Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

I Need Your Assistance To Understand My Results

Rockgurl

Recommended Posts

Rockgurl Rookie
Rockgurl
Posted

I got my results from Enterolab today and they are positive. However, I do not understand the whole gene DQ thing. Here are my results:

HLA-DQB1 Molecular analysis, Allele 1: 0302

HLA-DQB1 Molecular analysis, Allele 2: 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,7)

What does that make me? Am I DQ1? DQ3? I don't understand how to interpret them. Can you help?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Lisa Mentor
Lisa
Posted
I got my results from Enterolab today and they are positive. However, I do not understand the whole gene DQ thing. Here are my results:

HLA-DQB1 Molecular analysis, Allele 1: 0302

HLA-DQB1 Molecular analysis, Allele 2: 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,7)

What does that make me? Am I DQ1? DQ3? I don't understand how to interpret them. Can you help?

Here is good, understandable information on gene testing (it can be very confusing):

Open Original Shared Link

Amyleigh0007 Enthusiast
Amyleigh0007
Posted

Is that all the information they sent you? I ordered the gene test today but I thought they would send an explanation along with the results. How long did it take to get the test and then get your results?

Rockgurl Rookie
Rockgurl
Posted
  • Author
Here is good, understandable information on gene testing (it can be very confusing):

Open Original Shared Link

Thanks for that. I have read it but am still none the wiser. Can anyone explain to me what I am?

Rockgurl Rookie
Rockgurl
Posted
  • Author
Is that all the information they sent you? I ordered the gene test today but I thought they would send an explanation along with the results. How long did it take to get the test and then get your results?

It took 2 weeks and 2 days. They sent me a detailed explnation but I still don't understand the gene/subtyping thing. This is what they gave me as an explanation:

Interpretation Of HLA-DQ Testing: HLA-DQB1 gene analysis reveals that you have one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HLA-DQB1*0302. Each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. You also have a non-celiac gene predisposing to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having one celiac gene and one gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of a gluten sensitive gene. Having two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

I just want to know what DQ type I am.

Amyleigh0007 Enthusiast
Amyleigh0007
Posted

So if I am reading your results correctly (practice for when I get my daughter and my results) you have one gluten sensitivity gene and one Celiac gene? And, because you have these two genes you are more likely to develop Celiac? Do you think you have Celiac?

Rockgurl Rookie
Rockgurl
Posted
  • Author
So if I am reading your results correctly (practice for when I get my daughter and my results) you have one gluten sensitivity gene and one Celiac gene? And, because you have these two genes you are more likely to develop Celiac? Do you think you have Celiac?

I think so but I don't know. I'm having my Endoscopy on Monday but I have been wheat free (although not gluten-free) for about a year. I've been eating wheat for the past few weeks and I feel toxic!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Amyleigh0007 Enthusiast
Amyleigh0007
Posted

Yeah, that's why I'm doing the gene test for myself. I feel like it's just another part of the puzzle. I refuse to go back on gluten (I've been gluten free now for a year) so I can have an endoscopy. I wish the gene tests weren't so hard to read. Good luck on Monday!

gfb1 Rookie
gfb1
Posted
Yeah, that's why I'm doing the gene test for myself. I feel like it's just another part of the puzzle. I refuse to go back on gluten (I've been gluten free now for a year) so I can have an endoscopy. I wish the gene tests weren't so hard to read. Good luck on Monday!

imho, 'puzzle' is the correct word.

buried on p2 of the u.chicago celiac disease center publication:

In fact, up to one third of the U.S. population has the genes for celiac disease, but it is thought that only 1-4% of them will actually develop the disease at some point in their lifetimes.

it certainly puzzles me.

ravenwoodglass Mentor
ravenwoodglass
Posted
I got my results from Enterolab today and they are positive. However, I do not understand the whole gene DQ thing. Here are my results:

HLA-DQB1 Molecular analysis, Allele 1: 0302

HLA-DQB1 Molecular analysis, Allele 2: 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,7)

What does that make me? Am I DQ1? DQ3? I don't understand how to interpret them. Can you help?

You are a DQ8, one of the recognized celiac related genes and DQ7 the gluten sensitive one.

The US has finally started to recognize that there are more celiac related genes than used to be thought. For a long time if you were not DQ8 or DQ2 you would be told that you were not celiac if you live in the US. This is not the case in other countries where the total number of celiac related genes is more like 9.

It is confusing but the bottom line IMHO is that whether you are 'celiac' or intolerant the need to be gluten free is the same.

Rockgurl Rookie
Rockgurl
Posted
  • Author
You are a DQ8, one of the recognized celiac related genes and DQ7 the gluten sensitive one.

The US has finally started to recognize that there are more celiac related genes than used to be thought. For a long time if you were not DQ8 or DQ2 you would be told that you were not celiac if you live in the US. This is not the case in other countries where the total number of celiac related genes is more like 9.

It is confusing but the bottom line IMHO is that whether you are 'celiac' or intolerant the need to be gluten free is the same.

Thank you very much. I understand now. I appreciate your help. :)

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. Wheatwacked
      - Wheatwacked replied to MauraBue's topic in Gluten-Free Foods, Products, Shopping & Medications
      2

      Have Tru Joy Sweets Choco Chews been discontinued??

      M&M Peanuts. About the same calories and sugar while M&M Peanuts have fiber, potassium, iron and protein that Tootsie Rolls ("We are currently producing more than 50 million Tootsie Rolls each day.") don't. Click the links to compare nutritional values. Both are made with sugar, not high fructose corn syrup. I use them as a gluten free substitute...
    2. Theresa2407
      - Theresa2407 replied to chrish42's topic in Doctors
      6

      Doctors and Celiac.com

      I see it everyday on my feeds. They go out and buy gluten-free processed products and wonder why they can't heal their guts. I don't think they take it as a serious immune disease. They pick up things off the internet which is so far out in left field. Some days I would just like to scream. So much better when we had support groups and being able to teach...
    3. Scott Adams
      - Scott Adams replied to MauraBue's topic in Gluten-Free Foods, Products, Shopping & Medications
      2

      Have Tru Joy Sweets Choco Chews been discontinued??

      Some of the Cocomels are gluten and dairy-free: https://cocomels.com/collections/shop-page
    4. Scott Adams
      - Scott Adams replied to chrish42's topic in Doctors
      6

      Doctors and Celiac.com

      Thank you for the kind words! I keep thinking that things in the medical community are improving, but a shocking number of people still post here who have already discovered gluten is their issue, and their doctors ordered a blood test and/or endoscopy for celiac disease, yet never mentioned that the protocol for such screening requires them to be eating...
    5. trents
      - trents replied to catnapt's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      how much gluten do I need to eat before blood tests?

      The rate of damage to the villous lining of the SB and the corresponding loss of nutrient absorbing efficiency varies tremendously from celiac to celiac. Yes, probably is dose dependent if, by dose dependent you mean the amount of exposure to gluten. But damage rates and level of sensitivity also seem to depend on the genetic profile. Those with both genes...
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      133,261
    • Most Online (within 30 mins)
      7,748
    Joanne Ham
    Newest Member
    Joanne Ham
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.6k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • Wheatwacked
      Have Tru Joy Sweets Choco Chews been discontinued??

      By Wheatwacked · Posted

      M&M Peanuts. About the same calories and sugar while M&M Peanuts have fiber, potassium, iron and protein that Tootsie Rolls ("We are currently producing more than 50 million Tootsie Rolls each day.") don't. Click the links to compare nutritional values.  Both are made with sugar, not high fructose corn syrup.  I use them as a gluten free substitute for a peanut butter sandwich.  Try her on grass fed, pasture fed milk. While I get heartburn at night from commercial dairy milk, I do not from 'grassmilk'.     
    • Theresa2407
      Doctors and Celiac.com

      By Theresa2407 · Posted

      I see it everyday on my feeds.  They go out and buy gluten-free processed products and wonder why they can't heal their guts.  I don't think they take it as a serious immune disease. They pick up things off the internet which is so far out in left field.  Some days I would just like to scream.  So much better when we had support groups and being able to teach them properly. I just had an EMA blood test because I haven't had one since my Doctor moved away.  Got test results today, doctor ordered a D3 vitamin test.  Now you know what  type of doctors we have.  Now I will have to pay for this test because she just tested my D3 end of December, and still have no idea about my EMA.    
    • Scott Adams
      Have Tru Joy Sweets Choco Chews been discontinued??

      By Scott Adams · Posted

      Some of the Cocomels are gluten and dairy-free: https://cocomels.com/collections/shop-page
    • Scott Adams
      Doctors and Celiac.com

      By Scott Adams · Posted

      Thank you for the kind words! I keep thinking that things in the medical community are improving, but a shocking number of people still post here who have already discovered gluten is their issue, and their doctors ordered a blood test and/or endoscopy for celiac disease, yet never mentioned that the protocol for such screening requires them to be eating gluten daily for weeks beforehand. Many have already gone gluten-free during their pre-screening period, thus their test results end up false negative, leaving them confused and sometimes untreated. It is sad that so few doctors attended your workshops, but it doesn't surprise me. It seems like the protocols for any type of screening should just pop up on their computer screens whenever any type of medical test is ordered, not just for celiac disease--such basic technological solutions could actually educate those in the medical community over time.
    • trents
      how much gluten do I need to eat before blood tests?

      By trents · Posted

      The rate of damage to the villous lining of the SB and the corresponding loss of nutrient absorbing efficiency varies tremendously from celiac to celiac. Yes, probably is dose dependent if, by dose dependent you mean the amount of exposure to gluten. But damage rates and level of sensitivity also seem to depend on the genetic profile. Those with both genes HLA-DQ2 and HLA-DQ8 seem to be more sensitive to minor amounts of gluten exposure than those with just one of those genes and those with only DQ2 seem to be more sensitive than those with only DQ8. But there are probably many factors that influence the damage rate to the villi as well as intensity of reaction to exposure. There is still a lot we don't know. One of the gray areas is in regard to those who are "silent" celiacs, i.e. those who seem to be asymptomatic or whose symptoms are so minor that they don't garner attention. When they get a small exposure (such as happens in cross contamination) and have no symptoms does that equate to no inflammation? We don't necessarily know. The "sensitive" celiac knows without a doubt, however, when they get exposure from cross contamination and the helps them know better what food products to avoid.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.