alteration: positive
Dyskeratotic epithelial cells: negative

[TYH]

Diagnosis
A. Duodenum, biopsy:
- Duodenal mucosa with preserved villous architecture; negative for metaplasia, dysplasia, and
intraepithelial lymphocytes.

B. Duodenal bulb, biopsy:
- Duodenal mucosa with preserved villous architecture; negative for metaplasia, dysplasia, and
intraepithelial lymphocytes.

C. Antrum and body, biopsy:
- Gastric antral and oxyntic mucosa with mild chronic inflammation; negative for metaplasia and
dysplasia.
- H. pylori organisms are absent (Giemsa).

D. Distal esophagus, biopsy:
- Squamous epithelium with intraepithelial eosinophils (approximately 22 eosinophils in 1
high-power field); negative for fungal elements (Alcian blue/PAS).

E. Mid esophagus, biopsy:
- Squamous mucosa with intraepithelial eosinophils (approximately 45 eosinophils in 1 high-power
field).

F. Proximal esophagus, biopsy:
- Squamous epithelium with intraepithelial eosinophils (approximately 12 eosinophils in 1
 

 

Testing for celiac and suspected eoe

[TYH]

The eoe seems positive. How about the celiac?

[VGala]

Hi, 

Not 100% but it shows eosinophilic esophagitis and since villi are preserved, neg for celiac. Should f/u with Gi. Hope you feel better soon. 

[TYH]

thanks for your response.  How about the mild chronic inflammation does that say anything for celiac? 

The celiac ttg was higher than normal on the blood test

[TYH]

i have a follow up with the doctor but the next appointment was in two weeks

[VGala]

38 minutes ago, TYH said:

thanks for your response.  How about the mild chronic inflammation does that say anything for celiac? 

The celiac ttg was higher than normal on the blood test

Typically, loss of villi is diagnostic of celiac. Inflammation can occur from various other causes too… so not specific for celiac 

[TYH]

thank you!

[Russ H]

13 hours ago, TYH said:

thanks for your response.  How about the mild chronic inflammation does that say anything for celiac? 

The celiac ttg was higher than normal on the blood test

Regarding IgA tTG2 serum antibodies: a level of 10x upper standard range or greater is pretty unequivocal for coeliac disease. However other conditions can cause moderately raised levels, particularly inflammatory conditions of the bowel, liver and joints, e.g. Crohn's disease, rheumatoid arthritis.

[TYH]

IGA is non existent in the body that's why they did a ttg. Would the eosinophilic esophagitis raise the levels?