Link between celiac and globulin or eosinophils

[unicornflakes]

Anyone here familiar or had an experience of celiac diagnosis relating to globulin / eosinophils level? It’s very challenging for me to be granted a celiac testing in my country, they only allow for a basic screening first. Is globulin of 43 and albumin of 42 normal? Is eosinophil 4.2 normal? Can any of this be an indicator of celiac?

[Wheatwacked]

Hello @unicornflakes,

there is a definate connection.  It seems like there is not much direct research, though. Celiac Disease causes malabsorption which over time causes malnutrition. Specifically insuffucient choline can cause liver enzyme imbalance.  Also low vitamin D is common in all autoimmune diseases, including celiac. Best results seem to be around 80 ng/ml (200 nmole/L). High homocysteine in blood can indicate difficient absorption of Choline, B6, B12 and or Folate.  Your globulin is either missing a decimal point or is super high. (The normal range of globulin is around 2.0-3.9 g/dL or 20-39 g/L.) Globulin and albumin are proteins found in the blood. Levels that are too high can indicate autoimmune disease, infections or cancers. The normal A/G ratio is 0.8-2.0. yours is 42/43 = 0.98. Normal.

Any other symptoms.  Celiac Disease has over 200 that, though not traditionally associated, can show improvement with a gluten free protocol.  What Are the Symptoms of Celiac Disease?

Association of Serum Albumin, Globulin, and Transferrin Levels in Children of Poorly Managed Celiac Disease  "Increased globulin level indicates that the body is under some malfunctioning. Since autoimmune disorders cause inflammatory reactions, the highest globulin peak (4.6 g/dl) was also observed in group D, which was DM1 with celiac disease. The normal range in healthy folks should be 2-3.5 g/dl. Since albumin and globulins play an essential role in immunity and inflammation processes, we speculate that an elevation in globulins could be a helpful marker for detecting silent/subclinical celiac disease."

Vitamin D and the Immune System

Surge of information on benefits of vitamin D

Choline

 

 

 

 

 

[trents]

The connection with celiac disease and eosinophils/globulin would be indirect and could be by many other conditions. So, the answer is "no". Celiac disease cannot be diagnosed with these other labs but they can be a clue that suggests the need for testing that is specific to celiac disease.

[unicornflakes]

1 hour ago, Wheatwacked said:

Hello @unicornflakes,

there is a definate connection.  It seems like there is not much direct research, though. Celiac Disease causes malabsorption which over time causes malnutrition. Specifically insuffucient choline can cause liver enzyme imbalance.  Also low vitamin D is common in all autoimmune diseases, including celiac. Best results seem to be around 80 ng/ml (200 nmole/L). High homocysteine in blood can indicate difficient absorption of Choline, B6, B12 and or Folate.  Your globulin is either missing a decimal point or is super high. (The normal range of globulin is around 2.0-3.9 g/dL or 20-39 g/L.) Globulin and albumin are proteins found in the blood. Levels that are too high can indicate autoimmune disease, infections or cancers. The normal A/G ratio is 0.8-2.0. yours is 42/43 = 0.98. Normal.

Any other symptoms.  Celiac Disease has over 200 that, though not traditionally associated, can show improvement with a gluten free protocol.  What Are the Symptoms of Celiac Disease?

Association of Serum Albumin, Globulin, and Transferrin Levels in Children of Poorly Managed Celiac Disease  "Increased globulin level indicates that the body is under some malfunctioning. Since autoimmune disorders cause inflammatory reactions, the highest globulin peak (4.6 g/dl) was also observed in group D, which was DM1 with celiac disease. The normal range in healthy folks should be 2-3.5 g/dl. Since albumin and globulins play an essential role in immunity and inflammation processes, we speculate that an elevation in globulins could be a helpful marker for detecting silent/subclinical celiac disease."

Vitamin D and the Immune System

Surge of information on benefits of vitamin D

Choline

 

 

 

 

 

Thanks, this is very helpful to me! My globulin was 43 g/L. I had my vitamin B12 tested and it was normal too. I’m having a really hard time convincing Doctors that I need the specific celiac test. Seems like they will point to everything else and rule out one by one before getting to the celiac test. 

[unicornflakes]

46 minutes ago, trents said:

The connection with celiac disease and eosinophils/globulin would be indirect and could be by many other conditions. So, the answer is "no". Celiac disease cannot be diagnosed with these other labs but they can be a clue that suggests the need for testing that is specific to celiac disease.

Understood, I really hope I can have the celiac test done eventually. Started with having altered bowel movements, frequent heart palpitations and unexplained infertility. I have tried going gluten free for a few days and feels much better.

[Wheatwacked]

1 minute ago, unicornflakes said:

I have tried going gluten free for a few days and feels much better.

This is the most important. You may have Non Celiac Gluten Sensitivity which is officially diagnosed by ruling out Celiac Disease. Some researchers believe that Celiac and NCGS are are different levels of the same disease. Bottom line is they both respond to the same treatment. Absolute avoidance of wheat, rye and barley products and cross contamination. Regardless of other test results if you continue eating gluten you will not get better. You may or may not have other things going on, but with the results of your trial period, as long as you persist in eating gluten it will skew any other tests. Best example I can think of is all of the people in the US needing gall bladder surgery, before finally starting gluten free.

17 minutes ago, unicornflakes said:

Seems like they will point to everything else and rule out one by one before getting to the celiac test. 

There is a lot of money invested in proving Celiac is not as ubiquitous as it is. Also the modern wheat has opiod effects and is addictive. Try telling a wheateater he is addicted to it and you will get the same over protective response as telling a friend he has a problem with alcohol. By the way, after 30 years of alcoholism my addiction to it went away the same week I started gluten free.  Unlike most recovering alcoholics who cannot touch the stuff without eliciting a binge, I can take a drink without even finishing the glass. When I started GFD I was drinking 500 ml of vodka a day, the next week, no craving.

[Wheatwacked]

Low vitamin D and choline are also found in infertility.

[unicornflakes]

7 minutes ago, Wheatwacked said:

By the way, after 30 years of alcoholism my addiction to it went away the same week I started gluten free.

Interesting! I’ve never come across this as one of the perks going gluten-free  

[unicornflakes]

10 minutes ago, Wheatwacked said:

You may have Non Celiac Gluten Sensitivity which is officially diagnosed by ruling out Celiac Disease.

I may or may not have celiac then, but based on this, a celiac test is still needed to check for either, is that correct? With various symptoms presence, I thought I didn’t need the formal diagnosis and could just go gluten-free. However I could not convince my siblings that they too, may have celiac. The diagnosis is really important to me considering my late father had heart failure and colon cancer. I somehow believe it could have been celiac all along.

[trents]

Please realize that if you decide to stick with the gluten free diet it will invalidate any form of testing for celiac disease.

I also wanted to say that 3rd party blood antibody testing for celiac disease is available through companies like Imaware for about $100 US.

Edited May 3, 2023 by trents

[trents]

There is no reliable test for NCGS (Non Celiac Gluten Sensitivity). Celiac disease must first be ruled out. They share many of the same symptoms but NCGS is 10x more common.

[unicornflakes]

15 minutes ago, Wheatwacked said:

Low vitamin D and choline are also found in infertility.

Will try take vit D and choline supplements after!

[unicornflakes]

4 minutes ago, trents said:

Please realize that if you decide to stick with the gluten free diet it will invalidate any form of testing for celiac disease.

I also wanted to say that 3rd party blood antibody testing for celiac disease is available through companies like Imaware for about $100 US.

Understood, I’m no longer on GFD and on gluten challenge (on my own plan, not advised by Dr yet) as i have set an appointment to meet a GI for the first time next week. Hopefully I get to convince him  to grant me the celiac test.

Meanwhile, I’m not sure if Imaware would reach Malaysia. And i wish the test isn’t as costly here  

[cristiana]

My globulin levels were 41, albumin 44, total serum protein 85 before I was diagnosed.

My consultant told me they see this from time to time in celiacs.  The levels are now normal.

[Russ H]

11 hours ago, unicornflakes said:

Anyone here familiar or had an experience of celiac diagnosis relating to globulin / eosinophils level? It’s very challenging for me to be granted a celiac testing in my country, they only allow for a basic screening first. Is globulin of 43 and albumin of 42 normal? Is eosinophil 4.2 normal? Can any of this be an indicator of celiac?

How do you mean basic screening? The basic test for coeliac disease is a blood test for IgA tTG2 antibodies. If you have chronic gastrointestinal symptoms, that should be reason enough for a test. Without units and the lab reference range it is not possible to evaluate the results you have supplied. I assume it is grams per litre, so it is high normal for globulin, normal for albumin. Assuming eosinophils is x109/L, then that is significantly raised.

[Russ H]

8 hours ago, unicornflakes said:

Interesting! I’ve never come across this as one of the perks going gluten-free  

It is quite common to experience neurological symptoms with coeliac disease, particularly anxiety and short term memory problems. I used to drink in the same way as it provides rapid relief from the symptom of anxiety.

[unicornflakes]

8 hours ago, cristiana said:

My globulin levels were 41, albumin 44, total serum protein 85 before I was diagnosed.

Same total protein but my globulins were slightly higher than albumin. Thanks for sharing! In that case I should just bring along my blood test results to see GI.

[unicornflakes]

2 hours ago, Russ H said:

How do you mean basic screening?

The clinic I went to did not have basic celiac test and they refused to provide me a referral to the hospital for a celiac test. They requested me to get the basic blood screening test done at the clinic and would only provide me with the referral after (guess they were trying to milk some money). Long story short, I got my results (all normal except globulin and eosinophils) but the Dr at the clinic still insisted that everything’s normal. She finally provided me with a referral anyway when I fought for it. Next week I will try to convince another Dr at the hospital for the celiac test while bringing this basic blood test results which I’m not certain would be helpful or not.

[unicornflakes]

2 hours ago, Russ H said:

I assume it is grams per litre, so it is high normal for globulin, normal for albumin. Assuming eosinophils is x109/L, then that is significantly raised.

Yes it is in grams per litre. I saw it was starred in the results (not falling in normal range); but the Dr was dismissive and saying it is normal as sometimes the reading would go slightly higher based on what you eat and not necessarily celiac. i had gluten the night before the blood test hence it might explain the elevated globulin levels. Not sure about oesinophils level though. It is very challenging to get acknowledged for suspecting celiac in this country.

[unicornflakes]

2 hours ago, Russ H said:

anxiety and short term memory problems

I see, both my sisters have this! I should not tell them this vodka tips though  I’ll spread the awareness and continue to convince them to go gluten-free.