Celiac Or Not?

[MrsGabbyP]

My 5 year old son has severe food allergies...anaphylaxis to Tree Nuts, Peanuts, Eggs an shellfish. He has never had a problem with wheat. He had a time where over 2 weeks( in September) had severe cramping, diarrhea, and throwing up. Upon keeping track of his diet we thought the source was wheat. Kept him on wheat and had some initial tests...

IgA 1 Negative

IgG 22 High

tTG (IgA) 1 Negative

tTG (IgG) 1 Negative

Endomysial Antibody (IgA) Negative

Immunoglobulin A, Qn, Serum Negative

Went gluten free right after testing....symptoms resolved.

Saw GI doc who ran additional testing... (back on gluten at this point)No more symptoms

Occult Blood feces Negative

H. Pylori IgG Negative

Full Blood Screen....all normal except

ALT & AST (Liver) high

RBC Low

EOS (eosinophil) high

C-Reactive Protein high

GI guy doubted Celiac ....went to another GI who ordered:

Prometheus Celiac Genetics... (+) HLA DQ2 (+)14 AGA IgG (ELISA) all else in normal range

Smooth Muscle Autoantibodies negative

Antinuclear antibodies negative

ceruloplasmin negative

LKM-1 IgGAutoabs negative

Hepatitis Panel Negative

Did retesting on Blood panel with high liver numbers....all normal

Son had two new incidents with throwing up after meals...both meals included wheat....came on suddenly and is fine afterward....

Any ideas? Anyone familiar with EE?

Going to go back to GI....what should I ask for...I know he might suggest an endoscopy...leery to do that to my 5 year old.

[happygirl]

The high eosinophil count could be indicative of an eosinophilic disorder (not limited to just eos. esophagitis, but all parts of the digestive track-stomach, small intestine, large intestine).

A good resource for eos. disorders is www.apfed.org

There is the possibility that he has an eos. disorder, and wheat is a trigger (even if he doesn't test positive via IgE allergy testing).

Considering that this could be a multitude of problems, esp with the multiple allergies/symptoms, I think it would be helpful for an endoscopy----to rule in/out various disorders.

The CRP is often a marker for autoimmune problems.