Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Has Anyone Heard Of The New Enzyme Being Developed?

metsfan11

Recommended Posts

metsfan11 Newbie
metsfan11
Posted

My mom told me about it the other day, and said that a lab in Maryland had a successful trial with an enzyme that enables celiacs to have gluten and be ok. I googled it and got this:

Open Original Shared Link

Open Original Shared Link

Sounds good to me! ;)

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Teacher1958 Apprentice
Teacher1958
Posted

If that ever happens, I will fly straight to New York City and eat out at Da Nico's. That would be sooooooooooooo awesome!!! Next, I would fly back and drive to Wooster, Ohio, where I would have a Coccia House Pizza. Then I would find somewhere that serves vegetable tempura. After that, I would go to the Olive Garden and have their eggplant parmesan. I'd find a Mexican place and scarf down some chili rellenos. I would also need to track down some spaghetti, a chimichanga, and the Floridian French toast at First Watch, then to Bob Evans for some blueberry pancakes followed by anything vegetarian at Cafe Tandoor in Westlake, Ohio. I would have to have several types of scones to celebrate my Irish heritage as well. This could go on forever theoretically, so I will stop now. Suffice it to say that eating out used to be my favorite activity in the whole world!

holdthegluten Rising Star
holdthegluten
Posted

I guess I will at this to my prayer list...........please say it works!

holdthegluten Rising Star
holdthegluten
Posted

I just noticed that the article is almost a year old...... hopefully they are still trying to approve it

  • 2 weeks later...
namklak Newbie
namklak
Posted

It appears that clinical trials are next. Who will pay for a clinical trial of a cheap food mold? This will include the cost of repeated EGDs. Clinical trials include a control group who will be taking a placebo and eating gluten - care to volunteer? I'm not feeling real positive about this will ever happening...

SunnyDyRain Enthusiast
SunnyDyRain
Posted
It appears that clinical trials are next. Who will pay for a clinical trial of a cheap food mold? This will include the cost of repeated EGDs. Clinical trials include a control group who will be taking a placebo and eating gluten - care to volunteer? I'm not feeling real positive about this will ever happening...

I agree, I have been interested in doing trials before, and It always came down to...what If i'm in the placebo group?

If it does come through, I would prolly use this sparingly. Prolly pop one if I'm eating out, or a If I want some thing with a small amount of gluten.

I probally would not have myself a big bowl of pasta.

chrissy Collaborator
chrissy
Posted

there are a couple of things hoping to treat celiac disease in the works right now. besides the enzyme, there is the zonulin antagonist that dr. fasano is working on-----it is already in the second phase of human trials. i have read somewhere that a combo of the enzyme and the antagonist might work pretty well. our ped gi tells me that there are hopes of developing a celiac vaccine. of course, this wouldn't help my girls any since they already have it, but their kids might not have to worry about celiac.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Murph Newbie
Murph
Posted

I've heard of 2 such efforts (AT1001 & a Stanford effort) but I don't believe either will work. celiac disease is not like lactose intolerance where the symptoms are temporary and relatively minor compared to celiac disease.

I think it just doesn't work that way - it's not just a missing enzyme.

I've had far too many of the symptoms on these 2 pages to ever consider having gluten again. (Especially the 2nd list)

https://www.celiac.com/st_prod.html?p_prodi...-15104373588.a8

https://www.celiac.com/st_prod.html?p_prodi...-15104373588.a8

debmidge Rising Star
debmidge
Posted

I don't think Zonulin is an enzyme ... I think they have a website to read how it works. It's not like lastase (Lactaid) - I believe it works on the cell level.

It's already in human trials.

chrissy Collaborator
chrissy
Posted

the AT1001 is a zonulin antagonist. zonulin is the chemical in our bodies that controls the "gates" in the small intestine that let food proteins out where they don't belong. in celiacs these gates get stuck open. AT1001 controls the amount of zonulin so that the gates stay shut when a person eats gluten. this is by no means intended to be a cure, but it sure could make things easier for celiacs.

Derek Borckmann Newbie
Derek Borckmann
Posted

I looked on thier website and found some results of the testing. Seems real positive but time will tell.

Open Original Shared Link

  • 4 weeks later...
maryjk Newbie
maryjk
Posted
our ped gi tells me that there are hopes of developing a celiac vaccine. of course, this wouldn't help my girls any since they already have it, but their kids might not have to worry about celiac.

I was just at the GIG conference and heard Dr. Fasano speak.

According to him, the vaccine would be for EVERYONE. Even if you already have Celiac, it would be for you.

Also, the time frame that he gave was

2-3 years for detoxified grains

5-8 years for Anti-Zonulin Pill

15-20 years for the Vaccine

He spent quite a while explaining how the pill would work. It is not like lactaid or whatever it is called. It blocks the production of Zonulin. Zonulin is what opens the doors in our intestines and allows the gluten in. Keep the doors locked and the gluten would not enter. (This is a very general explanation. The doctor spoke for an hour, this being the topic for about a third of it

Guest Doll
Guest Doll
Posted
I've heard of 2 such efforts (AT1001 & a Stanford effort) but I don't believe either will work. celiac disease is not like lactose intolerance where the symptoms are temporary and relatively minor compared to celiac disease.

I think it just doesn't work that way - it's not just a missing enzyme.

I've had far too many of the symptoms on these 2 pages to ever consider having gluten again. (Especially the 2nd list)

https://www.celiac.com/st_prod.html?p_prodi...-15104373588.a8

https://www.celiac.com/st_prod.html?p_prodi...-15104373588.a8

AT-1001 actually CLOSES the leaky gut. I am *very* excited about it. It could be applied to the treatment of *all* autoimmune diseases.

I cannot wait. It actually fixes one of the root causes of the pathology of autoimmune disease, including Celiac.

debmidge Rising Star
debmidge
Posted

It sounds very exciting and more info can be found at albatheraputics.com

  • 2 weeks later...
mfl Newbie
mfl
Posted
My mom told me about it the other day, and said that a lab in Maryland had a successful trial with an enzyme that enables celiacs to have gluten and be ok. I googled it and got this:

Open Original Shared Link

Open Original Shared Link

Sounds good to me! ;)

radgirl Enthusiast
radgirl
Posted

This would be an absolute God send. We can gather as a big group and fly all over the world and eat like kings. :D

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,140
    • Most Online (within 30 mins)
      7,748
    KP009
    Newest Member
    KP009
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • trents
      Headaches / Migraines and Hypoglycaemia

      By trents · Posted

      My migraines generally have their onset during the early morning hours as well. Presently, I am under siege with them, having headaches all but two days so far this month. I have looked at all the things reported to be common triggers (foods, sleep patterns, weather patterns, stress, etc.). Every time I think I start to see a pattern it proves not to pan out in the long run. I'm not sure it's any one thing but may, instead, be a combination of things that coalesce at certain times. It's very frustrating. The medication (sumatriptan or "Imatrix") is effective and is the only thing that will quell the pain. NSAIDs, Tylenol, even hydrocodone doesn't touch it. But they only give you 9 does of sumatriptan a month. And it doesn't help that medical science doesn't really know what causes migraines. They know some things about it but the root cause is still a mystery.
    • Scott Adams
      Tamale ingredients

      By Scott Adams · Posted

      These are labeled gluten-free: https://www.amazon.com/Corn-Husks-Tamales-Authentic-Flavorful/dp/B01MDSHUTM/
    • Wheatwacked
      GI DX celiac despite neg serology and no biopsy

      By Wheatwacked · Posted

      Just a gluten free diet is not enough.  Now you have to identify and replenish your malnutrition.  Celiac disease is co-morbid with malabsorption syndrome.  Low vitamin D, Low Thiamine caused Gastointeston Beriberi, low choline, low iodine are common the general population, and in newly diagnosed Celiacs in the western culture its is more likely.  It takes time to heal and you need to focus on vitamins and minerals.  Gluten free foods are not fortified like regular processed foods.  
    • Sarah Grace
      Headaches / Migraines and Hypoglycaemia

      By Sarah Grace · Posted

      Dear Kitty Since March I have been following your recommendations regarding vitamins to assist with various issues that I have been experiencing.  To recap, I am aged 68 and was late diagnosed with Celiac about 12 years ago.  I had been experiencing terrible early morning headaches which I had self diagnosed as hypoglycaemia.  I also mentioned that I had issues with insomnia, vertigo and brain fog.   It's now one year since I started on the Benfotiamine 600 mg/day.  I am still experiencing the hypoglycaemia and it's not really possible to say for sure whether the Benfotiamine is helpful.  In March this year, I added B-Complex Thiamine Hydrochloride and Magnesium L-Threonate on a daily basis, and I am now confident to report that the insomnia and vertigo and brain fog have all improved!!  So, very many thanks for your very helpful advice. I am now less confident that the early morning headaches are caused by hypoglycaemia, as even foods with a zero a GI rating (cheese, nuts, etc) can cause really server headaches, which sometimes require migraine medication in order to get rid off.  If you are able to suggest any other treatment I would definitely give it a try, as these headaches are a terrible burden.  Doctors in the UK have very limited knowledge concerning dietary issues, and I do not know how to get reliable advice from them. Best regards,
    • knitty kitty
      High DGP-A with normal IGA

      By knitty kitty · Posted

      @rei.b,  I understand how frustrating starting a new way of eating can be.  I tried all sorts of gluten-free processed foods and just kept feeling worse.  My health didn't improve until I started the low histamine AIP diet.  It makes a big difference.   Gluten fits into opioid receptors in our bodies.  So, removing gluten can cause withdrawal symptoms and reveals the underlying discomfort.  SIBO can cause digestive symptoms.  SIBO can prevent vitamins from being absorbed by the intestines.  Thiamine insufficiency causes Gastrointestinal Beriberi (bloating, abdominal pain, nausea, diarrhea or constipation).  Thiamine is the B vitamin that runs out first because it can only be stored for two weeks.  We need more thiamine when we're sick or under emotional stress.  Gastric Beriberi is under recognised by doctors.  An Erythrocyte Transketolace Activity test is more accurate than a blood test for thiamine deficiency, but the best way to see if you're low in thiamine is to take it and look for health improvement.  Don't take Thiamine Mononitrate because the body can't utilize it well.  Try Benfotiamine.  Thiamine is water soluble, nontoxic and safe even at high doses.  I thought it was crazy, too, but simple vitamins and minerals are important.  The eight B vitamins work together, so a B Complex, Benfotiamine,  magnesium and Vitamin D really helped get my body to start healing, along with the AIP diet.  Once you heal, you add foods back in, so the AIP diet is worth doing for a few months. I do hope you'll consider the AIP diet and Benfotiamine.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.