Just getting started...

[Guest 648]

Hi all.  Just getting started to see if the dreaded celiac disease has encroached into my world.  I been eating a lot of gluten products preceding labs tests.  I got a few of the results back.  What is your take on them?  That is, if you care to comment on them.  I am not seeking medical advice, just some thoughts from those who have experience.  Blood values not give just interpretation.

TOTAL IGA:  NORMAL
TTG, IGA:  NEGATIVE
TTG, IGG:  NEGATIVE
Endomysial Antibody IgA:  NEGATIVE
Deamidated gliadin peptidic (DGP) antibodies, IGA:  POSITIVE
Deamidated gliadin peptidic (DGP) antibodies, IGG:  POSITIVE

 

Thanks for reading and good luck to all.....

648

[RMJ]

It looks like you have two tests that indicate celiac disease. One does not need to have all of the tests positive in order to have it.

[Russ H]

Do you have the levels measured and standard ranges for those tests? I.e. are they borderline raised or very high?

In young children, anti-DGP antibodies come up before anti-tTG but don't know if this is true in adults.

[knitty kitty]

Yes, anti-DGP testing is valid in adults.

Antibodies against deamidated gliadin peptides identify adult coeliac disease patients negative for antibodies against endomysium and tissue transglutaminase

https://pubmed.ncbi.nlm.nih.gov/20456302/

"In this study of patients...IgA/IgG-DGP identified adult coeliac disease patients negative for antibodies against endomysium and tissue transglutaminase."

 

[Guest 648]

Thank you all for the valuable info.  Its been a little troublesome for me and my Dr because I also have Cutaneous and Systemic Lupus as well as Sjogrens Syndrome.  For instance, my 2 rash biopsies reports, one of which is a DIF, state clinically it looks like DH but cannot rule out lupus either.  But due to other symptoms etc.  I feel its DH.  I am never rash free.  I always get eczema and scle rashes but the one on my elbows is blistering and I never seen that before.   I guess my next stop will be the GI doc.  Not looking forward to being scoped.

Thank you again.  Your info is very helpful to me.

....648

The lab levels are:

- IgA -
YOUR VALUE:   STANDARD RANGE:    FLAG:
352 mg/dL           40 - 350 mg/dL               H
    
- TTGA -   
YOUR VALUE:   STANDARD RANGE:    FLAG:
 8 U/mL                  <15 U/mL
(NEGATIVE)

- TTGG -
YOUR VALUE:   STANDARD RANGE:    FLAG:
 <1 U/mL                <15 U/mL
(NEGATIVE)

- Endomysial Antibody IgA -
YOUR VALUE:   STANDARD RANGE:    FLAG:
 (NEGATIVE)     [no ranges given]

- Deamidated gliadin peptidic (DGP) antibodies, IGA -
YOUR VALUE:   STANDARD RANGE:    FLAG:
  168 U/mL            <15 U/mL                       H

- Deamidated gliadin peptidic (DGP) antibodies, IGG -
YOUR VALUE:   STANDARD RANGE:    FLAG:
  63.7 U/mL               <15 U/mL                   H

[Russ H]

That looks like a strong positive for anti-DGP antibodies. It is also possible to have antibodies against related enzymes tTG3 and tTG6 rather than the tTG2 that you were tested for. tTG3 is implicated in DH, and tTG6 in gluten induced neuropathy (GIN). Few centres test for these specific antibodies at the moment. It is also possible to have DH or GIN without showing gut damage.

[Guest 648]

17 hours ago, Russ H said:

That looks like a strong positive for anti-DGP antibodies. It is also possible to have antibodies against related enzymes tTG3 and tTG6 rather than the tTG2 that you were tested for. tTG3 is implicated in DH, and tTG6 in gluten induced neuropathy (GIN). Few centres test for these specific antibodies at the moment. It is also possible to have DH or GIN without showing gut damage.

Thank you Russ H  Thats very interesting.