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Genes -- Are You Cd Positive?

Professor

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Professor Rookie
Professor
Posted

I was just reading the HLA types that are responsible for celiac disease, and then dug mine (printout of my genes) out of my file drawer (I have them because I was tested for a bone marrow transplant). They listed several HLA types on the site I was reading, and say that almost everyone with celiac disease has one of those in the first group, but the few that don't almost always have this other one. Be darned if I don't have both -- one in the first group, and also the one that is the "back-up!" :o Unbelievable, huh? Guess I was just bound to get celiac disease.

So I was wondering how many also have the gene that causes celiac disease, or if you were tested?

Patty

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KaitiUSA Enthusiast
KaitiUSA
Posted

Yep I have the celiac disease gene. That's one thing they tested me for in the blood test I had done

celiac3270 Collaborator
celiac3270
Posted

Me, too

mommida Enthusiast
mommida
Posted

My daughter has 2 genes for Celiac. DQ2 and Dq8.

red345 Apprentice
red345
Posted

If you're referring to the DQ2 and DQ8, mine were negative, though I am a Type 1 Diabetic. That was also the case for my family member, whose blood and biopsies at one time read positive for Celiac. And that is exactly why I've never bought into this, at least in her case.

Professor Rookie
Professor
Posted
  • Author
If you're referring to the DQ2 and DQ8 . . .

Well, I guess that must be an abbreviated description -- sorry I don't know it as such. The full typing assays, and my own molecular diagnostics reports list them fully:

"The majority of celiac disease patients carry the DRB1*0301- DQA1*0501- DQB1*0201 haplotype (the DR3, DQ2 haplotype) or are DRB1*11/12-DQA1*0505- DQB1*0301/ DRB1*07- DQA1*0201- DQB1*0202 heterozygotes (carry the DR5-DQ7/DR7-DQ2 haplotypes). Almost all the celiac patients who are DQA1*05 and DB1*02 negative bear the DRB1*04, DQA1*0301, DQB1*0302 haplotype (i.e., DR4-DQ8 )."

So, unfortunately I can only answer your question with another question: are we referring to the same thing? I think so. :unsure: But thanks for replying.

Patty

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Maggie1956 Rookie
Maggie1956
Posted

:huh: Umm...well my blood test came back positive. So did my biopsy. <_< Is that what you mean? I'm really quite uneducated, when it comes to all the medical terms.

Cheers :)

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MySuicidalTurtle Enthusiast
MySuicidalTurtle
Posted

I don't know but I think I would since my Mother and brother both have Celiacs.

red345 Apprentice
red345
Posted

Excellent question, professor. I'll take another look into this. I know that there has been some confusion along the way in her case. Her medical reports detail testing for the DQ2 and DQ8, both of which were negative. I can say for certain that these tests also are defined in my medical history. I did research this at one time and the lab titles seemed to go along with what I was reading, but I will try to go back and take another look here at some point.

I must compliment you for the type of investigation you are attempting here. Great work.

burdee Enthusiast
burdee
Posted

My Enterolab test results (back in 7/04) indicated that I "have a copy of one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQ3, subtype 8 (HLA-DQ8). This genotype also can predispose to microscopic colitis and other autoimmune syndromes".

BURDEE

KaitiUSA Enthusiast
KaitiUSA
Posted

I have the HLA-DQ2 gene. Does anybody know if this gene comes from both parents?

gf4life Enthusiast
gf4life
Posted

It can come from either parent or from both if you have two copies or one of each.

My daughter and I both have one copy of DQ2. My boys don't have either but are still gluten intolerant. They both have DQ3, subtype 7. DQ3, subtype 8 is the one referred to as DQ8. I am still wondering if they have missed the fact that other subtypes of DQ3 can cause problems with gluten. I have all of the children on the gluten-free diet, since they all responded so well to the diet. Almost all of their health problems went away and their growth has been amazing.

God bless,

Mariann

KaitiUSA Enthusiast
KaitiUSA
Posted

Thanks:) If I have 2 copies of the gene that would mean it came from both parents correct?

Also, when I was tested for the gene would they have told me if there was more than one copy of the gene in the results?

We are trying to figure out which side it came frome it seems both sides of the family think it is the other side that has the gene and they aren't being to easy about getting tested <_<

Thank you all for your help :D

gf4life Enthusiast
gf4life
Posted
Also, when I was tested for the gene would they have told me if there was more than one copy of the gene in the results?

They would not necessarily tell you if you had more than one copy. They would only be required to tell you if you were positive for the gene or not. It would be a good idea for your parents to be tested, regardless of if there are two copies of the gene, or if they have symptoms. But I do understand about them not being easy about getting tested. My husband won't be tested, and my father is convinced that it isn't an issue. I have 6 siblings and only one has tried to be tested, and her doctor is clueless as to what tests to order. My sister decided to let it go for now, since she doesn't plan on following the gluten-free diet anyhow!

God bless,

Mariann

KaitiUSA Enthusiast
KaitiUSA
Posted

gf4life-Thank you so much. That info definately helps out so much. My parents have both been tested. Digestive problems run in the family on both sides and we suspect possibly some cousins ,grandma, and others that may have celiac. They aren't necessarily convinced either and it's hard because we can only tell them so much and give them so much info. I guess when their symptoms get bad enough they will be tested. Again thanks and God bless! :D

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      @rei.b,  I understand how frustrating starting a new way of eating can be.  I tried all sorts of gluten-free processed foods and just kept feeling worse.  My health didn't improve until I started the low histamine AIP diet.  It makes a big difference.   Gluten fits into opioid receptors in our bodies.  So, removing gluten can cause withdrawal symptoms and reveals the underlying discomfort.  SIBO can cause digestive symptoms.  SIBO can prevent vitamins from being absorbed by the intestines.  Thiamine insufficiency causes Gastrointestinal Beriberi (bloating, abdominal pain, nausea, diarrhea or constipation).  Thiamine is the B vitamin that runs out first because it can only be stored for two weeks.  We need more thiamine when we're sick or under emotional stress.  Gastric Beriberi is under recognised by doctors.  An Erythrocyte Transketolace Activity test is more accurate than a blood test for thiamine deficiency, but the best way to see if you're low in thiamine is to take it and look for health improvement.  Don't take Thiamine Mononitrate because the body can't utilize it well.  Try Benfotiamine.  Thiamine is water soluble, nontoxic and safe even at high doses.  I thought it was crazy, too, but simple vitamins and minerals are important.  The eight B vitamins work together, so a B Complex, Benfotiamine,  magnesium and Vitamin D really helped get my body to start healing, along with the AIP diet.  Once you heal, you add foods back in, so the AIP diet is worth doing for a few months. I do hope you'll consider the AIP diet and Benfotiamine.
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    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      Okay well the info about TTG-A actually makes a lot of sense and I wish the PA had explained that to me. But yes, I would assume I would have intestinal damage from eating a lot of gluten for 32 years while having all these symptoms. As far as avoiding gluten foods - I was definitely not doing that. Bread, pasta, quesadillas (with flour tortillas) and crackers are my 4 favorite foods and I ate at least one of those things multiple times a day e.g. breakfast with eggs and toast, a cheese quesadilla for lunch, and pasta for dinner, and crackers and cheese as a before bed snack. I'm not even kidding.  I'm not really big on sugar, so I don't really do sweets. I don't have any of those conditions.  I am not sure if I have the genes or not. When the geneticist did my genetic testing for EDS this year, I didn't think to ask for him to request the celiac genes so they didn't test for them, unfortunately.  I guess another expectation I had is  that if gluten was the issue, the gluten-free diet would make me feel better, and I'm 3 months in and that hasn't been the case. I am being very careful and reading every label because I didn't want to screw this up and have to do gluten-free for longer than necessary if I end up not having celiac. I'm literally checking everything, even tea and anything else prepacked like caramel dip. Honestly its making me anxious 😅
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      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
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      I was tested for celiac at the same time, so I wasn't taking naltrexone yet. I say that, because I don't. The endoscopy showed some mild inflammation but was inconclusive as to celiac disease. They took several biopsies and that's all that was shown. I was not given a Marsh score.
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