Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

I Need Your Assistance To Understand My Results

Rockgurl

Recommended Posts

Rockgurl Rookie
Rockgurl
Posted

I got my results from Enterolab today and they are positive. However, I do not understand the whole gene DQ thing. Here are my results:

HLA-DQB1 Molecular analysis, Allele 1: 0302

HLA-DQB1 Molecular analysis, Allele 2: 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,7)

What does that make me? Am I DQ1? DQ3? I don't understand how to interpret them. Can you help?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Lisa Mentor
Lisa
Posted
I got my results from Enterolab today and they are positive. However, I do not understand the whole gene DQ thing. Here are my results:

HLA-DQB1 Molecular analysis, Allele 1: 0302

HLA-DQB1 Molecular analysis, Allele 2: 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,7)

What does that make me? Am I DQ1? DQ3? I don't understand how to interpret them. Can you help?

Here is good, understandable information on gene testing (it can be very confusing):

Open Original Shared Link

Amyleigh0007 Enthusiast
Amyleigh0007
Posted

Is that all the information they sent you? I ordered the gene test today but I thought they would send an explanation along with the results. How long did it take to get the test and then get your results?

Rockgurl Rookie
Rockgurl
Posted
  • Author
Here is good, understandable information on gene testing (it can be very confusing):

Open Original Shared Link

Thanks for that. I have read it but am still none the wiser. Can anyone explain to me what I am?

Rockgurl Rookie
Rockgurl
Posted
  • Author
Is that all the information they sent you? I ordered the gene test today but I thought they would send an explanation along with the results. How long did it take to get the test and then get your results?

It took 2 weeks and 2 days. They sent me a detailed explnation but I still don't understand the gene/subtyping thing. This is what they gave me as an explanation:

Interpretation Of HLA-DQ Testing: HLA-DQB1 gene analysis reveals that you have one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HLA-DQB1*0302. Each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. You also have a non-celiac gene predisposing to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having one celiac gene and one gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of a gluten sensitive gene. Having two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

I just want to know what DQ type I am.

Amyleigh0007 Enthusiast
Amyleigh0007
Posted

So if I am reading your results correctly (practice for when I get my daughter and my results) you have one gluten sensitivity gene and one Celiac gene? And, because you have these two genes you are more likely to develop Celiac? Do you think you have Celiac?

Rockgurl Rookie
Rockgurl
Posted
  • Author
So if I am reading your results correctly (practice for when I get my daughter and my results) you have one gluten sensitivity gene and one Celiac gene? And, because you have these two genes you are more likely to develop Celiac? Do you think you have Celiac?

I think so but I don't know. I'm having my Endoscopy on Monday but I have been wheat free (although not gluten-free) for about a year. I've been eating wheat for the past few weeks and I feel toxic!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Amyleigh0007 Enthusiast
Amyleigh0007
Posted

Yeah, that's why I'm doing the gene test for myself. I feel like it's just another part of the puzzle. I refuse to go back on gluten (I've been gluten free now for a year) so I can have an endoscopy. I wish the gene tests weren't so hard to read. Good luck on Monday!

gfb1 Rookie
gfb1
Posted
Yeah, that's why I'm doing the gene test for myself. I feel like it's just another part of the puzzle. I refuse to go back on gluten (I've been gluten free now for a year) so I can have an endoscopy. I wish the gene tests weren't so hard to read. Good luck on Monday!

imho, 'puzzle' is the correct word.

buried on p2 of the u.chicago celiac disease center publication:

In fact, up to one third of the U.S. population has the genes for celiac disease, but it is thought that only 1-4% of them will actually develop the disease at some point in their lifetimes.

it certainly puzzles me.

ravenwoodglass Mentor
ravenwoodglass
Posted
I got my results from Enterolab today and they are positive. However, I do not understand the whole gene DQ thing. Here are my results:

HLA-DQB1 Molecular analysis, Allele 1: 0302

HLA-DQB1 Molecular analysis, Allele 2: 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,7)

What does that make me? Am I DQ1? DQ3? I don't understand how to interpret them. Can you help?

You are a DQ8, one of the recognized celiac related genes and DQ7 the gluten sensitive one.

The US has finally started to recognize that there are more celiac related genes than used to be thought. For a long time if you were not DQ8 or DQ2 you would be told that you were not celiac if you live in the US. This is not the case in other countries where the total number of celiac related genes is more like 9.

It is confusing but the bottom line IMHO is that whether you are 'celiac' or intolerant the need to be gluten free is the same.

Rockgurl Rookie
Rockgurl
Posted
  • Author
You are a DQ8, one of the recognized celiac related genes and DQ7 the gluten sensitive one.

The US has finally started to recognize that there are more celiac related genes than used to be thought. For a long time if you were not DQ8 or DQ2 you would be told that you were not celiac if you live in the US. This is not the case in other countries where the total number of celiac related genes is more like 9.

It is confusing but the bottom line IMHO is that whether you are 'celiac' or intolerant the need to be gluten free is the same.

Thank you very much. I understand now. I appreciate your help. :)

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,705
    • Most Online (within 30 mins)
      7,748
    Lyana Chahine
    Newest Member
    Lyana Chahine
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • deanna1ynne
      Inconclusive results

      By deanna1ynne · Posted

      She has been dairy free for six years, so she’d already been dairy free for two years at her last testing and was dairy free for the entire gluten challenge this year as well (that had positive results). However, now that we’re doing another biopsy in six weeks, we decided to do everything we can to try to “see” the effects, so we decided this past week to add back in dairy temporarily for breakfast (milk and cereal combo like you said).
    • Gigi2025
      How Come Gluten Didnt Bother Me In Italy

      By Gigi2025 · Posted

      Hi Christiana, Many thanks for your response.  Interestingly, I too cannot eat wheat in France without feeling effects (much less than in the US, but won't indulge nonetheless).  I also understand children are screened for celiac in Italy prior to starting their education. Wise idea as it seems my grandson has the beginning symptoms (several celiacs in his dad's family), but parents continue to think he's just being difficult.  Argh.  There's a test I took that diagnosed gluten sensitivity in 2014 via Entero Labs, and am planning on having done again.  Truth be told, I'm hoping it's the bromine/additives/preservatives as I miss breads and pastas terribly when home here in the states!  Be well and here's to our guts healing ❤️
    • Wends
      Inconclusive results

      By Wends · Posted

      Lol that’s so true! Hope you get clarity, it’s tough when there’s doubt. There’s so much known about celiac disease with all the scientific research that’s been done so far yet practically and clinically there’s also so much unknown, still. Out of curiosity what’s her dairy consumption like? Even compared to early years to now? Has that changed? Calcium is dependent in the mechanism of antigen presenting cells in the gut. High calcium foods with gluten grains can initiate inflammation greater.  This is why breakfast cereals and milk combo long term can be a ticking time bomb for genetically susceptible celiacs (not a scientific statement by any means but my current personal opinion based on reasoning at present). Milk and wheat are the top culprits for food sensitivity. Especially in childhood. There are also patient cases of antibodies normalising in celiac children who had milk protein intolerance/ delayed type allergy. Some asymptomatic. There were a couple of cases of suspected celiacs that turned out to have milk protein intolerance that normalised antibodies on a gluten containing diet. Then there were others that only normalised antibodies once gluten and milk was eliminated. Milk kept the antibodies positive. Celiac disease is complicated to say the least.
    • deanna1ynne
      Inconclusive results

      By deanna1ynne · Posted

      And thank you for your encouragement. I am glad that her body is doing a good job fighting it. I also just want clarity for her moving forwards. She was only 6 for the last round of testing and she's 10 now, so I'm also hoping that makes a difference. It was weird during her last round of testing though, because right before her biopsy, we'd upped her gluten intake by giving her biscuits made from straight up vital wheat gluten, and her labs actually normalized slightly (lower ttg and her ema went negative). Bodies just do weird things sometimes! lol
    • deanna1ynne
      Inconclusive results

      By deanna1ynne · Posted

      The first negative biopsy in 2021 just said "no pathological change" for all the samples, and the second one in 2022 said "Duodenal mucosa with mild reactive change (focal foveolar metaplasia) and preserved villous architecture." So I think Marsh score 0 in both cases, though it's not actually written in the pathology reports. I'm really hoping to get a clear positive result this time, just for her sake.  
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.