Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

I Found A Great Article Regarding The Molecular Mechanisms Of Celiac Disease


JennyC

Recommended Posts

JennyC Enthusiast

While doing some online research I found a great article about the molecular pathogenesis of celiac disease. As a molecular biology fanatic, it really bothered me that I couldn't get a clear picture of the molecular steps to this disease. This article really helped. It goes into GREAT DETAIL about all components of the disease. (Although it must have been written before the work on zonulin was published.) If the scientific jargon gets to be too much, then click on figure 5 and it will give you a nice and to the point summary of the disease. :)

Open Original Shared Link


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



Nantzie Collaborator

Thanks for posting this. Lots of detail that I've never seen.

Nancy

corinne Apprentice

Great article. Thanks. I also found the genetic tree of the grains interesting. It's interesting that rice is a shorter genetic distance to wheat (not sure whether tree is linear or logarithmic) than maize yet it seems that more people react corn than rice. It would be interesting treeing gliadin.

larry mac Enthusiast

jc,

My thanks also. This is very informative (not that I understand all of it). Different presentation than I've seen previously, I like it very much.

best regards, lm

mm&j Apprentice
While doing some online research I found a great article about the molecular pathogenesis of celiac disease. As a molecular biology fanatic, it really bothered me that I couldn't get a clear picture of the molecular steps to this disease. This article really helped. It goes into GREAT DETAIL about all components of the disease. (Although it must have been written before the work on zonulin was published.) If the scientific jargon gets to be too much, then click on figure 5 and it will give you a nice and to the point summary of the disease. :)

Open Original Shared Link

Thanks also, I need to understand in detail also.

mm&j (Susie)

Archived

This topic is now archived and is closed to further replies.

  • Celiac.com Sponsor (A19):
  • Member Statistics

    • Total Members
      133,199
    • Most Online (within 30 mins)
      7,748

    Andrea Spencer
    Newest Member
    Andrea Spencer
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):
  • Forum Statistics

    • Total Topics
      121.6k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):
  • Upcoming Events

  • Posts

    • Scott Adams
      Celiac disease is the most likely cause, but here are articles about the other possible causes:    
    • xxnonamexx
      Please read: https://www.fda.gov/news-events/press-announcements/fda-takes-steps-improve-gluten-ingredient-disclosure-foods?fbclid=IwY2xjawPeXhJleHRuA2FlbQIxMABicmlkETFzaDc3NWRaYzlJOFJ4R0Fic3J0YwZhcHBfaWQQMjIyMDM5MTc4ODIwMDg5MgABHrwuSsw8Be7VNGOrKKWFVbrjmf59SGht05nIALwnjQ0DoGkDDK1doRBDzeeX_aem_GZcRcbhisMTyFUp3YMUU9Q
    • cristiana
      Hi @Atl222 As @trents points out, there could be many reasons for this biopsy result.  I am interested to know, is your gastroenterologist concerned?  Also, are your blood tests showing steady improvement over the years? I remember when I had my last biopsy, several years after diagnosis, mine came back with with raised lymphocytes but no villous damage, too! In my own case, my consultant wasn't remotely concerned - in fact, he said I might still get this result even if all I ever did was eat nothing but rice and water.   My coeliac blood tests were still steadily improving, albeit slowly, which was reassuring.
    • trents
      Welcome to the celiac.com community, @Atl222! Yes, your increased lymphocytes could be in response to oats or it could possibly be cross contamination from gluten that is getting into your diet from some unexpected source but not enough to damage the villi. And I'm certain that increased lymphocytes can be caused by other things besides celiac disease or gluten/oats exposure. See attachment. But you might try eliminating oats to start with and possibly dairy for a few months and then seek another endoscopy/biopsy to see if there was a reduction in lymphocyte counts. 
    • Scott Adams
      This is a solid, well-reasoned approach. You’re right that “koji” by itself doesn’t indicate gluten status, and the risk really does come down to which grain is used to culture it. The fact that you directly contacted Eden Foods and received a clear statement that their koji is made from rice only, with no wheat or barley, is meaningful due diligence—especially since Eden has a long-standing reputation for transparency. While the lack of gluten labeling can understandably give pause, manufacturer confirmation like this is often what people rely on for traditionally fermented products. As always, trusting your body after trying it is reasonable, but based on the information you gathered, your conclusion makes sense.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.