Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Genetic Testing For Celiac - Questions


marie06

Recommended Posts

marie06 Rookie

Hello, I have been gluten-free since 6/5 and 99% Casein free as well since then. I had an endoscopy done on 6/5 to see why I had been nauseous for almost 2 years and I asked the GI doc to do a biposy. He did 1, and said it was negative for Celiac (but note, only one sample was taken). 6 weeks later I went to be tested for food allergies and the doc did a Celiac blood test which also came back negative. HOWEVER, I have definitely seen a huge health improvement from going gluten-free and so I plan to stick with it. Now, my questions lie in the genetic testing that can be done for Celiac:

1) how accurate are these tests? I know that they can biopsy spots w/o damaged villi, and you could still have Celiac....and I know blood tests are not always accurate (esp when gluten-free for awhile). So what is the accuracy of the genetic testing?

2) is there a 'better' genetic test lab than another?

3) I am assuming a genetic marker will show up regardless of how long you have been gluten-free?

4) any other thoughts to share with regard to the above?

The reason I am concerned is mostly for my daughters sake. She is not showing any Celiac symptoms, but if she has a genetic marker for this, I think it would be good to know (OR if she DOESNT have the marker, I can stop worrying if she might get it). I call her my little "Carb-ovore" because she loves bread and pasta, would live on that if I let her. But she has no health issues that we know of and is fine on the growth chart, (actually 90%ile).

It would also be somewhat helpful for me to know if I am CELIAC or just Gluten Intolerant. Thanks in advance!


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



ShayFL Enthusiast

I used Enterolab and Kimball for genetic. This explains it well:

https://www.celiac.com/articles/21567/1/Ten...ting/Page1.html

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      132,201
    • Most Online (within 30 mins)
      7,748

    Judy Wysocki
    Newest Member
    Judy Wysocki
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Posts

    • Xravith
      I'm very confused... My blood test came out negative, I checked all antibodies. I suppose my Total IgA levels are normal (132 mg/dl), so the test should be reliable. Still, I'm not relieved as I can't tolerate even a single biscuit. I need to talk to my doctor about whether a duodenal biopsy is necessary. But it is really possible to have intestinal damage despite having a seronegative results? I have really strong symptoms, and I don't want to keep skipping university lectures or being bedridden at home.
    • Scott Adams
      They may want to also eliminate other possible causes for your symptoms/issues and are doing additional tests.  Here is info about blood tests for celiac disease--if positive an endoscopy where biopsies of your intestinal villi are taken to confirm is the typical follow up.    
    • Scott Adams
      In the Europe the new protocol for making a celiac disease diagnosis in children is if their tTg-IgA (tissue transglutaminase IgA) levels are 10 times or above the positive level for celiac disease--and you are above that level. According to the latest research, if the blood test results are at certain high levels that range between 5-10 times the reference range for a positive celiac disease diagnosis, it may not be necessary to confirm the results using an endoscopy/biopsy: Blood Test Alone Can Diagnose Celiac Disease in Most Children and Adults TGA-IgA at or Above Five Times Normal Limit in Kids Indicates Celiac Disease in Nearly All Cases No More Biopsies to Diagnose Celiac Disease in Children! May I ask why you've had so many past tTg-IgA tests done, and many of them seem to have been done 3 times during short time intervals?    
    • trents
      @JettaGirl, "Coeliac" is the British spelling of "celiac". Same disease. 
    • JettaGirl
      This may sound ridiculous but is this supposed to say Celiacs? I looked up Coeliacs because you never know, there’s a lot of diseases related to a disease that they come up with similar names for. It’s probably meant to say Celiacs but I just wanted to confirm.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.