What Does This Mean?

[Lux]

I have just been reviewing my blood tests, having been given a referral for a biopsy by my GP, and am a little confused over the results...it states the following:

Anti Endomysium (IgA): not detected.

Tissue Transglutaminase (IgA): 60 units (<16) H

IgA: 3.00 g/l (0.9 - 4.0)

My doc has stated that the Tissue Transglutaminase antibodies are exorbitantly high, and therefore indicative of Celiac. However, I was wondering at the results for Anti Endomysium ("not detected")...can you test positive for one, and not the other, and still have Celiac? Why would I get one result that is so apparently off the charts, whilst the other indicator for C is completely absent? How does this work??

[Gemini]

I have just been reviewing my blood tests, having been given a referral for a biopsy by my GP, and am a little confused over the results...it states the following:

Anti Endomysium (IgA): not detected.

Tissue Transglutaminase (IgA): 60 units (<16) H

IgA: 3.00 g/l (0.9 - 4.0)

My doc has stated that the Tissue Transglutaminase antibodies are exorbitantly high, and therefore indicative of Celiac. However, I was wondering at the results for Anti Endomysium ("not detected")...can you test positive for one, and not the other, and still have Celiac? Why would I get one result that is so apparently off the charts, whilst the other indicator for C is completely absent? How does this work??

A high Ttg is indicative of other autoimmune diseases also. Hashimoto's thyroid will cause elevated Ttg so it could be that you have another problem, undetected, that is causing these numbers.

[ravenwoodglass]

I have just been reviewing my blood tests, having been given a referral for a biopsy by my GP, and am a little confused over the results...it states the following:

Anti Endomysium (IgA): not detected.

Tissue Transglutaminase (IgA): 60 units (<16) H

IgA: 3.00 g/l (0.9 - 4.0)

My doc has stated that the Tissue Transglutaminase antibodies are exorbitantly high, and therefore indicative of Celiac. However, I was wondering at the results for Anti Endomysium ("not detected")...can you test positive for one, and not the other, and still have Celiac? Why would I get one result that is so apparently off the charts, whilst the other indicator for C is completely absent? How does this work??

The TTG is one of the most reliable tests for celiac. I do not know why the IGA is not detected but I would go with the thought that it is most likely celiac. If you choose to biopsy make sure you are on a full gluten diet until the endo, or you could do a strict try of the diet for a couple of months to see how you react to it. If you don't improve on the diet then it may be another issue but I would firmly rule out celiac through dietary exclusion before I went through other tests trying to find something else. For one thing other things they find may actually be caused by celiac and resolve on the diet. The autoimmune reaction caused by celiac doesn't just effect the gut and many of us have other issues that were a direct effect of celiac but not recognized as such until the diet makes the issues go away on their own.