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- RMJ replied to Kirita's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms2Help with genetic testing
HLA-DQ2 is NOT a continuum 2.01 to 2.99, but I don’t understand HLA genetics well enough to explain it further. It is not just one gene that is either this or that. -
- trents replied to Kirita's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms2Help with genetic testing
Okay, I'm taking a guess here. We are used to hearing in layman terms that having either the HLA-DQ2 or the HLA-DQ8 gene, either heterozygous or homozygous, presents the possibility of developing active celiac disease. So, I'm guessing that the HLA-DQ2 gene is actually a range of variants (2.01-2.99) with HLA-DQ 2.5 being in the centerpiece of the range... -
- Kirita posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms2Help with genetic testing
I received the results that my child has the genes for celiac disease (she is still undergoing testing and it has been complicated). Can someone explain if this is homozygous HLA DQ 2.5 or not? The interpretation just says permissive for celiac disease. Thank you! DQ Alpha 1 05:01, 5 DQ Beta 1 02:01, 02:01 DQ serologic... -
- Zuma888 replied to Zuma888's topic in Related Issues & Disorders9Burning sensation when I wake up
I am taking thiamine hydrochloride. It's been over a week, and the burning seems to be gone. I am also taking a lower dose B complex with iron. Thank you so much for your help! -
- trents replied to Zuma888's topic in Related Issues & Disorders9
Burning sensation when I wake up
No. It's over the counter. Readily available on Amazon. Good bio availability but shelf-life is not as good as thiamine mononitrate which is the most common form found in over the counter vitamin products.
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HLA-DQ2 is NOT a continuum 2.01 to 2.99, but I don’t understand HLA genetics well enough to explain it further. It is not just one gene that is either this or that. -
Okay, I'm taking a guess here. We are used to hearing in layman terms that having either the HLA-DQ2 or the HLA-DQ8 gene, either heterozygous or homozygous, presents the possibility of developing active celiac disease. So, I'm guessing that the HLA-DQ2 gene is actually a range of variants (2.01-2.99) with HLA-DQ 2.5 being in the centerpiece of the range. I'm also guessing that "permissive" is equivalent to "possessing the possibility" to develop active celiac disease and does not address the issue of hetero vs. homozygus per se. But the fact that 2.01,2.01 is a couplet may indicated homozygousity? All wild guesses.
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I received the results that my child has the genes for celiac disease (she is still undergoing testing and it has been complicated). Can someone explain if this is homozygous HLA DQ 2.5 or not? The interpretation just says permissive for celiac disease. Thank you! DQ Alpha 1 05:01, 5 DQ Beta 1 02:01, 02:01 DQ serologic equivalent 2,2
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I am taking thiamine hydrochloride. It's been over a week, and the burning seems to be gone. I am also taking a lower dose B complex with iron. Thank you so much for your help!
-
No. It's over the counter. Readily available on Amazon. Good bio availability but shelf-life is not as good as thiamine mononitrate which is the most common form found in over the counter vitamin products.
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