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Please Help With Blood Test Results

Amyleigh0007

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Amyleigh0007 Enthusiast
Amyleigh0007
Posted

My son was diagnosed with Celiac a few months ago (both bloodwork and biopsy positive). I have have bowel issues all of my life and the symptoms seemed to have gotten much worse after the birth of my daughter 9 months ago. I thought I had found my answer and was fully expecting a positive dx. I had bloodwork done and everything came back negative. My TTG antibody was <3 (<5 negative, 5-8 equivocal, >8 positve reference range) and my IGA Serum is 179 (81-463 reference range). Can anyone tell me more about my results? I am not sure if I should drop it or pursue more tests. Thank you for your help!

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lizard00 Enthusiast
lizard00
Posted

Welcome to the forum!!

Have you tried the gluten free diet? The number of people on here with negative bloodwork but either a diagnosis or positive results is pretty high. My bloodwork was negative, but I have Celiac.

It really is up to you at this point if you want to pursue it. If you try the diet, you skew your chances of an accurate result. But if you decide to pursue it, don't quit eating gluten for any length of time.

Are those two tests the only ones they did?

nora-n Rookie
nora-n
Posted

The blood tests, especially ttg and EMA are really calibrated to be positive only in th most severe cases and are negative in 20% even then.

nora

Rachel--24 Collaborator
Rachel--24
Posted
My son was diagnosed with Celiac a few months ago (both bloodwork and biopsy positive). I have have bowel issues all of my life and the symptoms seemed to have gotten much worse after the birth of my daughter 9 months ago. I thought I had found my answer and was fully expecting a positive dx. I had bloodwork done and everything came back negative. My TTG antibody was <3 (<5 negative, 5-8 equivocal, >8 positve reference range) and my IGA Serum is 179 (81-463 reference range). Can anyone tell me more about my results? I am not sure if I should drop it or pursue more tests. Thank you for your help!

I would pursue more testing. You were only tested for one antibody (tTG). Also, some people will have a positive biopsy despite negative bloodwork. I would request the Celiac panel.

The IgA Serum is to make sure that you're not IgA deficient.

As previously mentioned you could try the diet to find out if gluten is your problem....just be sure that you do not wish to pursue testing before you start the diet.

Genetic testing could also be useful as your son may have gotten his Celiac gene from his father.

Amyleigh0007 Enthusiast
Amyleigh0007
Posted
  • Author

After my son was dx I stocked the kitchen with gluten-free food and that's what I was eating too, it was just easier for all of us to eat the same things. I did have some gluten each day, but for the most part I was gluten-free. I am afraid my gluten-free diet for those 10 weeks resulted in negative tests. Is that possible? I was not aware that cutting gluten before testing could result in negative tests until I started really reading posts from this website and others. By then it was too late. My family dr has referred me to a GI. I will talk to him about the pros and cons of more testing. Thank you for your help! I truly appreciate it.

Rachel--24 Collaborator
Rachel--24
Posted
I am afraid my gluten-free diet for those 10 weeks resulted in negative tests. Is that possible?

Yes...you would have to be eating gluten in order for the tests to be accurate. If you take gluten out of your diet antibody levels go down. 10 weeks gluten-free can definately result in a false negative.

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    • trents
      Blood tests low iGA 4 years later digestive issues

      By trents · Posted

      Welcome to the forum, @Mmoc! Please include the reference ranges for the IGA and the TTG tests in your next post if you have access to them. We cannot comment much otherwise as different labs use different reference ranges for these tests and also different units of measurement. There are no universal standards as of yet so the raw test numbers are not always helpful. Having said that, if your IGA (what we usually call "total IGA") is low, the TTG-IGA score will be skewed and cannot be trusted. Other kinds of tests for celiac disease would need to be run, particularly those in the IGG family of tests. Perhaps this will be helpful:  
    • Mmoc
      Blood tests low iGA 4 years later digestive issues

      By Mmoc · Posted

      Hi there any advice welcomed. I have had 4 years of symptoms ranging from immune related anaphylactic symptom sudden onset food allergy to peppers/paprika/chilli/capsicum family derivatives. all these allergies fizzled out and following a food challenge test in hospital I reintroduced them a few months ago. Since then my digestive system is a mess. i have since noticed that 4 years ago when testing for iga allergies my iga level was .62 and my ttg was less than .1 (due to symptoms I was probably eating very plainly at that time). should I insist on being retested for celiac? I’ve since read two indicators for celiac include: sensitive to spicy foods when in flare up tooth enamel weakness and symmetrical discolouration patches on teeth which I have had since childhood on my two front teeth     thanks
    • trents
      Headaches / Migraines and Hypoglycaemia

      By trents · Posted

      This article does not address migraines at all.  Yes, red wine and sulfites are often mentioned in connection with migraine triggers. With me, any kind of alcoholic beverage in very modest amounts will reliably produce a migraine. Nitrous oxide generators, which are vaso dialators, also will give me migraines reliably. So, I think most of my migraines are tied to fluctuations vascular tension and blood flow to the brain. That's why the sumatriptan works so well. It is a vaso constrictor. 
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      Headaches / Migraines and Hypoglycaemia

      By knitty kitty · Posted

      Excessive dietary tyrosine can cause problems.  Everything in moderation.   Sulfites can also trigger migraines. Sulfites are found in fermented, pickled and aged foods, like cheese.  Sulfites cause a high histamine release.  High histamine levels are found in migraine.  Following a low histamine diet like the low histamine Autoimmune Protocol diet, a Paleo diet, helps immensely.    Sulfites and other migraine trigger foods can cause changes in the gut microbiome.  These bad bacteria can increase the incidence of migraines, increasing histamine and inflammation leading to increased gut permeability (leaky gut), SIBO, and higher systemic inflammation.   A Ketogenic diet can reduce the incidence of migraine.  A Paleo diet like the AIP diet, that restricts carbohydrates (like from starchy vegetables) becomes a ketogenic diet.  This diet also changes the microbiome, eliminating the bad bacteria and SIBO that cause an increase in histamine, inflammation and migraine.  Fewer bad bacteria reduces inflammation, lowers migraine frequency, and improves leaky gut. Since I started following the low histamine ketogenic AIP paleo diet, I rarely get migraine.  Yes, I do eat carbs occasionally now, rice or potato, but still no migraines.  Feed your body right, feed your intestinal bacteria right, you'll feel better.  Good intestinal bacteria actually make your mental health better, too.  I had to decide to change my diet drastically in order to feel better all the time, not just to satisfy my taste buds.  I chose to eat so I would feel better all the time.  I do like dark chocolate (a migraine trigger), but now I can indulge occasionally without a migraine after.   Microbiota alterations are related to migraine food triggers and inflammatory markers in chronic migraine patients with medication overuse headache https://pmc.ncbi.nlm.nih.gov/articles/PMC11546420/  
    • trents
      Headaches / Migraines and Hypoglycaemia

      By trents · Posted

      Then we would need to cut out all meat and fish as they are richer sources of tyrosine than nuts and cheese. Something else about certain tyrosine rich foods must be the actual culprit. 
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